Skin and mucosa disinfectant and preparation method thereof
A disinfectant and mucous membrane technology, applied in skin diseases, pharmaceutical formulations, local antibacterial agents, etc., can solve the problems of inappropriate wound disinfection, strong irritation, allergies, etc., to promote the activity of immune cells, enhance antibacterial activity, and stimulate The effect of cell proliferation
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[0054] The present invention provides the preparation method of skin mucous membrane disinfectant described in above-mentioned technical solution, comprises the following steps:
[0055] mixing the skin penetration enhancer and the alcohol synergist to obtain the first mixed liquid;
[0056] mixing the wound healing agent with water to obtain a second mixed solution;
[0057] Mix benzalkonium chloride, didecyldimethylammonium chloride, disodium edetate, stabilizer, pH buffer and water to obtain a third mixed solution;
[0058] The first mixed solution, the second mixed solution and the third mixed solution are mixed and then left to stand and filtered in sequence, and the obtained filtrate is a skin and mucous membrane disinfectant.
[0059] In the present invention, the skin penetration enhancer is mixed with the alcohol synergist to obtain the first mixed solution. In the present invention, the mixing is preferably carried out under stirring conditions; the present inventi...
Embodiment 1
[0068] Weigh each material according to the specific gravity of each component in Table 1;
[0069] Under stirring conditions, menthol is dissolved in propylene glycol to obtain the first mixed solution;
[0070] Dissolve chitosan quaternary ammonium salt and allantoin in purified water (50° C.) under stirring conditions to obtain a second mixed solution;
[0071] Under stirring conditions, benzalkonium chloride (C 12 h 25 -C 9 h 13 NCl, C 14 h 29 -C 9 h 13 NCl and C 16 h 33 -C 9 h 13 The molar ratio of NCl is 40:50:10), didecyldimethylammonium chloride, sodium acetate, 1mol / L acetic acid solution and disodium edetate were dissolved in purified water (room temperature) to obtain the third mixed solution;
[0072] Under the condition of stirring, the first mixed solution, the second mixed solution and the third mixed solution were uniformly mixed, then stood still for 12 hours, filtered, and the obtained filtrate was filled to obtain a finished skin and mucous memb...
Embodiment 2
[0077] Weigh each material according to the specific gravity of each component in Table 2;
[0078] Under stirring conditions, menthol is dissolved in propylene glycol to obtain the first mixed solution;
[0079] Dissolve allantoin in purified water (50°C) under stirring to obtain a second mixed solution;
[0080] Under stirring conditions, benzalkonium chloride (C 12 h 25 -C 9 h 13 NCl, C 14 h 29 -C 9 h 13 NCl and C 16 h 33 -C 9 h 13 The molar ratio of NCl is 40:50:10), didecyldimethylammonium chloride, NaH 2 PO 4 、Na 2 HPO 4 and disodium edetate were dissolved in purified water (room temperature) to obtain the third mixed solution;
[0081] Under the condition of stirring, the first mixed solution, the second mixed solution and the third mixed solution were uniformly mixed, then stood still for 12 hours, filtered, and the obtained filtrate was filled to obtain a finished skin and mucous membrane disinfectant with a pH value of 7.5.
[0082] Composition and c...
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