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A stabilizer composition

A stabilizer and composition technology, applied in the field of clinical testing and biochemistry, can solve the problems of high blank absorbance of reagents and no stability of reagents provided

Active Publication Date: 2021-05-18
BEIJING STRONG BIOTECH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, CN1197974C does not provide evidence of reagent stability, and the reagent blank absorbance is higher

Method used

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  • A stabilizer composition
  • A stabilizer composition
  • A stabilizer composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation of stabilizer composition

[0046] 1. After fully dissolving and mixing the following components, a stabilizer composition 1 can be obtained:

[0047] 80g / L glucose,

[0048] 300g / L glycerin,

[0049] 5g / L Thesit.

[0050] 2. After fully dissolving and mixing the following components, a stabilizer composition 2 can be obtained:

[0051] 120g / L glucose,

[0052] 250g / L glycerin,

[0053] 6g / L Thesit.

Embodiment 2

[0054] Embodiment 2: the preparation of comparison kit

[0055] 1. The first reagent comprises:

[0056] 10.57g / L Diglyceride, 2.92g / L Sodium Chloride and 1g / L Sodium Azide.

[0057] 2. The second reagent comprises:

[0058] 2.90g / L glycylprolyl-p-nitroaniline p-toluenesulfonate and 1g / L Proclin 300.

[0059] 3. Assemble the first reagent and the second reagent into a kit.

Embodiment 3

[0060] Embodiment 3. Preparation of the application kit

[0061] 1. The kit 1 was prepared according to the method of Example 2, except that the second reagent also contained 30% (v / v) of the stabilizer composition 1 obtained in Example 1.

[0062] 2. The kit 2 was prepared according to the method of Example 2, except that the second reagent also contained 30% (v / v) of the stabilizer composition 2 obtained in Example 1.

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Abstract

The present application relates to a stabilizer composition. The stabilizer composition comprises 40g / L to 200g / L glucose, 50g / L to 350g / L glycerin and 2g / L to 8g / L polidocanol Thesit. After the stabilizer composition of the present application is added to the glycylproline dipeptide aminopeptidase assay reagent, it can significantly improve the stability of the substrate and effectively extend the life of the glycylproline dipeptide aminopeptidase assay kit. save time.

Description

technical field [0001] This application relates to the fields of clinical testing and biochemistry. More specifically, it relates to a stabilizer composition, which is specially used for the determination of glycylproline dipeptide aminopeptidase. Background technique [0002] Glycylproline dipeptide aminopeptidase (GPDA) is a dipeptide hydrolase that can specifically hydrolyze peptide bonds whose N-terminal is glycyl-prolyl. In the human body, GPDA is mainly distributed in liver, kidney, connective tissue, salivary gland, serum, saliva and other body fluids, and most of intracellular GPDA (55%) is distributed in microsomes. [0003] Serum GPDA levels in healthy adults are relatively constant. However, in some pathological conditions, an increase or decrease may occur. Hepatobiliary system diseases such as primary liver cancer, acute hepatitis, chronic active hepatitis, liver cirrhosis and obstructive jaundice and other serum GPDA activity were significantly higher than n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/31
CPCG01N21/31
Inventor 张静茹宋占科蔡华雅刘希
Owner BEIJING STRONG BIOTECH INC