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Application of 3-acetamidocoumarin in preparation of drugs for treating or preventing hyperuricemia and renal injury

A technology of hyperuricemia and acetamido, applied in drug combination, urinary system diseases, active ingredients of heterocyclic compounds, etc., can solve the problems of severe allergic reaction to the kidney, liver toxicity, damage, etc. Effects of decreased uric acid levels, increased blood uric acid levels

Active Publication Date: 2019-03-15
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these first-line uric acid-lowering drugs have certain side effects. Allopurinol can cause severe allergic reactions and kidney damage, while benzbromarone has liver toxicity.

Method used

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  • Application of 3-acetamidocoumarin in preparation of drugs for treating or preventing hyperuricemia and renal injury
  • Application of 3-acetamidocoumarin in preparation of drugs for treating or preventing hyperuricemia and renal injury
  • Application of 3-acetamidocoumarin in preparation of drugs for treating or preventing hyperuricemia and renal injury

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Embodiment 1

[0025] Experiments were carried out on the protective effect of drugs prepared from 3-acetamidocoumarin on hyperuricemia and the resulting kidney damage, wherein the animals were divided into groups: 30 male ICR mice, 18-22g, 6 in each group, divided into Sham in the control group, Sham-3A in the blank administration group, Model in the model group, and 3A in the administration group. At the same time, the administration group 3A was subdivided into 3A-HD and 3A-MD according to the administration of 3-acetylaminocoumarin , 3A-LD, the doses were 50mg / Kg / d, 10mg / Kg / d, 2mg / Kg / d for experiments.

[0026] The method of administration was intragastric administration, administered once a day, for three consecutive weeks, and started modeling after one week of administration. The model was made by intraperitoneal injection, oxonate potassium and hypoxanthine were given 300 mg / kg each, and the control group was given solvent saline. After the last administration, the eyeballs were rem...

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Abstract

The invention provides an application of 3-acetamidocoumarin in preparation of drugs for treating or preventing hyperuricemia and renal injury and provides an application of 3-acetamidocoumarin in preparation of drugs for treating or preventing renal injury. Hyperuricemia of mouse is induced by oteracil potassium and hypoxanthine, 5-100 mg / kg / d of 3-acetamidocoumarin is taken orally, and mouse ina model group have obviously increased blood uric acid level and significant renal injury; mouse in an administration group have obviously reduced blood uric acid level and have significant renal protection effects.

Description

technical field [0001] The invention belongs to the field of medicines, and particularly relates to the application of 3-acetylaminocoumarin in the preparation of medicines for treating or preventing hyperuricemia and hyperuric acid kidney damage. Background technique [0002] With the improvement of people's living standards, the intake of high-purine foods increases, and purine metabolism is prone to disorder, which can easily increase blood uric acid and cause hyperuricemia (hyperuricemia). According to the report of the China Chronic Kidney Disease Epidemiological Survey Collaborative Group, the prevalence rate of hyperuricemia in Chinese adults was 8.4% from 2009 to 2010. Based on this, it is estimated that there are nearly 93 million hyperuricemia among Chinese people over the age of 18 disease patients, has reached the level of Western developed countries. Hyperuricemia is not only closely related to the pathogenesis of gout, but also closely related to obesity, hype...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P19/06A61P13/12
CPCA61K31/37A61P13/12A61P19/06
Inventor 周虹谢正伟杨宝学王一鸣王亮李海涛
Owner PEKING UNIV