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Composition for alleviating osteoarthritis and preparation method and use thereof

A bone joint and composition technology, which is applied in the field of compositions for relieving osteoarthritis, can solve problems such as adverse reactions, achieve the effects of relieving pain symptoms and swelling, facilitating industrial production, and stabilizing quality

Pending Publication Date: 2019-03-01
江苏菌钥生命科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing drugs for relieving or eliminating pain are mainly non-steroidal anti-inflammatory drugs, such as ibuprofen, ketoprofen or rofecoxib, etc. However, when the above drugs are widely used, various adverse reactions have appeared

Method used

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  • Composition for alleviating osteoarthritis and preparation method and use thereof
  • Composition for alleviating osteoarthritis and preparation method and use thereof
  • Composition for alleviating osteoarthritis and preparation method and use thereof

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Experimental program
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Effect test

preparation example Construction

[0053] The preparation method of the invention can be easily compressed into tablets with suitable hardness, and the prepared tablets have suitable dissolution rate and disintegration time limit, which is beneficial to improve bioavailability; meanwhile, the quality stability of the compressed tablets is high, and is suitable for industrial production.

[0054] The present invention also provides the use of the above composition in the preparation of medicine for alleviating osteoarthritis. The osteoarthritis can be caused by gout, rheumatoid arthritis, lumbar disc herniation and degenerative diseases. The effect of the composition of the present invention on relieving osteoarthritis is mainly reflected in the improvement effect on relieving joint pain, reducing joint swelling and increasing the range of motion of joints.

Embodiment 1

[0057] The formulation of the tablet for the relief of osteoarthritis is as follows:

[0058] Inula officinalis extract 19g, galangal extract 85g, turmeric extract 245g, olive fruit extract 115g, papaya extract 155g, microcrystalline cellulose 210g, lactose 168g and magnesium stearate 5g.

[0059] Tablets are prepared as follows:

[0060] (1) Pass 19g of Inula inula officinalis extract, 85g of galangal extract, 245g of turmeric extract, 115g of olive fruit extract, 155g of papaya extract, 190g of microcrystalline cellulose and 168g of lactose through an 80-mesh sieve;

[0061] (2) Put the sieved material into a mixer and mix for 30 minutes, add pure water for wet granulation to obtain primary granules; transfer the primary granules to a fluidized granulation dryer, Drying under conditions for 45min, and then sizing to 16 mesh sieves to obtain granules;

[0062] (3) above-mentioned granule and magnesium stearate 5g, microcrystalline cellulose 20g are mixed 25min, tabletting o...

Embodiment 2

[0064] The formulation of the tablet for the relief of osteoarthritis is as follows:

[0065] Inula officinalis extract 15g, galangal extract 100g, turmeric extract 200g, olive fruit extract 140g, papaya extract 120g, microcrystalline cellulose 240g, lactose 150g and magnesium stearate 8g.

[0066] Tablets are prepared as follows:

[0067] (1) 15g of Inula officinalis extract, 100g of galanga extract, 200g of turmeric extract, 140g of olive fruit extract, 120g of papaya extract, 217g of microcrystalline cellulose and 150g of lactose were passed through an 80-mesh sieve;

[0068] (2) Put the sieved material into a mixer and mix for 30 minutes, add pure water for wet granulation to obtain primary granules; transfer the primary granules to a fluidized granulation dryer, Drying under conditions for 45min, and then sizing to 16 mesh sieves to obtain granules;

[0069] (3) The above-mentioned granules were mixed with 8 g of magnesium stearate and 23 g of microcrystalline cellulose...

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Abstract

The invention discloses a composition for alleviating osteoarthritis and a preparation method and use thereof. The composition comprises, by weight parts, 50-100 parts of galangal extract, 200-280 parts of turmeric extract, 100-140 parts of olive fruit extract and 120-200 parts of papaya extract. The composition has the effect of alleviating the osteoarthritis.

Description

technical field [0001] The invention relates to a composition for relieving osteoarthritis, a preparation method and application. Background technique [0002] Osteoarthritis is the degeneration of articular cartilage, reactive hyperplasia of joint edges and subchondral bone caused by aging, obesity, strain, trauma, congenital abnormalities of joints, joint deformities and many other factors. Osteoarthritis is a common joint disease, also known as osteoarthritis, degenerative arthritis and so on. Pain is the main symptom of the disease and the main cause of functional impairment. As the disease progresses, joint motion can be limited by pain, and pain can occur even at rest. [0003] Depending on the degree of development of the disease, the treatment of osteoarthritis includes drug therapy, adjuvant therapy and surgical treatment. For patients in the early and middle stages, drug therapy is generally adopted in combination with other methods of adjuvant therapy. The purp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P19/02A61P29/00
CPCA61K36/28A61K36/32A61K36/732A61K36/9062A61K36/9066A61P19/02A61P29/00A61K2300/00
Inventor 林峰潘迎春马涛张雨浩刘悦陈磊田雨蔡金文
Owner 江苏菌钥生命科技发展有限公司
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