Liquid chromatography high-pressure resistant gradient valve and liquid chromatography liquid inlet system

Abstract

The invention discloses a liquid chromatography high-pressure resistant gradient valve and a liquid chromatography liquid inlet system. The liquid chromatography high-pressure resistant gradient valvecomprises a valve body and at least two high-pressure valves, wherein a mixing outlet and at least two interfaces are formed in the valve body, and each the interface is communicated with the mixingoutlet; each the interface is respectively connected with one of the high-pressure valves, each the high-pressure valve comprises an outer shell, a valve core, an elastic holding piece and an electriccontrol driving piece, a liquid inlet cavity, a liquid outlet cavity and a communication cavity which are sequentially communicated are formed in each the outer shell, a liquid inlet is formed in each the liquid inlet cavity, a liquid outlet is formed in each the liquid outlet cavity, and each the liquid outlet is connected with each the interface; the valve cores are arranged in the liquid outlet cavities in a movable manner; the elastic holding pieces are arranged in the liquid outlet cavities, and the elastic holding pieces are abutted against the valve cores to block the valve cores at the communication cavities; and the electric control driving pieces are arranged on the outer shells and are matched with the valve cores to drive the valve cores to move, and the electric control driving pieces drive the valve cores to open the communication cavities when receiving liquid inlet information. The liquid chromatography high-pressure resistant gradient valve has the characteristics ofhigh pressure resistance and gradient accuracy.

Description

Technical field [0001] The invention belongs to the field of liquid chromatography technical equipment, in particular to a liquid chromatography withstand high pressure gradient valve and a liquid chromatography inlet system. Background technique [0002] High performance liquid chromatography (HPLC) is often used in sample detection and analysis, as well as in the process of sample separation and purification. Generally, high performance liquid chromatography systems can withstand at least 42MPa pressure. High performance liquid chromatography is used for qualitative analysis based on the difference in retention behavior of the tested sample on the chromatographic column and the time when the sample is eluted by the solvent. Therefore, two or more solutions are often used as eluents, and linear gradients or linear gradients, as well as combinations of linear gradients and linear gradients, as well as the combination of linear gradients and linear gradients, are formed through t...

AI Technical Summary

Problems solved by technology

However, in this process, the four-way solenoid valve is prone to shock effects when it is working, resulting in inaccurate solution concentration gradients.

And the front end of the four-way solenoid valve is directly connected to the liquid storage bottle, and works under atmospheric pressure, the four-way solenoid valve cannot withstand high pressure, and the pressure difference with the high-pressure infusion pump is relatively large

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