Application of a group of serum differential protein combinations in the preparation of reagents for detecting Alzheimer's disease

A technology of Alzheimer's disease and differential protein, applied in the application field of reagents, can solve the problems of detection delay or misdiagnosis, and achieve the effect of improving objectivity

Active Publication Date: 2022-04-15
SHENZHEN UNIV
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Problems solved by technology

[0004] In view of the deficiencies in the prior art above, the purpose of the present invention is to provide the application of a set of serum protein combinations in the preparation of reagents for detecting Alzheimer's disease, aiming to solve the problem that existing detection methods have certain subjectivity, which is easy to cause Detecting Delayed or Misdiagnosed Issues

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  • Application of a group of serum differential protein combinations in the preparation of reagents for detecting Alzheimer's disease
  • Application of a group of serum differential protein combinations in the preparation of reagents for detecting Alzheimer's disease
  • Application of a group of serum differential protein combinations in the preparation of reagents for detecting Alzheimer's disease

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Embodiment 1

[0034] The present invention uses a combination of computational prediction and experimental verification to identify blood protein markers that can be used for AD diagnosis: first, by comparing and analyzing the transcriptome data of existing Alzheimer's disease patients and normal human brain tissues, Obtain the differentially expressed genes related to Alzheimer's disease; secondly, use the blood protein prediction program to analyze the secreted proteins encoded by the genes related to Alzheimer's disease into the blood, and obtain the blood proteins related to Alzheimer's disease; then, Through the functional analysis of Alzheimer's disease-related blood proteins, potential Alzheimer's disease blood protein markers were selected; finally, blood samples from Alzheimer's patients and normal people were collected, and enzyme-linked immunoassay (ELISA) ) to test these proteins. Therefore, the technical solution of the present invention has higher sensitivity and better specif...

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Abstract

The invention discloses the application of a group of serum differential protein combinations in the preparation of reagents for detecting Alzheimer's disease, wherein the serum differential protein combinations are GSN protein, BDNF protein, TIMP1 protein, VLDLR protein and APLP2 protein Any combination of 3 or more proteins. The present invention determines a serum differential protein combination that can be used to detect Alzheimer's disease, and using the serum protein combination to prepare a reagent for detecting Alzheimer's disease can improve the objectivity, specificity and accuracy of detection.

Description

technical field [0001] The invention relates to the technical field of reagent application, in particular to the application of a group of serum differential protein combinations in the preparation of reagents for detecting Alzheimer's disease. Background technique [0002] Alzheimer's Disease (AD), also known as senile dementia, is a neurodegenerative disease, and its incidence rate increases year by year with the increase of population age. Since the pathogenesis of Alzheimer's disease is still unclear and there is a lack of effective treatment drugs, early detection is crucial to curbing or delaying the progression of the disease. The current detection of Alzheimer's disease is mainly based on scales, clinical symptoms, descriptions of patients or family members, clinical experience of clinicians, etc., which has a certain degree of subjectivity and may easily cause delays in diagnosis or misdiagnosis. Therefore, finding fast and effective detection reagents is of great ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68
CPCG01N33/6896
Inventor 姚芳沈立明刘琼
Owner SHENZHEN UNIV
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