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Cyclobenzaprine hydrochloride slow release capsules and preparation method thereof

A technology of cyclobenzaprine hydrochloride and sustained-release capsules, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., which can solve the problems of frequent medication, fast oral absorption, and the impact of medication compliance on patients Sex and other problems, to achieve the effect of improving the analgesic effect

Inactive Publication Date: 2019-02-15
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, both cyclobenzaprine hydrochloride and diclofenac sodium have the problems of rapid oral absorption and short biological half-life, and their common dosage forms require multiple medications per day, which affects the compliance of patients with medication.
At present, there are no studies and reports on the joint preparation of sustained-release preparations of cyclobenzaprine hydrochloride and diclofenac sodium

Method used

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  • Cyclobenzaprine hydrochloride slow release capsules and preparation method thereof
  • Cyclobenzaprine hydrochloride slow release capsules and preparation method thereof
  • Cyclobenzaprine hydrochloride slow release capsules and preparation method thereof

Examples

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Embodiment Construction

[0024] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. All percentages, ratios, proportions or parts are by weight unless otherwise indicated.

[0025] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as are familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described can be applied to the method of the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only.

[0026] The preparation of embodiment cyclobenzaprine hydrochlor...

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Abstract

The invention relates to the field of pharmaceutical preparations, in particular to cyclobenzaprine hydrochloride slow release capsules and a preparation method thereof. The cyclobenzaprine hydrochloride slow release capsules comprise active ingredients, a slow release material, a diluent, a binder, a disintegrant and a lubricant, wherein the active ingredients comprise cyclobenzaprine hydrochloride and diclofenac sodium. By optimizing and screening the formula of the cyclobenzaprine hydrochloride slow release capsules, determining the composition of the auxiliary materials and selecting cyclobenzaprine hydrochloride and diclofenac sodium as the active ingredients to prepare the slow release capsules, the defect that frequent dosing is needed as the half life periods of cyclobenzaprine hydrochloride and diclofenac sodium are short is overcome. In addition, the analgesic effect can be improved by combined use of cyclobenzaprine hydrochloride and diclofenac sodium, so that an unexpectedtechnical effect is achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cyclobenzaprine hydrochloride sustained-release capsule and a preparation method thereof. Background technique [0002] Cyclobenzaprine hydrochloride (cyclobenzaprine hydrochloride, 1), the chemical name is 5-(3-dimethylaminopropylene) dibenzo [a, d] cycloheptene hydrochloride, is a muscle The relaxant is now on the market in many countries, and the trade name is Flexeril. [0003] Cyclobenzaprine hydrochloride is a central muscle relaxant, and its action site may be in the brainstem, not a ganglion muscle blocking agent. After administration, skeletal muscle relaxation occurs. Cyclobenzaprine hydrochloride also has an anticholinergic effect. It can relieve the symptoms of local muscle spasms without interfering with the normal function of muscles, and is ineffective for muscle spasms caused by central nervous system diseases. Clinically, it is mainly used as an adj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/32A61K47/34A61K31/137A61K31/196A61P29/00
CPCA61K9/1635A61K9/1641A61K31/137A61K31/196A61P29/00A61K2300/00
Inventor 陈阳生王明刚孙桂玉刘晓霞杜昌余王清亭刘振玉臧云龙
Owner CP PHARMA QINGDAO CO LTD