BCMA specific chimeric antigen receptor T cell and application thereof

A chimeric antigen receptor, cell technology, applied in application, anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, hybrid peptide, etc., can solve tissue and organ damage, CAR-T recognition error attack Normal cells, clinical side effects, etc.
CN109748968AActive Publication Date: 2019-05-14广州因明生物医药科技股份有限公司
2 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
广州因明生物医药科技股份有限公司
Publication Date
2019-05-14

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a specific chimeric antigen receptor (anti-BCMA scFv-CD8a-41BB-CD3 zeta) for human BCMA and application thereof. The chimeric antigen receptor is formed by a single-chain-antibody anti-BCMA scFv, a hinge region, a transmembrane region and an intracellular region in series. The chimeric antigen receptor is used for modifying human T lymphocyte, and the modified T lymphocyteis used for prevention and treatment of surface BCMA positive tumor and preparing of antitumor medicines.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to the field of tumor cell immunotherapy, in particular to a chimeric antigen receptor anti-BCMAscFv-CD8a-41BB-CD3ζ obtained by genetic engineering technology and T lymphocytes modified by the chimeric antigen receptor, the modified T lymphocytes can specifically recognize and kill tumor cells expressing BCMA on the surface, and the tumor cells are preferably multiple myeloma cells. Background technique

[0002] Intact antibodies have a larger relative molecular mass. Single-chain antibody (single chain antibody fragment, scFv) is a small-molecule antibody formed by connecting only the V region (VH) of the antibody heavy chain and the V region (VL) of the light chain through a synthetic linker. The relative molecular mass of single-chain antibody is small, easy to construct and express, and its immunogenicity is weak, so it is not easy to cause hypersensitivity and rejection. Single-chain antibodies are currently one of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More