Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof
A technology of polyethylene glycol methacrylate and polydopamine, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as disulfide bond cleavage, and achieve control The effect of drug release, increasing drug loading, and improving biocompatibility
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[0037] Example 1
[0038] according to figure 1 The shown synthetic route prepares dual-response hollow mesoporous silicon coated polydopamine grafted polyethylene glycol methacrylate drug-loaded microspheres, the specific method is as follows:
[0039] 1. Preparation of hollow mesoporous silicon drug-loaded nanospheres
[0040] Dissolve 50mg of doxorubicin hydrochloride (DOX) in 30mL pH=7.4 PBS buffer, and then add 100mg hollow mesoporous silicon nanospheres (HMSN, according to the literature "XL Fang, C Chen, ZH Liu, PX Liu, NF Zheng. Acationic surfactant assisted selective etching strategy to hollow mesoporoussilica spheres. Prepared by the method disclosed in Nanoscale, 2011, 3:1632-1639. Its BET surface area, BJH pore volume and BJH pore diameter are 1183.28m, respectively 2 / g, 1.26cm 3 / g and 3.95nm), stirred at room temperature for 24h, centrifuged, the resulting solid product was washed with deionized water until the centrifugal liquid was basically colorless, collected the ...
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