Cerebrospinal fluid leakage occlusion

A technology of cerebrospinal fluid leakage and solution, applied in the fields of application, medical science, peptide/protein composition, etc., can solve problems such as painful neuritis

Inactive Publication Date: 2019-01-11
3 D MATRIX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Epidural blood patches can be used for blockage, but they can cause complic...

Method used

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  • Cerebrospinal fluid leakage occlusion
  • Cerebrospinal fluid leakage occlusion
  • Cerebrospinal fluid leakage occlusion

Examples

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Embodiment Construction

[0044] The present invention is based at least in part on the discovery that certain solutions of amphiphilic peptides can surprisingly and advantageously be used in the treatment of cerebrospinal fluid leaks.

[0045] In various aspects and embodiments, the present invention provides methods and materials for the treatment of cerebrospinal fluid leaks. Treating a CSF leak may include blocking the opening through which CSF leaks. The openings through which CSF leaks can be holes or fissures in the dura mater. In some embodiments, treating a cerebrospinal fluid leak can result in a reduction of the cerebrospinal fluid leak or substantially prevent the cerebrospinal fluid leak.

[0046] In various aspects and embodiments, the present invention provides methods and materials for occluding a cerebrospinal fluid leak (eg, blocking an opening through which cerebrospinal fluid leaks). The method comprises administering to a target area of ​​a cerebrospinal fluid leak an effective a...

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Abstract

Methods and materials for treating a cerebrospinal fluid leakage are described herein. One method for treating cerebrospinal fluid leakage includes occluding cerebrospinal fluid leakage by administering an effective amount of a self-assembling peptide solution to a target area of a cerebrospinal fluid leakage, where the self-assembling peptide is between 7 amino acids and 32 amino acids in lengthand the self-assembling peptide solution forms a hydrogel under physiological conditions.

Description

technical field [0001] The present disclosure generally relates to materials and methods useful in medical, research and industrial applications. More specifically, the present disclosure relates to materials and methods useful for occlusion of cerebrospinal fluid leaks. Background technique [0002] A cerebrospinal fluid leak occurs when holes or cracks in the dura mater allow leakage of cerebrospinal fluid. Cerebrospinal fluid leaks can occur during cerebrospinal and spinal surgery. Blood often leaks along with the fluid. Cerebrospinal fluid leaks are frequently observed during postoperative examination. It can lead to serious complications including bacterial meningitis. [0003] Conventional materials used to treat CSF leaks include expanded polytetrafluoroethylene (e-PTFE) sheets, fibrin glue, and collagen. However, existing materials for treating CSF leaks may not have sufficient efficacy and / or have undesired complications. The use of e-PTFE sheets may allow lea...

Claims

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Application Information

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IPC IPC(8): A61L24/00A61L24/10
CPCA61L24/0031A61L24/108A61L2430/36A61K38/03A61K38/08A61K38/10A61K38/16A61L2400/06C07K14/00
Inventor 小林智
Owner 3 D MATRIX
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