Multiple physical cross-linked hydrogel and preparation method thereof

A physical cross-linking and hydrogel technology, which is applied in the preparation of hydrogel and the field of hydrogel, can solve the problems of poor mechanical properties, irreparable, easy to break, etc., and achieve strong self-recovery ability, low raw material cost, and low deformation strong recovery effect

Inactive Publication Date: 2019-01-11
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the defects that the hydrogels in the prior art generally have poor mechanical properties, are easy to break, and cannot be repaired once broken, the first purpose of the present invention is to provide a hydrogel that passes through multiple hydrogen bonds between organic compounds. The hydrogel with high strength and superstretch is constructed by multiple physical crosslinks such as hydrophobic bonding and metal coordination. The hydrogel not only has high strength and high elongation, but also has shape memory function. It greatly improves the practical application value of hydrogel

Method used

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  • Multiple physical cross-linked hydrogel and preparation method thereof
  • Multiple physical cross-linked hydrogel and preparation method thereof
  • Multiple physical cross-linked hydrogel and preparation method thereof

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Effect test

Embodiment 1

[0043] 4-{6-[3-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido]hexylcarbamoyloxy}butyl acrylate monomer (UPy-HCBA )Synthesis:

[0044] 0.07 mol of 2-amino-4-hydroxy-6-methylpyrimidine was added to 0.56 mol of hexyl diisocyanate solution, and reacted at 60° C. for 20 hours under the protection of nitrogen. After the reaction is stopped, a large amount of n-hexane is added for washing, and dried under vacuum at 50°C. Weigh 0.01 mol of the dried sample and dissolve it in 80 ml of chloroform, then add 0.012 mol of 4-hydroxybutyl acrylate, drop 2 drops of stannous octoate, and react at 60°C for 20 hours under the protection of nitrogen. After the reaction was stopped, a large amount of acetone was added for washing, and dried under vacuum at 50°C. 1 HNMR chart such as figure 2 As shown, figure 2 It shows that we successfully synthesized UPy-HCBA monomer. The synthetic route of UPy-HCBA monomer is as follows:

[0045]

Embodiment 2

[0047] Preparation of hydrogel:

[0048] (1) Add 0.18g of NaCl to 6mL of pure water to obtain a 0.5M sodium chloride solution.

[0049] (2) Add 0.42g of SDS to the above solution, stir at 35°C until it is clear, add UPy-HCBA monomer and stir to a uniformly dispersed emulsion, and then filter with a 220μm filter to obtain a clear and transparent solution. The DLS curve of the solution is as image 3 . image 3 It shows that after adding UPy-HCBA monomer, the particle size of SDS micelles is about 5nm.

[0050] (3) Add 1.27g AAm and 185μL AAc to the above solution, stir until it is clear and transparent, then add 0.04gAPS and 40μL TEMED, stir for a few minutes, leave it at room temperature overnight, and let it naturally form a biphysical crosslinked hydrogel (DPC-gel). Cut the gel into a dumbbell shape (5cm in width and 2cm in thickness), and then use 0.06mol / L of FeCl 3 Soaked in the solution for 4h, and finally the gel is dialyzed in pure water for 2 days to obtain a multi-physica...

Embodiment 3

[0052] Macro compression and tensile test:

[0053] Make cylindrical and thin strip hydrogels in different molds, and perform macroscopic compression and tensile experiments on the hydrogels, such as Figure 4 . Macroscopic compression test: Use two small glass plates to compress the cylindrical gel with a length of 3 cm to 1 cm and loosen it quickly. The gel can quickly return to its original shape. Macroscopic stretching experiment: knot the thin strip of hydrogel, and then slowly pull it to a certain length by hand.

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Abstract

The invention discloses multiple physical cross-linked hydrogel and a preparation method thereof. The preparation method of the hydrogel comprises the following steps: coating 4-{6-[3-(6-methyl-4-oxo-1,4-dihydropyrimidine-2-yl) carbamido] hexyl carbamyloxy}butyl acrylate (UPy-HCBA) in sodium dodecyl sulfonate (SDS) micelles, adding hydrophilic acrylamide monomer (AAm) and acrylic acid (AAc) outside the micelles, performing emulsion polymerization and physical crosslinking so as to prepare gel with excellent tensile property but low strength; and performing Fe<3+> coordination crosslinking on the gel, thereby obtaining the high-strength super-tensile hydrogel. The multiple physical cross-linked hydrogel is simple in preparation method, wide in raw material source and low in price, and has potential application value in the field of functional polymers.

Description

Technical field [0001] The invention relates to a hydrogel, in particular to a hydrogel with high strength and super-stretch through multiple physical crosslinks, and also relates to a preparation method of the hydrogel, which belongs to the field of functional polymer materials. Background technique [0002] The colloidal particles or polymers in the sol or solution are connected to each other under certain conditions to form a spatial network structure, and the structural voids are filled with liquid as a dispersion medium (it can also be a gas in a dry gel, and a dry gel is also called Aerogel), such a special dispersion system is called gel. According to the type of solvent, it can be divided into hydrogel and organic gel. In recent years, hydrogel gel has gradually developed into a class of intelligent / functional nanomaterials with broad application prospects. Due to its unique structure, hydrogels have many advantages, such as high water absorption, which can be used as h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08F220/56C08F220/34C08F220/06C08F2/26
CPCC08F2/26C08F220/56C08J3/075C08J3/243C08J2333/26C08F220/34C08F220/06
Inventor 孙晓毅王丛森李娟
Owner CENT SOUTH UNIV
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