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Plasma protein markers for predicting the risk of acute mountain sickness and their application in the preparation of diagnostic ams susceptibility kits

A technology for a diagnostic kit and plasma protein is applied in the application field of preparing diagnostic reagents or kits for susceptibility to acute mountain sickness, which can solve problems such as inconvenient operation, unfavorable popularization and application, and avoid the toxic and side effects of drugs and prevent the inconvenience of preventive measures. full effect

Active Publication Date: 2021-04-06
中国人民解放军联勤保障部队第九四〇医院
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Problems solved by technology

However, this method needs to expose the test population to the plateau field or a simulated oxygen chamber. Hypoxia will induce a large amount of protein, which may cover up low-abundance acute mountain sickness biomarkers; secondly, this method is limited by platform conditions. Inconvenient, not conducive to the promotion of applications
At present, there are no literature reports on the markers applied to the risk diagnosis of acute mountain sickness

Method used

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  • Plasma protein markers for predicting the risk of acute mountain sickness and their application in the preparation of diagnostic ams susceptibility kits

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Embodiment Construction

[0029] Now, the present invention will be described in detail in conjunction with the embodiments and accompanying drawings, but the implementation of the present invention is not limited thereto.

[0030] The reagents and raw materials used in the present invention are commercially available or can be prepared according to literature methods. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. Percentages and parts are by volume unless otherwise indicated.

[0031] 1. Material and Specimen Collection Description

[0032] In order to verify the association between plasma protein molecules and AMS, two groups of experimenters were recruited for the experiment. The first batch of 23 plain subjects were recruited. Plasma samples of AMS-susceptible subjects were collected from AMS patients who entered the plateau rapidly. Before the plateau, ther...

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Abstract

The invention relates to the technical field of medical biological detection, and provides a plasma protein marker for predicting the risk of acute mountain sickness and the application of the plasma protein marker in preparing a diagnostic reagent or a diagnostic kit for susceptibility to acute mountain sickness. The plasma protein marker of the present invention is a combination of plasma proteins ACADL, ACADM, ASS1, ATP11C, CANX, DDX3X, HMGB1, HSP90AA1, PSMC2 and RAN. The present invention further provides a kit and a detection method utilizing the susceptibility diagnosis of acute mountain sickness. The kit and detection method of the present invention are simple, reliable, short in cycle, high in specificity, and easy for clinical promotion.

Description

technical field [0001] The invention relates to the technical field of medical biological detection, and relates to a plasma protein marker for predicting the risk of acute mountain sickness, and the application of the plasma protein marker in the preparation of acute mountain sickness susceptibility diagnostic reagents or kits. By detecting the plasma protein marker To predict the risk of acute mountain sickness, so as to evaluate the susceptibility of human body to acute mountain sickness. Background technique [0002] People in plains are prone to acute mountain sickness (acute mountainsickness, AMS) when they enter high altitude areas (≥2500m) rapidly. AMS is a self-limiting disease with headache as the main symptom accompanied by gastrointestinal discomfort, dizziness, fatigue and insomnia. Its incidence rate is much higher than that of primary pulmonary edema and high altitude cerebral edema. Studies have shown that when rapidly ascending (1000m / d-1600m / d) to areas ab...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/40G01N2800/60
Inventor 鹿辉王荣熊娟贾正平
Owner 中国人民解放军联勤保障部队第九四〇医院
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