Veterinary compound ivermectin injection and preparation method thereof

A technology of ivermectin and injection, which is applied in the field of veterinary compound ivermectin injection and its preparation, can solve the problems of short drug effect maintenance time, labor and material resources, easy to produce drug resistance, etc., and achieve the maintenance of drug resistance. Active, not easy to be infected, and the effect of improving the insecticidal effect

Inactive Publication Date: 2019-03-08
合肥中龙神力动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the veterinary ivermectins are common preparations at present, and the drug effect of each administration is short, and multiple administrations are required, which is inconvenient to use and consumes a lot of manpower and material resources. In addition, the single effective ingredients, will lead to a narrow spectrum of insecticidal, easy to produce drug resistance

Method used

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  • Veterinary compound ivermectin injection and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0021] A compound ivermectin injection for veterinary use, the preparation raw materials include 0.5% ivermectin, 1% monepal, 2% albendazole sulfoxide hydrochloride, 0.2% suspending agent, 0.08% emulsifier, 0.01% metal complexing agent, and 96.21% composite solvent;

[0022] Wherein, the suspending agent selects methyl cellulose and Pluronic F-68; the emulsifier selects polysorbate-80; the metal complexing agent selects edetate disodium; The weight ratio is composed of isopropyl myristate:PVP K30:polyethylene glycol:water for injection=2:2:1:4.

Embodiment 2

[0024] A kind of veterinary compound ivermectin injection, the preparation raw material of veterinary compound ivermectin injection comprises 1% ivermectin, 2% monepal, 4.5% albendazole sulfoxide by weight Hydrochloride, 0.5% suspending agent, 0.25% emulsifier, 0.02% metal complexing agent, and 91.73% complex solvent;

[0025] Wherein, the suspending agent is selected from carboxymethyl cellulose and sodium alginate; the emulsifier is selected from lecithin; the metal complexing agent is selected from sodium calcium edetate; Propyl ester: PVP K30: polyethylene glycol: water for injection = 2:2:1:4 composition.

Embodiment 3

[0027] A kind of veterinary compound ivermectin injection, its preparation raw material comprises 1% ivermectin, 3% monepal, 6% albendazole sulfoxide hydrochloride, 0.7% suspending agent, 0.5% emulsifier, 0.04% metal complexing agent, and 88.76% composite solvent;

[0028] Wherein, the suspending agent is selected from polyvinylpyrrolidone, gelatin and sorbitol; the emulsifier is selected from polyoxyethylene castor oil and calcium dodecylbenzenesulfonate; the metal complexing agent is selected from cyclohexanediamine In sodium tetraacetate; the composite solvent is composed of isopropyl myristate: PVP K30: polyethylene glycol: water for injection=2:2:1:4 by weight ratio.

[0029] Above-mentioned each embodiment all adopts following method to prepare injection: step comprises

[0030] S1. Mix and stir isopropyl myristate, PVP K30, polyethylene glycol and water for injection to a clear state to obtain liquid A, and keep it warm at 45°C for later use;

[0031] S2. Disperse or ...

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Abstract

The invention discloses a veterinary compound ivermectin injection. The injection is prepared from raw materials in percentage by weight as follows: 0.5%-1% of ivermectin, 1%-3% of monepantel, 2%-6% of albendazole sulfoxide hydrochloride, 0.2%-0.7% of a suspending aid, 0.08%-0.5% of an emulsifier, 0.01%-0.04% of a metal complexing agent and the balance of a complex solvent. The complex solvent isprepared from isopropyl myristate, PVP K30, polyethylene glycol and injection water. The ivermectin, monepantel and albendazole sulfoxide hydrochloride are compounded as insecticidal effective components, the special complex solvent is adopted for preparation, drug activity can be maintained, the synergistic effect of drugs can be promoted, so that the insecticidal spectrum is enlarged, the insecticidal effect is improved, and production of drug resistance can be effectively retarded. Besides, the suspending aid, the emulsifier and the metal complexing agent are added to the injection, thus, the injection forms a stable system and cannot be oxidized easily.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a veterinary compound ivermectin injection and a preparation method thereof. Background technique [0002] Ivermectin (ivermectin, IVM), the molecular formula is C 48 h 74 o 14 , widely used for gastrointestinal nematodes, lung nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes, ear mites, scabies mites, heartworms and microfilariae of dogs, and poultry gastrointestinal nematodes and parasitic arthropods External parasites. Its deworming mechanism is to promote the release of γ-aminobutyric acid (GABA) from presynaptic neurons, open the Cl ion channel controlled by glutamate, enhance the permeability of the neural membrane to Cl, thereby blocking the transmission of nerve signals , and eventually nerve paralysis, so that the muscle cells lose the ability to contract, leading to the death of the parasite. [0003] Most of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/38A61K47/26A61K47/18A61K31/7048A61K31/277A61K31/4184A61P33/10A61P33/14
CPCA61K9/0019A61K9/08A61K31/277A61K31/4184A61K31/7048A61K47/18A61K47/26A61K47/38A61P33/10A61P33/14A61K2300/00
Inventor 乐其新明文庆刘红云江定丰汪学景熊美玲
Owner 合肥中龙神力动物药业有限公司
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