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Fructus rosae laevigatae standard decoction lyophilized powder and production process thereof

A production process and freeze-dried powder technology, applied in the field of Jinyingzi standard decoction freeze-dried powder and its production technology, can solve the problems of collapse, high viscosity of freeze-dried powder, unable to achieve ideal freeze-drying effect, etc., and achieve smooth surface. , Low hygroscopicity, and the effect of improving freeze-drying rate and hygroscopicity

Inactive Publication Date: 2019-02-22
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the freeze-drying process of preparing standard decoctions of most traditional Chinese medicines does not need to add protective agents, but for freeze-dried powders with large sugar content, the viscosity is too high and the collapse is serious, and the ideal freeze-drying effect cannot be achieved.

Method used

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  • Fructus rosae laevigatae standard decoction lyophilized powder and production process thereof
  • Fructus rosae laevigatae standard decoction lyophilized powder and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A standard decoction freeze-dried powder of Fructus Rosa Fructus, take 2 mL of standard decoction of Fructus Rosa Fructus, add 10% freeze-drying protective agent, freeze-dry to obtain freeze-dried powder. The lyoprotectant is maltodextrin. The density of described Fructus Rosa Rosa standard decoction is 1g / mL. The freezing temperature of the freeze-drying is -50°C, and the freezing time is not less than 3 hours; after the freezing is completed, the temperature is raised to -35°C within 8 minutes, and after being maintained for 20 hours, the temperature is raised to -30°C and maintained for 18 hours; Keep at -20°C for 10 hours, continue to raise the temperature to -10°C, and keep for 5 hours; raise the temperature to 30°C within 8 minutes for analysis and drying.

[0023] Adding a freeze-drying protective agent into a certain amount of standard decoction of Rosa chinensis can effectively prevent the freeze-dried product from excessive viscosity and serious collapse duri...

Embodiment 2

[0026] The difference between Example 2 and Example 1 is that 2 mL of the standard decoction of Fructus Rosa Radix is ​​taken, 1% of lyoprotectant is added, and the lyophilized powder can be obtained after lyophilization. The lyoprotectant is maltodextrin. The freezing temperature of the freeze-drying is -55°C, and the freezing time is not less than 2 hours; after the freezing is completed, the temperature is raised to -40°C within 5 minutes, and after being maintained for 15 hours, the temperature is raised to -33°C and maintained for 15 hours; Keep at -25°C for 5 hours, continue to raise the temperature to -15°C, and keep for 3 hours; within 5 minutes, raise the temperature to 20°C for analysis and drying.

[0027] The sublimation temperature is set to -40°C and -30°C, the production efficiency is high and the product quality is good. Catechin has various functions such as anti-tumor, anti-oxidation, anti-bacteria, and protection of heart and brain organs. The freeze-dried ...

Embodiment 3

[0029] The difference between Example 3 and Example 1 is that 2 mL of the standard decoction of Fructus Rosa Rosa Fructus is taken, 30% of lyoprotectant is added, and the lyophilized powder can be obtained after lyophilization. The lyoprotectant is maltodextrin. The freezing temperature of the freeze-drying is -45°C, and the freezing time is not less than 4 hours; after the freezing is completed, the temperature is raised to -32°C within 10 minutes, and after being maintained for 25 hours, the temperature is raised to -28°C and maintained for 20 hours; Keep at -15°C for 15 hours, continue to raise the temperature to -5°C, and keep for 10 hours; within 10 minutes, raise the temperature to 35°C for analysis and drying.

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Abstract

The invention relates to the field of deep processing of fructus rosae laevigatae and provides fructus rosae laevigatae standard decoction lyophilized powder and a production process thereof and solves the problem that a fructus rosae laevigatae lyophilized powder product prepared by a conventional lyophilizing process is great in viscosity and collapses severely. The invention provides the fructus rosae laevigatae standard decoction lyophilized powder. The production process comprises the following steps: taking 1-5 mL of a fructus rosae laevigatae standard decoction; adding 1-30% of a freeze-drying protective additive; and freezing and drying the mixture to obtain the lyophilized powder. By adding the freeze-drying protective additive, the prepared lyophilized powder is smooth in surface, uniform in color and luster and small in hygroscopicity, and the product quality is improved effectively.

Description

technical field [0001] The invention relates to the field of deep processing of Fructus Rosa Fructus, in particular to a standard decoction freeze-dried powder of Fructus Rosa Fructus and its production process. Background technique [0002] Rosa laevigata Michx (Rosa laevigata Michx) is the dried and mature fruit of Rosa laevigata Michx, which has the effect of clearing away heat and detoxifying. Rosaceae plants are widely distributed in the sunny slope shrubs at an altitude of 50-1600m in Central China, South China, Southeast my country and Southwest China. Fructus Rosa Rosa is a fruit tonic. According to the relevant requirements of "Standard Decoction Preparation" in "Technical Requirements for Quality Control and Standard Formulation of Traditional Chinese Medicine Formula Granules", refer to the "Management Regulations for Traditional Chinese Medicine Decoction Rooms in Medical Institutions" by the Ministry of Health and the State Administration of Traditional Chinese ...

Claims

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Application Information

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IPC IPC(8): A61K36/738A61K9/19A61K47/36A61P15/00
CPCA61K9/19A61K36/738A61K47/36A61P15/00
Inventor 杨晓东黎晓丽罗宇琴王碧君丁青黄小丹周湘媛何嘉莹陈向东
Owner GUANGDONG YIFANG PHARMA