Composition with repairing and anti-aging effects, and preparation method and application thereof
A composition and anti-aging technology, which is applied in skin care preparations, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of limited skin absorption effect and unsatisfactory anti-aging effect, and achieve a reasonable and easy-to-absorb formula Effect
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Embodiment 1
[0059] This embodiment provides a composition (I) with repairing and anti-aging effects, which includes the following components by weight percentage:
[0060]
[0061]
[0062] Its preparation method comprises the following steps:
[0063] (1) Ultrasonic mixing of soybean lecithin, cholesterol and ethanol to obtain ethanol solution A; after ultrasonic mixing of squalane, ubiquinone, ceramide 3, ceramide 6II, cypress essential oil and ethanol, use 0.22 μm organic Filter through a microporous membrane to obtain ethanol solution B;
[0064] (2) Mix ethanol solution A and ethanol solution B into a syringe, drop them into a phosphate buffer with a pH value of 7.4 at a constant speed of 0.25mL / s at 50°C, and give magnetic stirring at the same time. 200r / min;
[0065] (3) Ethanol was evaporated under reduced pressure at 35°C; the product was incubated at 50°C for 2h, then ultrasonically pulverized in an ice bath for 10min, passed through a 0.45μm microporous filter membrane,...
Embodiment 2
[0068] This embodiment provides a composition (II) with repairing and anti-aging effects, which includes the following components by weight percentage:
[0069] components
weight percentage
Deionized water
margin
1,2-pentanediol
5.0
1,3-Propanediol
15.0
1,2-Hexanediol
2.0
Polyacrylate Crosspolymer-6
0.5
8.0
ubiquinone
2.00
10.0
3.0
Ceramide 3
1.0
0.25
1.0
Sodium hyaluronate (large: medium: small = 1:2:15)
0.25
[0070] Its preparation method comprises the following steps:
[0071] (1) Ultrasonic mixing of soybean lecithin, cholesterol, and ethanol to obtain ethanol solution A; after ultrasonic mixing of squalane, ubiquinone, ceramide 3, cypress essential oil, and ethanol, use a 0.22 μm organic microporous filter membrane Filter to obtain ethanol solution B;
[0072...
Embodiment 3
[0076] This embodiment provides a composition (III) with repairing and anti-aging effects, which includes the following components by weight percentage:
[0077]
[0078]
[0079] Its preparation method comprises the following steps:
[0080] (1) Ethanol phospholipids, cholesterol and ethanol were mixed ultrasonically to obtain ethanol solution A; squalane, ubiquinone, ceramide 1A, ceramide 2, ceramide 3, ceramide 4, cypress essential oil and ethanol were ultrasonically After mixing, filter with a 0.22 μm organic microporous membrane to obtain ethanol solution B;
[0081] (2) Mix ethanol solution A and ethanol solution B into a syringe, drop them into a phosphate buffer with a pH value of 7.4 at a constant speed of 0.24mL / s at 50°C, and give magnetic stirring at the same time. 200r / min;
[0082](3) Ethanol was evaporated under reduced pressure at 35°C; the product was incubated at 40°C for 1.5h, then ultrasonically pulverized in an ice bath for 10min, passed through a ...
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