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Pediatric wound face anti-infective dressing

A wound surface and anti-infection technology, applied in the field of medical supplies, can solve the problems of inability to provide a safe and sterile body surface contact environment during the wound recovery process, lack of anti-infection and antibacterial, increase children's pain, etc., and achieve preparation costs Inexpensive, significant anti-infection effect, low-equipment-dependent effect

Inactive Publication Date: 2019-05-17
李正浩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the defects in the prior art, the present invention provides a kind of anti-infection dressing for pediatric wound surface, which overcomes the simple structure and single function of traditional dressing, not only does not have the effect of anti-infection and bacteriostasis, but also cannot Provide a safe and sterile body surface contact environment for children's wound recovery process, and it is easy to breed bacteria and produce peculiar smell. In addition, children's body surface secretes vigorously. Less, easy to reverse osmosis, which brings a lot of troubles to the doctor's wound treatment, and also increases the technical problems of the children's pain. It has excellent comprehensive performance, remarkable anti-infection effect, good biocompatibility, and good penetration. It can quickly absorb the wound surface and discharge sweat and dirt, and has the advantages of safety and environmental protection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An anti-infection dressing for pediatric wounds, prepared by the following preparation method:

[0031] Ⅰ Polyprezinc modified hyaluronic acid: Add 1kg polyprezinc, 3kg hyaluronic acid, 0.3kg of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline into 15kg of tetrahydrofuran, and then add Stir and react at 50°C for 20 hours, then remove the solvent by rotary evaporation, wash with ethanol for 3 times, remove the ethanol by rotary evaporation, and finally place it in a vacuum drying oven at 80°C to dry to constant weight to obtain polypurizin modified hyaluronic acid;

[0032] II Preparation of chitosan modified by quaternary ammonium salt 15: Add 3kg of chitosan and 151kg of quaternary ammonium salt to 10kg of dimethyl sulfoxide, stir and react at 60°C, then precipitate in water, and wash the product 4 times with ethanol , and then dried in a vacuum oven at 75°C to constant weight;

[0033] Ⅲ Functionalized quaternary ammonium salt 15 modified chitosan: Add 1 kg of quaterna...

Embodiment 2

[0039] An anti-infection dressing for pediatric wounds, prepared by the following preparation method:

[0040] ⅠPolyprezinc modified hyaluronic acid: Add 1kg polyprezinc, 3.5kg hyaluronic acid, 0.35kg of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline to 17kg of acetone, and then Stir the reaction at 52°C for 21 hours, then remove the solvent by rotary evaporation, wash with ethanol for 4 times, remove the ethanol by rotary evaporation, and finally place it in a vacuum drying oven at 83°C to dry to constant weight to obtain polypurizin modified hyaluronic acid;

[0041] Ⅱ Preparation of chitosan modified by quaternary ammonium salt 15: Add 3.5kg of chitosan and 151kg of quaternary ammonium salt to 11.5kg of N,N-dimethylformamide, stir and react at 65°C, and then precipitate in water , and the product was washed with ethanol for 5 times, and then dried in a vacuum oven at 77°C to constant weight;

[0042] Ⅲ functionalized quaternary ammonium salt 15 modified chitosan: add 1 kg ...

Embodiment 3

[0048] An anti-infection dressing for pediatric wounds, prepared by the following preparation method:

[0049] Ⅰ Polyprezinc modified hyaluronic acid: Add 1kg polyprezinc, 4kg hyaluronic acid, 0.4kg of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline to 17kg of acetonitrile, and then add Stir and react at 55°C for 22 hours, then remove the solvent by rotary evaporation, wash with ethanol for 4 times, remove the ethanol by rotary evaporation, and finally place it in a vacuum drying oven at 85°C to dry to constant weight to obtain polypurizin modified hyaluronic acid;

[0050] II Preparation of chitosan modified by quaternary ammonium salt 15: Add 4kg of chitosan and 151kg of quaternary ammonium salt to 12.5kg of N-methylpyrrolidone, stir and react at 70°C, then precipitate in water, and wash the product with ethanol 5 times, and then dried in a vacuum oven at 79°C to constant weight;

[0051] Ⅲ Functionalized quaternary ammonium salt 15 modified chitosan: add 1 kg of quaternary ...

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PUM

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Abstract

The invention discloses a pediatric wound surface anti-infective dressing prepared in a following preparation method including the step of (1) preparation of polaprezinc modified hyaluronic acid; (2)preparation of quaternary ammonium salt 15 modified chitosan; (3) preparation of function quaternary ammonium salt 15 modified chitosan; (4) ion exchange; (5) preparation of surface modified carbon sponge; (6) preparation of functional composition; (7) dressing preparation and molding. The pediatric wound surface anti-infective dressing has the advantages of being excellent in comprehensive performance, remarkable in anti-infection effect, good in biocompatibility, good in osmosis effect, capable of absorbing sweat and dirt discharged from the wound surface quickly, safe in use and environmentally friendly.

Description

technical field [0001] The invention relates to the technical field of medical supplies, in particular to an anti-infection dressing for pediatric wounds. Background technique [0002] In the busy modern life, the human skin ranges from small abrasions to large surgical incisions and skin burns. We deal with wounds all the time. Once the wound is not treated properly in time, pathogenic bacteria will infect the wound, causing local redness, Swelling, heat, pain, and dysfunction. In mild cases, wound healing is slowed down. In severe cases, bacteria and toxins enter the blood circulation and cause symptoms such as sepsis, tetanus, and toxemia, which seriously threaten the lives and health of patients. Therefore, wound repair has become one of the most important and basic problems faced by surgery and even the whole medical field. [0003] At present, the clinical treatment of wounds is mainly in the form of external application of medical dressings. The main function of medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/46
Inventor 李正浩郭洁
Owner 李正浩
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