Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof

A technology of polyethylene glycol methacrylate and polydopamine, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as disulfide bond cleavage, and achieve control The effect of drug release, increasing drug loading, and improving biocompatibility

Active Publication Date: 2019-03-29
SHAANXI NORMAL UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Disulfide bond is a commonly used covalent bond, which can exist stably in the process of blood circulati

Method used

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  • Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof
  • Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof
  • Dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and preparation method thereof

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[0037] Example 1

[0038] according to figure 1 The shown synthetic route prepares dual-response hollow mesoporous silicon coated polydopamine grafted polyethylene glycol methacrylate drug-loaded microspheres, the specific method is as follows:

[0039] 1. Preparation of hollow mesoporous silicon drug-loaded nanospheres

[0040] Dissolve 50mg of doxorubicin hydrochloride (DOX) in 30mL pH=7.4 PBS buffer, and then add 100mg hollow mesoporous silicon nanospheres (HMSN, according to the literature "XL Fang, C Chen, ZH Liu, PX Liu, NF Zheng. Acationic surfactant assisted selective etching strategy to hollow mesoporoussilica spheres. Prepared by the method disclosed in Nanoscale, 2011, 3:1632-1639. Its BET surface area, BJH pore volume and BJH pore diameter are 1183.28m, respectively 2 / g, 1.26cm 3 / g and 3.95nm), stirred at room temperature for 24h, centrifuged, the resulting solid product was washed with deionized water until the centrifugal liquid was basically colorless, collected the ...

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Abstract

The invention discloses dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loaded microspheres and a preparation method thereof. The preparation method comprises the following steps of coating the rear surface physically adsorbing organic micromolecule medicines, of hollow mesoporous silicon nanometer microspheres, with polydopamine, then introducing disulfide bonds and aminos through an esterification reaction, performing surface acylation and bromination, performing grafting with poly(ethylene glycol) methyl ether methacrylate, and finally performing secondary physical adsorption of organic micromolecule medicines so as to obtain the hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methylether methacrylate medicine loading microspheres. According to the dual-response hollow mesoporous silicon coated polydopamine grafted poly(ethylene glycol) methyl ether methacrylate medicine loadingmicrospheres disclosed by the invention, hollow mesoporous silicon can effectively perform medicine loading, the polydopamine coated hollow mesoporous silicon has unique pH and glutathione responsiveness, and the grafted polyethylene glycol can improve the biocompatibility and the water solubility of the nanometer microspheres. Under different lesion cell environment, medicines can effectively, synergistically and slowly release from mesoporous layers and polymer layers according to physiology environment changes, and the purpose of target treatment can be achieved.

Description

technical field [0001] The invention belongs to the technical field of material synthesis and biomedicine, and specifically relates to a hollow mesoporous silicon-coated polydopamine-grafted polyethylene glycol methacrylate drug-loaded nano-microsphere with dual responses and a preparation method thereof. Background technique [0002] Traditionally, intravenous drugs are used to treat cancer, which usually has disadvantages such as low treatment efficiency and toxic side effects. Localized and controlled drug release systems can effectively increase the efficiency of cancer therapy and reduce the harm of toxic chemical components and radiation therapy to healthy cells. Therefore, this controlled drug release system has received extensive attention in the field of cancer therapy. Among them, mesoporous silicon nanospheres have attracted extensive attention due to their unique physical and chemical properties, including large surface area, pore volume, uniform pore size, high...

Claims

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Application Information

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IPC IPC(8): A61K9/58A61K9/51A61K47/04A61K47/34A61K31/704A61P35/00
CPCA61K9/5115A61K9/5146A61K9/5153A61K9/5192A61K31/704A61P35/00
Inventor 罗延龄张瑞乾徐峰陈亚芍
Owner SHAANXI NORMAL UNIV
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