Rapid and batch forming apparatus of paper-based microfluidic chips

Abstract

The invention discloses a rapid and batch forming apparatus of paper-based microfluidic chips. A hydrophilic paper tape in a width of 20 to 200 mm is arranged on a fixed shaft A in a coiling manner, awax-based carbon tape in the same width with the filter paper is arranged on a fixed shaft B, the carbon tape and the paper tape are stacked and then pass through a hot pressing roller together underthe action of a traction roller, a structure on the hot pressing roller is transferred from the wax-based carbon tape to the filter paper tape under the action of pressure and high temperature, the waste wax-based carbon tape is transferred to a fixed shaft C to be recycled, the filter paper is further transported to a heating roller to be heated, and wax on the filter paper penetrates into gapsof paper fibers after being heated and melted; then the paper tape passes through a cooling roller, and the cooled wax is solidified on a paper substrate to form a hydrophobic flow passage boundary, and the fluid moves in hydrophilic paper fibers surrounded by the hydrophobic boundary by virtue of the capillary action, thereby realizing the functions for analyzing and detecting the microfluidic chips and the like. By adopting the rapid and batch forming apparatus of the paper-based microfluidic chips, the application and industrial development of the paper-based microfluidic chips are promoted, and a wide application value in the fields of rapid detection and on-site detection can be achieved.

Description

technical field [0001] The invention relates to a rapid and batch forming device for a paper-based microfluidic chip, in particular to a processing device for a paper-based microfluidic chip that uses wax to construct a closed flow channel. Background technique [0002] Paper-based microfluidic chips are referred to as paper chips. In 2007, Martinez et al. first proposed to use paper as the base material to make microfluidic chips. Compared with traditional microfluidic chips, paper chips are cheaper and easier to process. Easier to carry. At present, the processing methods of paper-based microfluidic chips mainly include wax printing method, ultraviolet lithography method, plasma treatment technology, inkjet printing technology, melting wax soaking technology and other methods. Cai Longfei et al. proposed a technology for inkjet printing of surfactants, printing the printing liquid Trition X-100 onto the filter paper treated with octadecyltrimethoxysilane, so that the prin...

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Problems solved by technology

[0005] The above methods of preparing paper-based microfluidic chips have their own advantages and disadvantages. The wax printing method is easy to process, but it may lead to irregular shapes of the hydrophilic region and cannot guarantee the accuracy of the sample flow channel; plasma treatment technology can complete the processing process at one time , but every time the shape of the flow channel is changed, a metal mold of a specific shape needs to be made, which increases the processing cost and complicates the processing process; the preparation method of melting wax impregnation does not require complicated instruments and any organic solvents, but the accuracy is not high

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