Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A pharmaceutical composition for reducing brain damage caused by cerebral apoplexy using rosmarinic acid

A technology for rosmarinic acid and brain injury, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients. low cost effect

Active Publication Date: 2020-12-01
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, actively seeking new drugs with multiple neuroprotective effects has always been the focus of research and development of drugs for the treatment of ischemic stroke, but so far there is no clinically proven neuroprotective agent with clear efficacy

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A pharmaceutical composition for reducing brain damage caused by cerebral apoplexy using rosmarinic acid
  • A pharmaceutical composition for reducing brain damage caused by cerebral apoplexy using rosmarinic acid
  • A pharmaceutical composition for reducing brain damage caused by cerebral apoplexy using rosmarinic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1 Materials 1.1 Experimental animals Healthy adult ♂, 60 SPF grade SD rats, body weight (280±20) g, purchased from Shanghai Slack Experimental Animal Co., Ltd., certificate number: 2007000509960, license number: SCXK (Shanghai) From 2007 to 0005, he was raised in the SPF level animal laboratory of the Experimental Animal Center of Fujian University of Traditional Chinese Medicine. Maintain constant temperature and humidity for 24 hours, sufficient food and drinking water, simulate natural diurnal changes, give light from 6:00 to 18:00, and be in the dark state from 18:00 to 6:00 the next day, and feed adaptively for a week.

[0024]1.2 Main Reagents and Test Drugs Total RNA Extraction Kit RNeasy® Mini Kit (QIAGEN, Cat. No.: 74106), Reverse Transcription Kit RT Kit (Fermentas, Cat. No.: K1622), Fluorescent Quantitative PCR Master Mix (Applied Biosystems, Cat. No. :R11022), PCR primers were synthesized by Shanghai Jierui Biological Engineering Co., Ltd. TNF-α gene primers...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a pharmaceutical composition for reducing progressive stroke and brain injury by applying rosmarinic acid and belongs to the field of pharmacy. The pharmaceutical composition isprepared from the rosmarinic acid and salidroside, wherein the mass ratio of the rosmarinic acid to the salidroside is 1 to 1. The rosmarinic acid and salidroside combined medicine provided by the invention has more remarkable function characteristics of neuroprotection, inflammatory response inhibition and the like for tMCAO rats than those of single administration and accords with an international new orientation of screening new drugs at current. The rosmarinic acid and salidroside combined medicine provided by the application is used as a novel possible neuroprotective agent and a potential neuroprotective mechanism and provides a new experimental evidence for clinical treatment and application.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a pharmaceutical composition for reducing brain damage caused by cerebral apoplexy by applying rosmarinic acid. Background technique [0002] Stroke, commonly known as cerebral apoplexy, is a sudden-onset cerebral blood circulation disorder and the most serious complication of cerebrovascular diseases. According to my country's third national cause of death survey (2012), the fatality rate of stroke ranks first, as high as 22.45%, and the disability rate is as high as 75%, which brings serious burdens to families and society. [0003] Over the past 30 years, nearly 200 stroke drugs have entered clinical trials around the world. But so far, only tissue-type fibrinolytic agent (tPA) has been approved by the US FDA for clinical application. However, due to the shortcoming that tPA can only be used for patients with cerebral thrombosis and its treatment "time window" is narrow (...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7032A61K31/216A61P9/10
CPCA61K31/216A61K31/7032A61P9/10A61K2300/00
Inventor 魏艺聪卢伟车苏容
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com