miRNA marker miR-19b associated with bone metabolic diseases and application thereof

A technology of mir-19b and bone metabolism, applied in the direction of DNA/RNA fragments, recombinant DNA technology, microbial measurement/inspection, etc., can solve the problem of inability to absolutely reflect changes in the activity of bone cells and periosteum in bone tissue, and the large biological difference of PINP, etc. to facilitate clinical diagnosis, ensure accuracy, and improve sensitivity and specificity

Inactive Publication Date: 2019-05-07
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the levels of CTXI and PINP are affected by liver and kidney functions, and cannot absolutely reflect the changes in the activity of osteocytes and periosteum in bone tissue, and the biological diversity of PINP is also greater

Method used

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  • miRNA marker miR-19b associated with bone metabolic diseases and application thereof
  • miRNA marker miR-19b associated with bone metabolic diseases and application thereof
  • miRNA marker miR-19b associated with bone metabolic diseases and application thereof

Examples

Experimental program
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Embodiment

[0031] Collection and separation of 1 blood sample

[0032] Blood collection via blood collection tube: Take a blood collection tube and mark the name of the person to be collected on the wall of the blood collection tube (do not loosen the cap of the blood collection tube). Perform local disinfection on the cubital vein of the blood sampler. Take a blood collection needle, pull out the venous needle sheath, and insert the needle into the vein, and blood can be seen flowing into the hose. Insert the blood collection needle on the other side together with the soft sheath into the blood collection tube, and the blood will automatically flow into the blood collection tube. About 5ml of blood was collected, and the blood collection tube was pulled out after the blood no longer flowed into the blood collection tube. Pull out the venous needle and place the blood collection tube vertically.

[0033] Plasma separation: Place blood collection tubes vertically in a refrigerator at 4...

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Abstract

The present invention relates to the field of biotechnology and firstly reveals that miR-19b plays an important role in osteoblast differentiation and can be used as a target for prevention and treatment of bone metabolic diseases (including osteoporosis, osteoproliferation, abnormal osteogenic differentiation, and loss of bone mass). The present application discloses the miRNA marker miR-19b associated with the bone metabolic diseases and an application thereof. An expression level of the miR-19b can distinguish between a population of the related bone metabolic diseases and a healthy population.

Description

technical field [0001] The present invention relates to the field of biotechnology. More specifically, it relates to a miRNA marker miR-19b related to bone metabolic diseases and its application. Background technique [0002] Osteoporosis is one of the most common middle-aged and elderly diseases, characterized by a decrease in the amount of bone tissue per unit volume. One of the most common complications of osteoporosis is vertebral compression fractures (Vertebral compression fractures, VCFs), fractures can cause long-term chronic pain, limited mobility and even life-threatening. In 2013, the Blue Book on the Prevention and Treatment of Osteoporotic Fractures in China reported that the risk of VCFs in my country is as high as 30% to 40%, and there are about 1.8 million new cases every year. It is estimated that by 2020, the cumulative number of patients will reach about 36.75 million. According to statistics from Shenzhen People's Hospital, more than 500 patients underg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/113
Inventor 孙梦舸管敏彭松林
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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