Compound ganoderma lucidum spore powder and preparation method thereof

A technology of ganoderma spore powder and broken ganoderma spore powder, which is applied in the field of compound ganoderma spore powder and its preparation, can solve the problems of low critical relative humidity, poor production operability, and poor particle fluidity, and achieve short disintegration time limit and enhanced The effect of weak immunity and hygroscopicity of experimental animals

Inactive Publication Date: 2019-03-12
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the technical defects that current Chinese medicine extracts have strong hygroscopicity, low critical relative humidity, easy to stick into agglomerates, poor particle fluidity, and poor production operability, and provide a compound Ganoderma lucidum spore powder, the raw material of which is The ratio of drug and joint excipients can significantly improve the hygroscopicity

Method used

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  • Compound ganoderma lucidum spore powder and preparation method thereof
  • Compound ganoderma lucidum spore powder and preparation method thereof
  • Compound ganoderma lucidum spore powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The extract (broken Ganoderma lucidum spore powder: Astragalus extract: Ginseng extract: Ligustrum lucidum extract weight ratio is 15:8:6:4), microcrystalline cellulose and pregelatinized starch are respectively according to the weight ratio of 200: 24:6, 200:20:10, 200:15:15, 200:6:24 and 200:10:20 are mixed evenly, add an appropriate amount of purified water, stir to make a suitable soft material, granulate with a 20-mesh screen, and Dry under normal pressure at 65±5°C, control the water content of the granules below 5.0%, cool naturally to room temperature, sieve the granules with 20 mesh, and set aside.

[0035] Put particles with a thickness of about 2mm at the bottom of the measuring bottle with constant weight, weigh them accurately, put them in a desiccator with a relative humidity of 75% saturated sodium chloride solution, store them in a constant temperature box at 40°C, and weigh them regularly. Calculate percent moisture absorption.

[0036] The fluidity of...

Embodiment 2

[0047] In order to further verify the above experimental results, different single excipients and preliminarily determined specific ratios of microcrystalline cellulose and pregelatinized starch were mixed with extracts to prepare hard capsules.

[0048] The specific method is: take 366.67g of dry extract powder of the extract (the weight ratio of broken Ganoderma lucidum spore powder: Astragalus extract: Ginseng extract: Ligustrum lucidum extract is 15:8:6:4), add 55g of auxiliary materials, and mix well , granulate, add an appropriate amount of silicon dioxide, mix well, fill 1000 capsules, take 10 capsules of the above-mentioned granules, pour them out and place them in the environment of the above-mentioned humidity measurement, measure the percentage of moisture absorption after 20 hours according to the above-mentioned method, and measure the disintegration of the hard capsule Whether the time limit complies with the provisions of the 2015 edition of the Chinese Pharmacop...

Embodiment 3

[0054] Formula: 166.67g of broken Ganoderma lucidum spore powder, 88.89g of astragalus extract, 66.67g of ginseng extract, 44.44g of Ligustrum lucidum extract, 36.67g of pregelatinized starch, and 18.33g of microcrystalline cellulose.

[0055] The preparation method is as follows:

[0056] The above four traditional Chinese medicine extracts were passed through 80-mesh sieve respectively, added pregelatinized starch and microcrystalline cellulose and mixed for 30 minutes, added an appropriate amount of purified water, stirred to make a suitable soft material, granulated with a 20-mesh sieve, and granulated at 65±5 Dry under normal pressure at ℃, control the water content of the granules below 5.0%, cool naturally to room temperature, sieve the granules with 20 meshes, place the granulated granules and silicon dioxide in a three-dimensional motion mixer, mix for 30 minutes, and mix well Fill it and make 1000 capsules.

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Abstract

The invention relates to a compound ganoderma lucidum spore powder and a preparation method thereof. The compound ganoderma lucidum spore powder comprises raw material medicines and auxiliary materials. The raw material medicines comprise the following components in parts by weight: 1-50 parts of wall-broken ganoderma lucidum spore powder, 1-60 parts of milk-vetch root extract, 1-18 parts of ginseng extract and 1-24 parts of glossy privet fruit extract; and the auxiliary materials comprise pre-gelatinized starch and microcrystalline cellulose. The compound ganoderma lucidum spore powder granules have weak hygroscopicity, short disintegration time limit and good granule fluidity, meet product requirements, and are suitable for continuous filling, production, transportation and storage. In addition, animal function experiments prove that the compound ganoderma lucidum spore powder granules have an obvious function of enhancing the immunity of experimental animals.

Description

technical field [0001] The invention generally relates to the technical field of preparation of health food, in particular to a compound ganoderma lucidum spore powder and a preparation method thereof. Background technique [0002] Health food, by extracting, concentrating, and drying Chinese medicinal materials to make dry extract powder, and then mixing, granulating, extruding, etc. to obtain the required dosage form. [0003] The compound ganoderma lucidum spore powder is composed of broken ganoderma lucidum spore powder, ginseng extract, astragalus extract and Ligustrum lucidum extract. Therefore, the compound ganoderma lucidum spore powder contains a large amount of viscous Chinese medicine extracts or mixed extracts such as polysaccharides, and the prepared particles have strong hygroscopicity, low critical relative humidity, are easy to stick into agglomerates, have poor fluidity, and poor production operability. Contents of the invention [0004] The purpose of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L31/00A23L33/105A23P10/30
CPCA23V2002/00A23L31/00A23L33/105A23P10/30A23V2200/324A23V2250/21A23V2250/51084A23V2250/5118A23V2250/1628
Inventor 肖伟张海弢李曼曼付娟杨晓筱范业文柏伟荣吴云王振中
Owner JIANGSU KANION PHARMA CO LTD
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