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A kind of preparation method of starch-based porous microsphere

A technology of microspheres and starch, which is applied in the field of preparation of starch-based porous microspheres, can solve the problems of low porosity of starch-based microspheres, achieve the effects of increased binding force, increased porosity, and increased crosslinking degree

Active Publication Date: 2021-08-06
山东聊城华阳医药辅料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention is: aiming at the disadvantage of low porosity of traditional starch-based microspheres, a preparation method of starch-based porous microspheres is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Mix the surfactant and the solvent at a mass ratio of 1:15, stir and mix for 50 minutes at a temperature of 55°C and a rotational speed of 400r / min to obtain No. 1 mixed solution, and mix sodium carbonate and water at a mass ratio of 2: 7. Mix, and add polyvinylpyrrolidone with 0.4 times the mass of sodium carbonate to the mixture of sodium carbonate and water, and stir and mix for 80 minutes at a temperature of 65°C and a rotation speed of 400r / min to obtain No. 2 mixed solution. No. mixed solution and No. 2 mixed solution were mixed at a volume ratio of 7:3, and after ultrasonic dispersion at a frequency of 55kHz for 60 minutes, an emulsion was obtained. The emulsion and calcium chloride solution were mixed at a volume ratio of 1:3, and the Under the conditions of 55°C and 400r / min, stir and mix for 80 minutes, filter to obtain microsphere blanks, wash the microsphere blanks with water 10 times, and dry them at 80°C for 2 hours to obtain microspheres ; Mix the microsp...

example 2

[0026] Mix the surfactant and the solvent at a mass ratio of 1:15, stir and mix for 50 minutes at a temperature of 55°C and a rotational speed of 400r / min to obtain No. 1 mixed solution, and mix sodium carbonate and water at a mass ratio of 2: 7. Mix, and add polyvinylpyrrolidone with 0.4 times the mass of sodium carbonate to the mixture of sodium carbonate and water, and stir and mix for 80 minutes at a temperature of 65°C and a rotation speed of 400r / min to obtain No. 2 mixed solution. No. mixed solution and No. 2 mixed solution were mixed at a volume ratio of 7:3, and after ultrasonic dispersion at a frequency of 55kHz for 60 minutes, an emulsion was obtained. The emulsion and calcium chloride solution were mixed at a volume ratio of 1:3, and the Under the conditions of 55°C and 400r / min, stir and mix for 80 minutes, filter to obtain microsphere blanks, wash the microsphere blanks with water 10 times, and dry them at 80°C for 2 hours to obtain microspheres ;Mix the mixed st...

example 3

[0028]Mix the surfactant and the solvent at a mass ratio of 1:15, stir and mix for 50 minutes at a temperature of 55°C and a rotational speed of 400r / min to obtain No. 1 mixed solution, and mix sodium carbonate and water at a mass ratio of 2: 7. Mix, and add polyvinylpyrrolidone with 0.4 times the mass of sodium carbonate to the mixture of sodium carbonate and water, and stir and mix for 80 minutes at a temperature of 65°C and a rotation speed of 400r / min to obtain No. 2 mixed solution. No. mixed solution and No. 2 mixed solution were mixed at a volume ratio of 7:3, and after ultrasonic dispersion at a frequency of 55kHz for 60 minutes, an emulsion was obtained. The emulsion and calcium chloride solution were mixed at a volume ratio of 1:3, and the Under the conditions of 55°C and 400r / min, stir and mix for 80 minutes, filter to obtain microsphere blanks, wash the microsphere blanks with water 10 times, and dry them at 80°C for 2 hours to obtain microspheres ; Mix the microsph...

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Abstract

The invention discloses a preparation method of starch-based porous microspheres, belonging to the technical field of natural polymer materials. Mix the starch-based porous microsphere blank with water at a mass ratio of 1:10 to 1:15, and add amylase and starch that are 0.02 to 0.05 times the mass of the starch-based porous microsphere to the mixture of the starch-based porous microsphere blank and water 0.01 to 0.002 times the mass of lipase-based porous microspheres, stirred and mixed, filtered to obtain pretreated starch-based porous microspheres, pretreated starch-based porous microspheres and hydrochloric acid with a mass fraction of 10-18% by mass ratio 1 : 5 to 1: 6, stirred and mixed, filtered to obtain a filter cake, washed with deionized water for 5 to 8 times, and vacuum dried for 2 to 3 hours at a temperature of 80°C to obtain a starch-based porous microspheres. The starch-based porous microsphere prepared by the technical scheme of the invention has the characteristics of high porosity, and has broad prospects in the development of natural polymer material technology.

Description

technical field [0001] The invention discloses a preparation method of starch-based porous microspheres, belonging to the technical field of natural polymer materials. Background technique [0002] Starch is a naturally renewable, inexpensive and sustainable polysaccharide, which is considered as an alternative material for industrial polymers. In recent years, it has been discovered that starch-based microspheres prepared from starch have many advantages and uses. For example, starch microspheres have the advantages of biocompatibility, biodegradability, non-toxicity, stable storage, wide source of raw materials, and low price. , has been used as a drug carrier for targeted preparations in the fields of nasal drug delivery system, arterial embolization technology, radiotherapy, and immunoassay; starch microspheres can also be used as adsorbents and embedding agents to absorb or embed drugs. In addition to other substances, such as flavors, fragrances, enzymes and spores; c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J9/40C08J9/38C08J9/26C08L3/02C08L3/04C08L5/08C08L1/28C08L91/00
CPCC08J9/26C08J9/38C08J9/40C08J2201/0444C08J2303/04C08J2401/28C08J2403/04C08J2405/08C08J2491/00
Inventor 刘茂龙刘侠宋宇星
Owner 山东聊城华阳医药辅料有限公司