Skin and mucosa disinfectant and preparation method thereof

A disinfectant and mucous membrane technology, applied in skin diseases, pharmaceutical formulations, local antibacterial agents, etc., can solve the problems of inappropriate wound disinfection, strong irritation, allergies, etc., to promote the activity of immune cells, enhance antibacterial activity, and stimulate The effect of cell proliferation

Inactive Publication Date: 2019-02-12
湖南中威制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Single-component disinfectants on the market, such as alcohol disinfectants, aldehyde disinfectants, peroxide disinfectants, and iodine, are highly irritating and are generally not suitable for disinfection of mucous membranes, wounds, and wounds. Alcohol-based or aldehyde-based disinfectants can cause problems such as dry and cracked skin
[0003] The patent application number CN104621104A discloses a composite disinfectant, the main component of which is the compound of o-phthalaldehyde and benzalkonium chloride and other single- and double-chain quaternary ammonium salts, which can kill bacteria on medical devices in a very short time , fungi, viruses and other microorganisms, but this product has certain irritation, may cause allergies, and is not suitable for disinfection of skin, mucous membranes and wounds
[0004] Therefore, under the premise of ensuring the disinfection effect, how to avoid the problem of greater damage to the skin and mucous membranes and low safety is the focus of current researchers.

Method used

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  • Skin and mucosa disinfectant and preparation method thereof
  • Skin and mucosa disinfectant and preparation method thereof
  • Skin and mucosa disinfectant and preparation method thereof

Examples

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preparation example Construction

[0054] The present invention provides the preparation method of skin mucous membrane disinfectant described in above-mentioned technical solution, comprises the following steps:

[0055] mixing the skin penetration enhancer and the alcohol synergist to obtain the first mixed liquid;

[0056] mixing the wound healing agent with water to obtain a second mixed solution;

[0057] Mix benzalkonium chloride, didecyldimethylammonium chloride, disodium edetate, stabilizer, pH buffer and water to obtain a third mixed solution;

[0058] The first mixed solution, the second mixed solution and the third mixed solution are mixed and then left to stand and filtered in sequence, and the obtained filtrate is a skin and mucous membrane disinfectant.

[0059] In the present invention, the skin penetration enhancer is mixed with the alcohol synergist to obtain the first mixed solution. In the present invention, the mixing is preferably carried out under stirring conditions; the present inventi...

Embodiment 1

[0068] Weigh each material according to the specific gravity of each component in Table 1;

[0069] Under stirring conditions, menthol is dissolved in propylene glycol to obtain the first mixed solution;

[0070] Dissolve chitosan quaternary ammonium salt and allantoin in purified water (50° C.) under stirring conditions to obtain a second mixed solution;

[0071] Under stirring conditions, benzalkonium chloride (C 12 h 25 -C 9 h 13 NCl, C 14 h 29 -C 9 h 13 NCl and C 16 h 33 -C 9 h 13 The molar ratio of NCl is 40:50:10), didecyldimethylammonium chloride, sodium acetate, 1mol / L acetic acid solution and disodium edetate were dissolved in purified water (room temperature) to obtain the third mixed solution;

[0072] Under the condition of stirring, the first mixed solution, the second mixed solution and the third mixed solution were uniformly mixed, then stood still for 12 hours, filtered, and the obtained filtrate was filled to obtain a finished skin and mucous memb...

Embodiment 2

[0077] Weigh each material according to the specific gravity of each component in Table 2;

[0078] Under stirring conditions, menthol is dissolved in propylene glycol to obtain the first mixed solution;

[0079] Dissolve allantoin in purified water (50°C) under stirring to obtain a second mixed solution;

[0080] Under stirring conditions, benzalkonium chloride (C 12 h 25 -C 9 h 13 NCl, C 14 h 29 -C 9 h 13 NCl and C 16 h 33 -C 9 h 13 The molar ratio of NCl is 40:50:10), didecyldimethylammonium chloride, NaH 2 PO 4 、Na 2 HPO 4 and disodium edetate were dissolved in purified water (room temperature) to obtain the third mixed solution;

[0081] Under the condition of stirring, the first mixed solution, the second mixed solution and the third mixed solution were uniformly mixed, then stood still for 12 hours, filtered, and the obtained filtrate was filled to obtain a finished skin and mucous membrane disinfectant with a pH value of 7.5.

[0082] Composition and c...

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Abstract

The invention provides a skin and mucosa disinfectant. In the skin and mucosa disinfectant provided by the invention, benzalkonium chloride and didoctyl dimethyl ammonium chloride are safe and irritation-free surfactants and are matched to use so that the antibacterial activity is enhanced and the disinfectant has a debridement effect on wounds; in a nursing process of the wounds, a wet healing environment is provided for the wounds, so that the releasing of growth factors is easy to promote, cell proliferation is stimulated, an activation function of immune cells is promoted to be enhanced and the healing of the wounds is accelerated. Menthol crystal acts on skin or mucosa and has the effects of cooling and stopping itching; borneol has the effects of clearing away heat and stopping pains, and promoting granulation; chitosan, a chitosan derivative, allantoin and aloe extract have anti-inflammatory and moisturizing effects, provide guarantees for skin care and wound repairing and are effectively combined with the benzalkonium chloride and the didoctyl dimethyl ammonium chloride, so that a good healing environment is provided for the wounds; the skin and mucosa disinfectant is usedfor disinfecting the skin and the mucosa and also has moisturizing and repairing effects.

Description

technical field [0001] The invention relates to the technical field of disinfectants, in particular to a skin and mucous membrane disinfectant and a preparation method thereof. Background technique [0002] With the continuous improvement of living standards, people pay more and more attention to disease prevention and environmental health issues, and have higher and higher requirements for the aesthetics of wound recovery. Single-component disinfectants on the market, such as alcohol disinfectants, aldehyde disinfectants, peroxide disinfectants, and iodine, are highly irritating and are generally not suitable for disinfection of mucous membranes, wounds, and wounds. Alcohol-based or aldehyde-based disinfectants can cause problems such as dry and cracked skin. [0003] The patent application number CN104621104A discloses a composite disinfectant, the main component of which is the compound of o-phthalaldehyde and benzalkonium chloride and other single- and double-chain quat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/886A61K36/896A61K47/10A61K47/18A61P17/00A61P31/02A61K31/045A61K31/14A61K31/4166A61K31/722
CPCA61K31/045A61K31/14A61K31/4166A61K31/722A61K36/886A61K36/896A61K47/10A61K47/183A61P17/00A61P31/02A61K2300/00
Inventor 姜明姣常国树
Owner 湖南中威制药有限公司
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