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Model method for calculating equivalent uniform dosage of radiotherapy

A radiation therapy and dose technology, applied in computer-aided medical procedures, medical simulation, medical informatics, etc.

Pending Publication Date: 2019-05-03
戴立言 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the LQ linear quadratic model widely used in the industry has relatively large defects when it is applied in stereotactic radiation therapy (SBRT).

Method used

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  • Model method for calculating equivalent uniform dosage of radiotherapy
  • Model method for calculating equivalent uniform dosage of radiotherapy
  • Model method for calculating equivalent uniform dosage of radiotherapy

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Embodiment Construction

[0049] The present invention attempts to modify the linear quadratic model on the basis of the electronic secondary killing theory, and fit the function in sections according to the difference in single dose, so that the matching effect between the model and the experimental data is better; at the same time, the average survival rate is used to Based on the principle of equality, a new Equivalent Uniform Dose Model (EUD) is designed to correct the uneven distribution of dose in the target area, to help realize the mutual conversion of single high dose, hypofractionation treatment mode and conventional fractionation mode, and to construct a new biological Dose conversion platform

[0050] The present invention deduces the equivalent uniform dose based on the piecewise quadratic function model. Using this formula, the treatment planning system can quickly obtain the equivalent uniform dose of tumors and normal tissues, which is beneficial to the comparison of radiotherapy schemes...

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Abstract

The invention discloses a model method for calculating an equivalent uniform dosage of radiotherapy, wherein an LQ model is not fundamentally changed and a cell survival condition in a single large dose can be well reflected. Effectiveness of original clinical experience is ensured, and the method can be used for effect evaluation of large dose irradiation after slight correction of the original data. Based on the equivalent uniform dose of a segmented secondary function model, by means of a formula, a treatment planning system can quickly acquire the equivalent uniform doses of a tumor and anormal organization, thereby facilitating comparative evaluation of treatment plans with different dose segmentation modes and different dose distribution patterns. The segmented secondary function model is used for settling a problem of high cell survival rate prediction deviation after performing large-dose irradiation by a traditional linear secondary model. The equivalent uniform dosage modelbased on the model realizes comparison of the treatment effects in different dose distributions. After introducing latent doubling time, the advantages of single large-dose irradiation at an aspect ofovercoming cell proliferation is presented, and a difficulty in clinical application of a radiation biological model is basically solved.

Description

technical field [0001] The invention relates to a model method for calculating equivalent uniform dose of radiotherapy, which belongs to the technical field of radiotherapy. Background technique [0002] Tumor radiotherapy is a treatment method that uses radiation to treat tumors. Like surgery and drug therapy, radiotherapy has become an important treatment method for tumor treatment. The fundamental purpose of radiation therapy is to deliver a high curative dose to the tumor area while the surrounding tissues and organs receive the least dose. It can be understood that an appropriate compromise must be achieved between the dose effects of tumor tissue and normal tissue. [0003] After more than a century of clinical practice, it has been confirmed that fractionated radiation therapy has become the basic principle of effective radiation therapy recognized in the industry. Clinical and biological studies have proved that the number of irradiation fractions and the size of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/50
Inventor 戴立言周云
Owner 戴立言
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