A novel chemical modification of thiomethrin and its preparation method and application

A technology of chemical modification and thiomethrin, applied in chemical instruments and methods, preparation of organic compounds, botany equipment and methods, etc., can solve human and animal health threats, adverse effects on children's health, interference with biological functions, etc. problems, achieve good application prospects, solve the problem of drug resistance, and improve the effect of metabolic stability
CN109776368BActive Publication Date: 2021-05-28GUANGDONG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
GUANGDONG UNIV OF TECH
Publication Date
2021-05-28

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Abstract

The invention discloses a novel thiomethrin chemical modification and its preparation method and application. The present invention mainly transforms a terminal chlorine atom and an ester group on the transfluthrin, replaces a terminal chlorine atom with a trifluoromethyl group, and replaces the ester group with a thiol ester group structure, A series of novel thiomethrin compound structures containing a thiol structure are formed. These novel thiomethrin chemical modifications can improve metabolic stability and reduce environmental toxicity, and have certain insecticidal effects on larvae. Phenethrin is basically at the same concentration level, showing a mosquito-killing effect similar to that of bifenthrin, and can effectively solve the serious problem of outstanding resistance to existing pyrethroid insecticides. In addition, the invention has the advantages of simple reaction process, few reaction steps, high synthesis yield, short reaction cycle, good repeatability and the like.
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Description

technical field

[0001] The invention belongs to the technical field of pesticides for structure modification of medicine small molecules. More specifically, it relates to a novel thiomethrin chemical modification and its preparation method and application. Background technique

[0002] The hot and humid environment in summer brings good conditions for the breeding and infestation of mosquitoes. Mosquitoes, as one of the "four pests", have brought great distress to people's daily life. Not only the buzzing of mosquitoes will affect people's daily rest, work and study, but also people are usually indoors or outdoors. It is easy to be bitten by adult female mosquitoes, which can easily cause skin redness, swelling, pain and discomfort. A more serious problem is that mosquitoes can transmit as many as 80 kinds of diseases such as dengue fever, Japanese encephalitis, yellow fever, malaria and filariasis. Therefore, killing mosquitoes and avoiding mosquitoes is an important mea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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