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Hair growing method for reconstructing hair follicles by using stem cells and applications thereof

A technology of stem cells and hair follicle stem cells, applied in the field of hair growth technology and stem cells, can solve the problems of impossible survival of hair follicles, failure to rebuild the physiological conditions of hair follicle stem cells, etc., and achieve the effect of solving the problem of hair loss

Inactive Publication Date: 2019-05-07
华子昂 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For the hair loss caused by hair follicle atrophy and apoptosis, it can only be solved by adjusting the physiological state of the scalp dermis and rebuilding the hair follicles. If the physiological conditions for the growth and differentiation of hair follicle stem cells in the scalp dermis are not rebuilt, no amount of hair follicles will be transplanted. May survive, may not really fix hair loss

Method used

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  • Hair growing method for reconstructing hair follicles by using stem cells and applications thereof
  • Hair growing method for reconstructing hair follicles by using stem cells and applications thereof
  • Hair growing method for reconstructing hair follicles by using stem cells and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Patient No. 1 with hair loss is male, aged 36, and weighs 79kg. Collect photos of the patient's hair for comparison before and after treatment, see image 3 ; Ultrasonic detection of the skin and dermis of the patient's head is used for comparison before and after treatment, see Figure 4; 5g of fresh stool samples from patients with hair loss were collected, and the next-generation sequencing method was used for high-throughput sequencing detection of intestinal flora 16sRNA. The intestinal flora detection method refers to (Hu Haibing et al., 2016), and the results are shown in Table 1. At the same time, 30 mL of peripheral blood was collected from the patient, and the biochemical indicators were tested. The test results are shown in Table 2. Genetic testing was carried out on the alopecia. Quantitative PCR primers are shown in Table 3, and the test results are shown in Table 4. According to a variety of test results, use the big data cloud of life to conduct a compr...

Embodiment 2

[0061] One patient with male hair loss, aged 45 years, weighing 81kg. Collect photos of the patient's hair for comparison before and after treatment, see Image 6 ; Ultrasonic detection of the skin and dermis of the patient's head is used for comparison before and after treatment, see Figure 7 5g was collected from fresh stool samples of alopecia patients, and the intestinal flora 16s RNA high-throughput sequencing was detected by next-generation sequencing method. The intestinal flora detection method refers to (Hu Haibing et al., 2016), and the results are shown in Table 5. At the same time, 30 mL of peripheral blood was collected from the patient for biochemical index detection. The test results are shown in Table 6. Carry out gene detection to alopecia person, quantitative PCR primer is shown in Table 7, and test result is shown in Table 8. According to a variety of test results, use the big data cloud of life to conduct a comprehensive analysis of the body's hormone le...

Embodiment 3

[0086] Patient No. 3 with hair loss, aged 39 years, weighing 128kg. Collect photos of the patient's hair for comparison before and after treatment, see Figure 9 ; Ultrasonic detection of the skin and dermis of the patient's head is used for comparison before and after treatment, see Figure 10 ; Collect 5g of fresh stool samples from alopecia patients, and use the next generation sequencing method to perform high-throughput sequencing detection of intestinal flora 16s RNA. The intestinal flora detection method refers to (Hu Haibing et al., 2016), and the results are shown in Table 9. At the same time, 30 mL of peripheral blood was collected from the patient, and the biochemical indicators were tested. The test results are shown in Table 10. Carry out gene detection to alopecia person, quantitative PCR primer is shown in Table 11, and test result is shown in Table 12. According to a variety of test results, use the big data cloud of life to conduct a comprehensive analysis o...

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Abstract

The invention relates to a hair growing method for reconstructing hair follicles by using stem cells. The method comprises the following steps: S1, aiming at specific physiological indexes of an alopecia patient, inhibiting a hair follicle atrophy apoptosis signal path and regulating up a hair follicle growth and development signal path so as to recover the physiological conditions required by thework of hair follicle stem cells on the scalp dermis layer of the alopecia patient; S2, separating the stem cells of the alopecia patient, optimizing culture conditions, and finishing in vitro amplification culture; and S3, implanting the stem cells which are subjected to in vitro amplification culture into the dermal layer of the scalp of the alopecia patient, regulating and controlling the Wnt / beta-catenin signal path for regeneration of the hair follicle stem cells, and matching various cell factors to enable the hair follicle stem cells and the differentiated cells to reconstruct the hairfollicle structure in a self-organization mode, so that the hair follicle is autonomously formed and grows out hair. The method promotes hair growth by reconstructing local microenvironment of scalpof the alopecia patient and introducing hair follicle stem cells, follows the rule of hair growth, and solves the problem of alopecia.

Description

technical field [0001] The invention relates to the technical field of hair growth and the field of stem cells, in particular to a method of hair growth using hair follicle stem cells to rebuild hair follicles and its application in the field of hair growth. Background technique [0002] Hair loss has a great impact on the overall appearance of people, and it will lead to psychological and physiological problems, and sometimes seriously affect the normal life of the hair loss person. The main factors of hair loss include: genetic factors, pathological factors, physiological hormone disorders, nutritional deficiencies, and other factors. A diet formula conditioning. But the problem of hair loss cannot be effectively solved all the time. The fundamental reason is that we have not followed the inherent law of hair growth and development to solve the problem of hair loss. [0003] The entire development period of hair includes four stages: anagen, catagen, telogen, and neonata...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61K35/28A61K35/51A61K35/545A61P17/14
Inventor 华子昂万君兴竹添孙宁王娇张健范春兰
Owner 华子昂
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