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A method for studying the oral release of tobacco-specific nitrosamines from oral smokeless tobacco products

A smokeless tobacco and oral-use technology, which is applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of unclear release and absorption of TSNAs, avoid the influence of subjective and objective factors, avoid ethical and moral constraints, Controllable Effects

Active Publication Date: 2022-04-01
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the oral release of tobacco-specific nitrosamines in oral smokeless tobacco products, and the release and absorption of TSNAs by consumers when using such products is still unclear

Method used

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  • A method for studying the oral release of tobacco-specific nitrosamines from oral smokeless tobacco products
  • A method for studying the oral release of tobacco-specific nitrosamines from oral smokeless tobacco products
  • A method for studying the oral release of tobacco-specific nitrosamines from oral smokeless tobacco products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] A method for studying the oral release of nitrosamines specific to oral smokeless tobacco products, comprising the steps of:

[0069] Step (1), screening of oral smokeless tobacco products: select 100 pieces of a certain oral smokeless tobacco product to be studied for weight detection, and calculate the average weight and variance of the single weight of the product; after that, select Products whose weight range is within the range of the average value ± 3 times the variance are used as samples for subsequent determination;

[0070] Step (2), determination of simulated dissolution parameters: select multiple healthy volunteers to suck the samples screened in step (1) in a natural state, and collect residual samples and saliva of each volunteer at a predetermined time point, Use one sample per time point;

[0071] Step (3), determination of the oral release of tobacco-specific nitrosamines in vivo: use liquid chromatography mass spectrometry to test the oral smokeless...

Embodiment 2

[0078] A method for studying the oral release of nitrosamines specific to oral smokeless tobacco products, comprising the steps of:

[0079] Step (1), screening of oral smokeless tobacco products: select 50 pieces of a certain oral smokeless tobacco product to be studied for weight detection, and calculate the average weight and variance of the single weight of the product; after that, select Products whose weight range is within the range of the average value ± 1 times the variance shall be used as samples for subsequent determination;

[0080] Step (2), determination of simulated dissolution parameters: select multiple healthy volunteers to suck the samples screened in step (1) in a natural state, and collect residual samples and saliva of each volunteer at a predetermined time point, Use one sample per time point;

[0081] Step (3), determination of the oral release of tobacco-specific nitrosamines in vivo: use liquid chromatography mass spectrometry to test the oral smoke...

Embodiment 3

[0090] A method for studying the oral release of nitrosamines specific to oral smokeless tobacco products, comprising the steps of:

[0091] Step (1), screening of oral smokeless tobacco products: select 150 pieces of a certain oral smokeless tobacco product to be studied for weight detection, and calculate the average weight and variance of the product; after that, select Products whose weight range is within the range of the average value ± 2 times the variance are used as samples for subsequent determination;

[0092] Step (2), determination of simulated dissolution parameters: select multiple healthy volunteers to suck the samples screened in step (1) in a natural state, and collect residual samples and saliva of each volunteer at a predetermined time point, Use one sample per time point;

[0093] Step (3), determination of the oral release of tobacco-specific nitrosamines in vivo: use liquid chromatography mass spectrometry to test the oral smokeless tobacco products to ...

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Abstract

The invention relates to a method for researching the release of nitrosamines in the oral cavity of oral smokeless tobacco products. Determination of oral release of nitrosamines, in vitro test simulation and other steps. The present invention uses in vivo experiments to determine in vitro research parameters, and uses a fully simulated chewing machine to test samples in vitro. The device used can completely simulate the state of human oral cavity smoking smokeless tobacco products. The temperature can be adjusted, and the controllability is strong, the stability is high, and the operation is simple. The research method of the present invention can well avoid the influence of subjective and objective factors brought about by traditional artificial tasting, avoid the ethical and moral restrictions of a large number of people's experiments, save the experiment cost and reduce the health hazards caused by human experiments , suitable for batch studies of samples.

Description

technical field [0001] The invention belongs to the technical field of analysis of oral smokeless tobacco products, and in particular relates to a method for studying the oral release of nitrosamines peculiar to oral smokeless tobacco products. The method can be used to study and analyze oral smokeless tobacco products Tobacco-specific nitrosamine leaching from smoke tobacco products. Background technique [0002] Smokeless Tobacco products (STPs for short) refer to tobacco products that are smoked directly through the mouth or nose without burning. Compared with traditional cigarettes, they have fewer harmful components and are less harmful; at the same time, they do not produce second-hand smoke. To a certain extent, it can alleviate the contradiction between smoking ban and smoking in public places, and satisfy the physiological needs of smokers to a certain extent. [0003] Smokeless tobacco products come in various forms such as snus in pouches, snus and chewing tobacc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 杨继赵杨段沅杏米其利高茜管莹赵辉刘春波申钦鹏杨柳
Owner CHINA TOBACCO YUNNAN IND
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