Cerebrospinal fluid leakage occlusion

Abstract

Methods and materials for treating a cerebrospinal fluid leakage are described herein. One method for treating cerebrospinal fluid leakage includes occluding cerebrospinal fluid leakage by administering an effective amount of a self-assembling peptide solution to a target area of a cerebrospinal fluid leakage, where the self-assembling peptide is between 7 amino acids and 32 amino acids in lengthand the self-assembling peptide solution forms a hydrogel under physiological conditions.

Description

technical field [0001] The present disclosure generally relates to materials and methods useful in medical, research and industrial applications. More specifically, the present disclosure relates to materials and methods useful for occlusion of cerebrospinal fluid leaks. Background technique [0002] A cerebrospinal fluid leak occurs when holes or cracks in the dura mater allow leakage of cerebrospinal fluid. Cerebrospinal fluid leaks can occur during cerebrospinal and spinal surgery. Blood often leaks along with the fluid. Cerebrospinal fluid leaks are frequently observed during postoperative examination. It can lead to serious complications including bacterial meningitis. [0003] Conventional materials used to treat CSF leaks include expanded polytetrafluoroethylene (e-PTFE) sheets, fibrin glue, and collagen. However, existing materials for treating CSF leaks may not have sufficient efficacy and / or have undesired complications. The use of e-PTFE sheets may allow lea...

AI Technical Summary

Problems solved by technology

Epidural blood patches can be used for blockage, but they can cause complications such as postoperative adhesions due to blood injection and painful neuritis

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