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Manufacturing process of sealed negative pressure drainage wet sponge

A negative pressure drainage and manufacturing process technology, applied in the field of medical sponges, can solve problems such as the increase of reducing substances, the destruction of molecular cross-linking points, the inability to meet the biosafety requirements of deep cavity wounds, etc., achieving high biosafety and speeding up healing time. Effect

Active Publication Date: 2021-04-20
WUHAN VSD MEDICAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the introduction of high-energy electron beams in the sterilization process, the aging of the sponge product will be accelerated, the cross-linking point of the molecule will be destroyed, and some small molecular substances will be decomposed, resulting in a decrease in the pH of the product and an increase in the reducing substances in the product. Such a sponge is used in On the wound surface, it not only provides a strong acid environment and destroys the growth process of granulation tissue, but the reducing substances in the sponge product can also cause the cytotoxicity test range of the sponge product to be low, which is not conducive to wound healing
[0004] Since irradiation sterilization exhibits the aforementioned problems, it cannot meet the biosafety requirements for use in deep cavity wounds

Method used

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  • Manufacturing process of sealed negative pressure drainage wet sponge
  • Manufacturing process of sealed negative pressure drainage wet sponge
  • Manufacturing process of sealed negative pressure drainage wet sponge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation method of embodiment 1 polyvinyl alcohol sponge 3 is as follows:

[0034] Mix 1 kg of 10% wt polyvinyl alcohol aqueous solution and 10 ml of formaldehyde under acidic conditions in a reactor at a temperature of 15 to 25 ° C and a stirring rate of 200 to 300 RPM for 6 to 30 minutes, then stir at a stirring rate of 100 Stir for 2-10 minutes at ~200RPM, add a cross-linking agent, and cure at 50-85°C for 12-48 hours; cut the prepared sponge, wash it, and dry it using a microwave drying process at a vacuum degree of -0.5~ 1MPa, the temperature is -30~50℃, and the time is 1~3h.

Embodiment 2

[0036] The manufacturing process of the sealed negative pressure drainage wet sponge comprises the following steps:

[0037] 1) Sterilization: put the dry polyvinyl alcohol sponge 3 into the head bag 1, and connect the head bag 1 with the liquid storage chamber 2 through the connecting pipe 4, and seal it; then put the polyvinyl alcohol sponge 3 into Header bag 1 is sent into an environment containing ethylene oxide gas, and ethylene oxide gas enters the pair of polyvinyl alcohol sponges 3 of header bag 1 through the hole on the Tyvek paper 1.2 surface of header bag 1, and the temperature is 50°C. Fumigate and sterilize for 4 hours, and then stand still in a ventilated environment; wherein, one side of the plug bag 1 is transparent plastic 1.1, and the other side is made of transparent plastic 1.1 and Tyvek paper 1.2, and Tyvek paper 1.2 is the plug the upper part of one side of bag 1;

[0038] 2) Rehydration: Put the sterilized product in sealed packaging, and put it outside...

Embodiment 3

[0040] The manufacturing process of the sealed negative pressure drainage wet sponge comprises the following steps:

[0041] 1) Sterilization: put the dry polyvinyl alcohol sponge 3 into the head bag 1, and connect the head bag 1 with the liquid storage chamber 2 through the connecting pipe 4, and seal it; then put the polyvinyl alcohol sponge 3 into Header bag 1 is sent into an environment containing ethylene oxide gas, and ethylene oxide gas enters the pair of polyvinyl alcohol sponges 3 of header bag 1 through the hole on the Tyvek paper 1.2 surface of header bag 1, and the temperature is 45°C. Fumigate and sterilize for 4 hours, and then stand still in a ventilated environment; wherein, one side of the header bag 1 is made of transparent plastic 1.1, and the other side is made of transparent plastic 1.1 and Tyvek paper 1.2, and the Tyvek paper 1.2 is the header bag 1 the middle of one side;

[0042] 2) Rehydration: Put the sterilized product in sealed packaging, and put i...

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Abstract

The invention discloses a manufacturing process of a sealed negative pressure drainage wet sponge. In the process, the dry polyvinyl alcohol sponge is packed into a head bag, and the head bag is connected with a liquid storage chamber through a connecting pipe and sealed; Fumigate and sterilize in the environment of oxyethane gas, and then seal the packaged product after sterilization, and unscrew the one-way valve in the top bag through the top bag outside the top bag, so that the liquid in the liquid storage tank is injected into the sponge On the surface, after the liquid is injected, pull out the connecting tube and the liquid storage tank, seal the part of the head bag containing the polyvinyl alcohol sponge, and then cut off the part of the head bag containing the Tyvek paper and the liquid storage tank to obtain a negative pressure Drain wet sponge. The process of the present invention rehydrates the polyvinyl alcohol sponge package to obtain a negative pressure drainage wet sponge, which has excellent cytotoxicity and a pH close to neutral, and provides a good growth environment for the granulation tissue required for wound healing, thereby maintaining Patient comfort, for surface and body cavity wound repair.

Description

technical field [0001] The invention relates to the field of medical sponges, in particular to a manufacturing process of a sealed negative pressure drainage wet sponge. Background technique [0002] With the popularization of negative pressure drainage technology, the application of negative pressure drainage sponge is gradually widespread: from body surface application to deep cavity wound application, and the application of deep cavity wound has higher biological safety requirements for negative pressure drainage sponge. Therefore it is particularly important to make high-performance negative pressure drainage sponge. [0003] At present, most of the commercially available negative pressure drainage sponges adopt the irradiation sterilization process, and the irradiation sterilization achieves the effect of killing bacteria by providing electron beams and energy. However, due to the introduction of high-energy electron beams in the sterilization process, the aging of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/02A61L2/20A61L101/44
CPCA61L2/206A61F13/00072A61F13/00987A61L2202/21A61F13/05
Inventor 朱玉明肖进
Owner WUHAN VSD MEDICAL SCI & TECH CO LTD
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