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Pingyangmycin local injection preparation and preparation method thereof

A technology of local injection and pingyangmycin, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and drug delivery. effect, low viscosity

Active Publication Date: 2019-03-22
WUHAN CONFORM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ordinary injections are easy to spread throughout the body and cannot provide long-term treatment for the lesion.

Method used

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  • Pingyangmycin local injection preparation and preparation method thereof
  • Pingyangmycin local injection preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] A local injection preparation of pingyangmycin, comprising 0.05g of pingyangmycin hydrochloride, 2ml of absolute ethanol, 15g of soybean lecithin, 20g of glyceryl dioleate and 2g of poloxamer 407. The preparation method is as follows: first mix 0.05g of pingyangmycin hydrochloride with 2ml of absolute ethanol to form a suspension, then mix it with 15g of soybean lecithin, 20g of glyceryl dioleate and 2g of poloxamer 407, and keep stirring for 2h , and finally sterilized by filtration to obtain Pingyangmycin local injection preparation A1.

Embodiment 2

[0024] A local injection preparation of pingyangmycin, comprising 0.08g of pingyangmycin hydrochloride, 4ml of absolute ethanol, 20g of soybean lecithin, 25g of glyceryl dioleate and 2g of polyethylene glycol 200. The preparation method is as follows: first mix 0.08g of pingyangmycin hydrochloride with 4ml of absolute ethanol to form a suspension, then mix it with 20g of soybean lecithin, 25g of glyceryl dioleate and 2g of polyethylene glycol 200, and keep stirring for 3h , and finally sterilized by filtration to obtain Pingyangmycin local injection preparation A2.

Embodiment 3

[0026] A pingyangmycin local injection preparation, comprising 0.06g pingyangmycin hydrochloride, 3ml absolute ethanol, 20g egg yolk lecithin, 30g triolein and 3g poloxamer 407. The preparation method is as follows: mix 0.06g pingyangmycin hydrochloride, 20g egg yolk lecithin, 30g triolein and 3g poloxamer 407, keep stirring for 4 hours, and finally filter and sterilize to obtain pingyangmycin local injection preparation A3 .

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PUM

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Abstract

The invention discloses a pingyangmycin local injection preparation and a preparation method thereof. The pingyangmycin local injection preparation comprises 0.05 to 0.1g of pingyangmycin hydrochloride, 2 to 5ml of ethanol, 15 to 25g of phospholipid, 20 to 30g of glyceride, and 2 to 3g of a stabilizer. The pingyangmycin hydrochloride, ethanol, phospholipid, glyceride and stabilizer are uniformly mixed, so as to form the pingyangmycin local injection preparation. The pingyangmycin local injection preparation is used for treating deep hemangioma severe in lesion and positioned below skin, has along-acting slow-release effect, and is good in compatibility and easy to metabolize in body.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to a pingyangmycin local injection preparation and a preparation method thereof. Background technique [0002] Hemangioma (hemangioma) is a congenital benign tumor or hemangioma formed by the proliferation of hemangioblasts during embryonic period, which is commonly found in the skin and soft tissue, and is more common in infants at or shortly after birth. Residual embryonic hemangioblasts and active endothelial-like germs invade adjacent tissues, forming endothelial-like cords, which are connected with the remaining blood vessels to form hemangiomas after canalization. The blood vessels in the tumor form a self-contained system without connecting with surrounding blood vessels. Hemangiomas can occur anywhere in the body, most of which occur in the facial skin, subcutaneous tissue, and oral mucosa, such as tongue, lips, and floor of the mouth, and a few occur in the jawbone or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/24A61K47/14A61K38/14A61P35/00
CPCA61K38/14A61K47/14A61K47/24A61P35/00A61K9/0024
Inventor 蔡育周小顺牟东升刘文双李进贺容丽
Owner WUHAN CONFORM PHARMA CO LTD