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Application of a tumor marker ca9 and uca1 in the preparation of a kit for non-invasive detection of the probability of bladder cancer

A tumor marker, non-invasive technology, applied in the field of detection kits, to achieve the effect of reducing pain and risk, stable vesicle structure, and convenient material collection

Active Publication Date: 2021-03-19
GUANGZHOU HENGTAI BIOTECH +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, domestic patents on exosomes mainly focus on the separation and detection of exosomes, but there are few public reports on the use of exosomes extracted from urine for auxiliary diagnosis of bladder cancer. Only Zhejiang University has published a urine exosome An integrated detection method and detection chip for body separation, enrichment and detection. By detecting cancer information in urine exosomes, it is expected to be used for non-invasive diagnosis and monitoring of bladder cancer. This method uses the unique transmembrane protein CD63 of exosomes A rapid ELISA method for the diagnosis of bladder cancer was established, but the screening of bladder cancer-specific tumor markers was not carried out

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  • Application of a tumor marker ca9 and uca1 in the preparation of a kit for non-invasive detection of the probability of bladder cancer
  • Application of a tumor marker ca9 and uca1 in the preparation of a kit for non-invasive detection of the probability of bladder cancer
  • Application of a tumor marker ca9 and uca1 in the preparation of a kit for non-invasive detection of the probability of bladder cancer

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Embodiment Construction

[0045] The non-invasive detection method of bladder cancer based on urinary exosomes of the present invention will be described in detail below with reference to the drawings and specific examples.

[0046] From September 2017 to March 2018, the inventor collected urine samples from 176 patients diagnosed with bladder cancer by cystoscopy and pathological diagnosis at Sun Yat-sen University Cancer Center, which was defined as the bladder cancer group. In addition, 123 urine samples were also collected. Urine samples from healthy volunteers were defined as the control group. All sample providers in this study were informed of the purpose of this study and signed informed consent.

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Abstract

The invention discloses use of tumor markers CA9 and UCA1 in the preparation of a kit for non-invasive detection of a probability of bladder cancer. The use can be used for initial screening and postoperative follow-up of suspected bladder cancer, reduce the frequency of cystoscopy, reduce the pain and risk of a patient, and have important significance for filling the blank of a domestic moleculardiagnosis product of bladder cancer in vitro.

Description

technical field [0001] The invention relates to the field of detection kits, in particular to the application of tumor markers CA9 and UCA1 in the preparation of non-invasive detection kits for bladder cancer probability. Background technique [0002] Bladder cancer refers to the most common malignant tumor of the urinary system that occurs on the bladder mucosa, with an average age of onset of about 65 years, of which about 90% are transitional cell carcinoma, and the other 10% are mainly squamous cell carcinoma and adenocarcinoma. The incidence rate of bladder cancer in the national tumor registration area is 6.61 / 100,000, ranking ninth in the incidence rate of malignant tumors. Due to the obvious characteristics of poor prognosis and easy recurrence, and the 5-year survival rate of bladder cancer patients with early detection and early treatment is greater than 90%, early diagnosis is of great significance to the treatment of this disease. Cystoscopy is currently the mos...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12N15/11
Inventor 文进李国荣曹艳张淑怡徐建华邓敏刘万里张朋张扬
Owner GUANGZHOU HENGTAI BIOTECH
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