Unlock instant, AI-driven research and patent intelligence for your innovation.

Eye drops, preparation method and application thereof

A technology of eye drops and regulators, applied in the field of ophthalmic preparations, can solve problems such as increased incidence of adverse reactions, poor patient compliance, and redness and swelling in patients' eyes, so as to reduce eye secretions, reduce side effects, and improve experience Sensitive effect

Active Publication Date: 2019-03-19
湖北远大天天明制药有限公司
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, benzalatelysine is highly irritating to the eyes, which can easily lead to redness and swelling in the eyes of patients, increased secretions, and an increase in the incidence of adverse reactions, which makes the patient's compliance poor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Eye drops, preparation method and application thereof
  • Eye drops, preparation method and application thereof
  • Eye drops, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] Further, the embodiment of the present invention also provides a preparation method of eye drops, comprising the following steps:

[0025] First, the dosage of each substance is calculated according to the formula, and then the raw material of the pH regulator is mixed with water for injection to obtain a pH regulator solution.

[0026] Mix Bendazyl lysine and solubilizer with an appropriate amount of water for injection to obtain the first mixed solution. First, mix and dissolve Bendax lysine and solubilizer, which can improve the solubility of raw materials, and then increase the active ingredients in eye drops ground content.

[0027] Taurine is mixed and dissolved with an appropriate amount of water for injection to ensure that each material can be mixed evenly, and that taurine can be fully mixed with benzyl lysine to ensure the synergistic effect of the two.

[0028] Add an appropriate amount of injection water into the reactor and raise the temperature to 90-100...

Embodiment 1

[0033] The present embodiment provides a kind of eye drop (1000mL), and it comprises 0.05g bendalysine, 3g taurine, 0.05gpH regulator, 1.0g sodium chloride, 0.05g Tween 80, 0.1g hypromell base cellulose, and the balance is water. Wherein, the pH regulator is a mixture of sodium dihydrogen phosphate and disodium hydrogen phosphate.

[0034] Present embodiment also provides a kind of preparation method of eye drops:

[0035] Dissolving sodium dihydrogen phosphate and disodium hydrogen phosphate in water for injection to obtain a pH regulator solution;

[0036] Dissolving Tween 80 and Bendalysine in water for injection to obtain the first mixed solution;

[0037] Taurine is dissolved in water for injection to obtain a taurine solution;

[0038] Add an appropriate amount of water for injection into the reactor and raise the temperature to 90°C, then mix with hydroxypropylmethylcellulose, pH regulator solution, osmotic pressure regulator, first mixed solution and taurine solutio...

Embodiment 2-6

[0040] The eye drops provided by embodiment 2-6 are the same as the eye drops raw materials provided by embodiment 1, the difference is that the specific dosage is different; the preparation method of the eye drops provided by embodiment 2-6 is the same as that of the eye drops provided by embodiment 1 The preparation methods are basically the same, the difference is that the operating conditions are different.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of eye preparations, in particular to eye drops, a preparation method and an application thereof. Every 1000 ml eye drops contains 0.05-0.1 g of bendazac lysine, 3-7g of taurine, 0.05-0.1 g of a pH regulator, 1.0-3.0 g of an osmotic pressure regulator, 0.05-0.15 g of a solubilizer and 0.1-0.3 g of a tackifier. By using the taurine and bendazac lysine in a combined manner for synergistic interaction, the treatment effect of cataract is enhanced, and meanwhile, the taurine and bendazac lysine are combined in use to reduce the side effects of the eye drops, andthe eye secreta after applying the eye drops is reduced. Meanwhile, the generating probability of red and swollen, edema and the like is reduced obviously, and the pharmacy experience of a patient isimproved.

Description

technical field [0001] The invention relates to the field of ophthalmic preparations, in particular to an eye drop, its preparation method and application. Background technique [0002] Benda Lysine Eye Drops is an aldose reductase inhibitor. Aldose reductase can promote the reduction of glucose and galactose in the human lens into alcohols that are difficult to penetrate into the cell membrane, and absorb water outside the cell membrane into the lens, making the lens protein fibers Swelling, disorganization, and changes in light transmission form cataracts. Bendalysine eye drops can enter the eye tissue and aqueous humor through local eye drops, and gather in the lens, effectively inhibit the activity of aldose reductase in the eye, delay the development of cataract, and achieve the goal of preventing or treating cataract Purpose. However, benzalatelysine is highly irritating to the eyes, which can easily lead to redness and swelling in the eyes of patients, increased sec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/416A61K31/185A61P27/12
CPCA61K9/0048A61K31/185A61K31/416A61P27/12A61K2300/00
Inventor 付欢王超尹传忠万利鹏延静
Owner 湖北远大天天明制药有限公司