Blood fat reducing effect of evodiamine

An evodiamine and blood lipid-lowering technology, which is applied in the medical field to achieve the effects of increasing the outflow of cholesterol and inhibiting the formation of atherosclerotic plaques

Inactive Publication Date: 2019-02-01
QINGDAO UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that evodiamine reduces serum triglyceride levels in mice, but there is no report that evodiamine regulates cholesterol efflux through the ABCA1 pathway to achieve the purpose of lowering blood lipids

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Blood fat reducing effect of evodiamine
  • Blood fat reducing effect of evodiamine
  • Blood fat reducing effect of evodiamine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention will be described in detail below in combination with specific embodiments.

[0021] 1. The hypolipidemic effect of evodiamine on lipid-bearing ICR mice.

[0022] Establishment of a fat-bearing mouse model: the mice were fed a high-fat diet (10% lard, 3% cholesterol, and 0.5% pig bile salt) for 3 weeks to establish a stable fat-bearing mouse model. The ICR mice used were purchased from Beijing Weitong Lihua Company.

[0023] Administration and measurement: the mice were randomly divided into 4 groups. They were: common feed-control group, common feed-evodiamine group, high-fat feed-control group and high-fat feed-evodiamine group. The evodiamine group was given 10 mg / kg of evodiamine, and the control group was given corresponding solvents. After feeding the mice for 8 weeks, they were sacrificed and serum was collected. The levels of total TC, total TG, HDL-C and LDL-C in serum were determined by single reagent GPO-PAP method.

[0024] Results...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses blood fat reducing effect of evodiamine. Evodiamine is capable of reducing blood fat through increasing human THP-1 macrophage cholesterol outflow, and cholesterol outflow regulation is realized through inhibition on ABCA1 protein degradation and activation of TRPV1 acceptor. The beneficial effects are that: new target points are provided for prevention and treatment of atherosclerosis, and a convenient approach is provided for further development of novel blood fat reducing medicines or health care products.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the blood lipid-lowering effect of evodiamine. Background technique [0002] Atherosclerosis (AS) is a general term for degenerative and proliferative lesions in which the arterial wall thickens, hardens, loses elasticity and narrows the lumen. The occurrence of AS is closely related to hyperlipidemia, mainly due to the abnormal increase of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and other lipids in serum, and in the arteries Deposition on the membrane leads to thickening and hardening of the arterial wall, narrowing of the lumen, and a decrease in the blood supply level of the blood supplying organs. Cardiovascular disease (CVD) caused by AS is the number one cause of death in the world today, and it is also the number one cause of death among Chinese residents. At present, the number of deaths due to CVD in my country is about 3.7 ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P3/06
CPCA61K31/519A61P3/06
Inventor 王李梅王克威侯兴明
Owner QINGDAO UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap