A kind of Ganoderma lucidum polysaccharide granule and its preparation method and application

A technology of Ganoderma lucidum polysaccharides and granules, which is applied in applications, polysaccharide/gum-containing food ingredients, pharmaceutical formulations, etc., can solve the problems of unfavorable formation of Ganoderma polysaccharide storage preparations, poor hygroscopicity and fluidity of granules, and unfavorable storage preparations. Good fluidity and dispersibility, high yield and drug loading, and weak hygroscopicity

Active Publication Date: 2021-08-10
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ganoderma lucidum polysaccharide is obtained from the solution obtained by water extraction of Ganoderma lucidum, and is prepared by spray drying, vacuum drying, belt drying or freeze drying. Block, poor fluidity and other shortcomings, not conducive to storage and subsequent formulation molding
[0004] At present, Ganoderma lucidum polysaccharide is mainly used in the preparation of tablets and capsules by wet granulation. During the wet granulation process, the humidity of the granulation environment and the water content of the raw material of Ganoderma lucidum polysaccharide must be strictly controlled. At the same time, a large amount of fillers must be added. As a result, the drug loading capacity of Ganoderma lucidum polysaccharide is low, and the prepared particles have poor hygroscopicity and fluidity, and the molding rate is also low, and the particle size is different, which is not conducive to the storage of Ganoderma lucidum polysaccharide and subsequent formulation molding

Method used

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  • A kind of Ganoderma lucidum polysaccharide granule and its preparation method and application
  • A kind of Ganoderma lucidum polysaccharide granule and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: Preparation of Ganoderma lucidum polysaccharide

[0028] Ganoderma lucidum is subjected to water extraction or water extraction and alcohol precipitation (water temperature 100°C, time 90min, solid-liquid ratio 1:20, extraction twice) and then spray drying or belt drying (spray conditions: inlet air temperature 120°C, atomization pressure 0.2 MPa, outlet temperature 75-80°C), and crushed and passed through a 60-100 mesh sieve to obtain Ganoderma lucidum polysaccharide.

Embodiment 2

[0029] Embodiment 2: Preparation of Ganoderma lucidum polysaccharide particles of the present invention

[0030] Take 20 parts of Ganoderma lucidum polysaccharide and 20 parts of sodium starch phosphate, mix them evenly, and put them into a fluidized bed granulator. The temperature is 60°C, the material temperature is 50°C, the liquid supply speed is 10rpm, the fan frequency is 15Hz, 30 minutes after the end of liquid supply, 28 parts of 2% gum arabic aqueous solution is added, and the coating conditions are set as: inlet air temperature The temperature is 50°C, the material temperature is 45°C, the liquid supply speed is 8rpm, and the fan frequency is 15Hz. Carry out sizing with a 20-80 mesh sieve, and the yield is 74.43%.

[0031] Determination of hygroscopicity: Weigh 1 g of the prepared particles, spread them in a weighing bottle, and accurately weigh the mass of the original sample. Place the weighing bottle open in a constant temperature and humidity chamber under the ...

Embodiment 3

[0038] Embodiment 3: Preparation of Ganoderma lucidum polysaccharide particles of the present invention

[0039] Take 10 parts of Ganoderma lucidum polysaccharide, 6 parts of chitosan hydrochloride, and 10 parts of sodium starch phosphate, and put them into a fluidized bed granulator after mixing evenly. The granulation conditions are set as follows: air inlet temperature is 60°C, material temperature is 50°C, liquid supply speed: 10rpm, fan frequency is 15Hz, 22.75 parts of 2% gum arabic aqueous solution with mass percentage concentration is added after 30 minutes after the liquid supply, and coated The conditions are set as follows: the inlet air temperature is 50°C, the material temperature is 45°C, the liquid supply speed is 8rpm, and the fan frequency is 15Hz. Carry out granulation with 20-80 mesh sieves, and the yield is 75.52%. According to the measurement method of Example 2, the moisture absorption rate in 24 hours was 6.37%, the critical relative humidity in 24 hour...

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Abstract

The invention relates to the technical field of food and medicine, and discloses a ganoderma lucidum polysaccharide granule, a preparation method and application thereof. The Ganoderma lucidum polysaccharide granules of the present invention are granulated from Ganoderma lucidum polysaccharide raw materials, binders, auxiliary materials and gum arabic aqueous solution through fluidized bed granulation, and the auxiliary materials are selected from chitosan hydrochloride, sodium starch phosphate and anhydrous hydrogen phosphate One or more of calcium. In the present invention, by selecting a suitable combination of auxiliary materials and the ratio of raw and auxiliary materials, combined with a suitable fluidized bed granulation process, the prepared Ganoderma lucidum polysaccharide particles have weak hygroscopicity, good fluidity and dispersibility, and high yield and drug loading. The storage and subsequent preparation of polysaccharides provide good application prospects. Moreover, the method has low requirements on equipment, simple process, short production cycle, greatly reduces production cost, improves production efficiency, and is suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of food and medicine, in particular to a ganoderma polysaccharide granule and a preparation method and application thereof. Background technique [0002] Ganoderma lucidum polysaccharide is one of the most effective components in Ganoderma lucidum. It has anti-oxidation, hypoglycemic, hypolipidemic, immune regulation, anti-tumor, radiation protection and other pharmacological activities. It has broad application prospects in health food and drug development. [0003] Ganoderma lucidum polysaccharide is obtained from the solution obtained by water extraction of Ganoderma lucidum, and is prepared by spray drying, vacuum drying, belt drying or freeze drying. Bulk, poor fluidity and other shortcomings are not conducive to storage and subsequent formulation molding. [0004] At present, Ganoderma lucidum polysaccharide is mainly used in the preparation of tablets and capsules by wet granulation. During the wet g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K47/36A61K47/02A61K31/715A61P39/06A61P3/10A61P3/06A61P37/02A61P35/00A61P39/00A23L33/125A23P10/30A23L29/25A23L29/30A23L29/00
CPCA23V2002/00A61K9/1611A61K9/1652A61K9/1682A61K31/715A23L29/015A23L29/25A23L29/30A23L33/125A23P10/30A61P3/06A61P3/10A61P35/00A61P37/02A61P39/00A61P39/06A23V2250/51A23V2250/5022
Inventor 肖俊勇马方励范罗嫡胡明华
Owner INFINITUS (CHINA) CO LTD
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