Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof

A technology of polyethylene glycol methacrylate and polydopamine, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as disulfide bond cleavage, and achieve control The effect of drug release, increasing drug loading, and improving biocompatibility

Active Publication Date: 2019-03-29
SHAANXI NORMAL UNIV
View PDF6 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disulfide bond is a commonly used covalent bond, which can exist stably in the process of blood circulation in the body, but the disulfide bond will be broken under a certain concentration of reduced glutathione

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof
  • Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof
  • Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] according to figure 1 The synthetic route shown prepares double-response hollow mesoporous silicon-coated polydopamine-grafted polyethylene glycol methacrylate drug-loaded microspheres, and the specific method is as follows:

[0039] 1. Preparation of hollow mesoporous silicon drug-loaded nanospheres

[0040] Dissolve 50 mg of doxorubicin hydrochloride (DOX) in 30 mL of PBS buffer at pH = 7.4, and then add 100 mg of hollow mesoporous silicon nanospheres (HMSN, according to the literature "X L Fang, C Chen, Z H Liu, P X Liu, N F Zheng. Acationic surfant assisted selective etching strategy to hollow mesoporoussilica spheres. Nanoscale, 2011, 3:1632-1639" prepared by the method disclosed, its BET surface area, BJH pore volume and BJH pore diameter were 1183.28m 2 / g, 1.26cm 3 / g and 3.95nm), stirred at room temperature for 24h, and centrifuged, the obtained solid product was washed with deionized water until the centrifuge was basically colorless, the solid was collected...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and a preparation method thereof. The preparation method comprises the following steps of coating the rear surface physically adsorbing organic micromolecule medicines, of hollow mesoporous silicon nanometer microspheres, with polydopamine, then introducing disulfide bonds and aminos through an esterification reaction, performing surface acylation and bromination, performing grafting with poly(ethylene glycol) methyl ether methacrylate, and finally performing secondary physical adsorption of organic micromolecule medicines so as to obtain the hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methylether methacrylate medicine loading microspheres. According to the dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loadingmicrospheres disclosed by the invention, hollow mesoporous silicon can effectively perform medicine loading, the polydopamine coated hollow mesoporous silicon has unique pH and glutathione responsiveness, and the grafted polyethylene glycol can improve the biocompatibility and the water solubility of the nanometer microspheres. Under different lesion cell environment, medicines can effectively, synergistically and slowly release from mesoporous layers and polymer layers according to physiology environment changes, and the purpose of target treatment can be achieved.

Description

technical field [0001] The invention belongs to the technical field of material synthesis and biomedicine, and specifically relates to a hollow mesoporous silicon-coated polydopamine-grafted polyethylene glycol methacrylate drug-loaded nano-microsphere with dual responses and a preparation method thereof. Background technique [0002] Traditionally, intravenous drugs are used to treat cancer, which usually has disadvantages such as low treatment efficiency and toxic side effects. Localized and controlled drug release systems can effectively increase the efficiency of cancer therapy and reduce the harm of toxic chemical components and radiation therapy to healthy cells. Therefore, this controlled drug release system has received extensive attention in the field of cancer therapy. Among them, mesoporous silicon nanospheres have attracted extensive attention due to their unique physical and chemical properties, including large surface area, pore volume, uniform pore size, high...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/58A61K9/51A61K47/04A61K47/34A61K31/704A61P35/00
CPCA61K9/5115A61K9/5146A61K9/5153A61K9/5192A61K31/704A61P35/00
Inventor 罗延龄张瑞乾徐峰陈亚芍
Owner SHAANXI NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com