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Application of Succinivibrio in drugs for prevention or treatment of altitude sickness

A Vibrio and succinic acid technology, applied in the field of biomedicine, can solve problems such as Vibrio succinic acid that have not yet been seen

Active Publication Date: 2019-05-24
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report on the application of succinic vibrio to altitude sickness

Method used

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  • Application of Succinivibrio in drugs for prevention or treatment of altitude sickness
  • Application of Succinivibrio in drugs for prevention or treatment of altitude sickness
  • Application of Succinivibrio in drugs for prevention or treatment of altitude sickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Example 1 Differences in the abundance of intestinal bacteria between the population in the plain area and the population in the plateau area

[0060] 1. Materials and methods:

[0061] 1.1 Study population

[0062] A case-control study was designed according to the STROBE statement, and 128 Tibetan male soldiers who served in a certain Chinese army from a certain month to a certain month in a certain year were included as the experimental group, and 128 plain Han soldiers were matched according to the age of the Tibetan soldiers. for comparison. Strictly control the two groups of people to have the same mixed diet of Chinese troops, maintain the same training environment and training intensity at an altitude of 3500 meters, quit smoking and drinking, and last for 3 months. Soldiers with chronic inflammatory diseases, oral antibiotics, acute infections, and gastrointestinal disorders were excluded.

[0063] 1.2 Stool sample collection

[0064] Each research subject ...

Embodiment 2

[0087] Example 2 Effect of Succinivibrio dextrinosolvens on high altitude heart disease model rats

[0088] Experimental animals: SD rats, purchased from Beijing Weitong Lihua Experimental Animal Co., Ltd.

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Abstract

The invention provides application of Succinivibrio in drugs for prevention or treatment of altitude sickness. The altitude sickness is acute altitude sickness and chronic altitude sickness occurringin the high altitude of 2000 m and above.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of succinic vibrio in the preparation of medicines for preventing or treating altitude sickness. Background technique [0002] The air in the plateau environment is thin, the atmospheric pressure and oxygen partial pressure are low, the climate is cold and dry, and the ultraviolet radiation is strong. People who migrate from the plains to the plateau or stay in the plateau for a short period of time, due to insufficient adaptability to the plateau environment, a group of diseases characterized by hypoxia are called altitude sickness. The symptoms generally manifest as headache, palpitation, fatigue, chest tightness, shortness of breath, Vomiting, loss of appetite, convulsions, trance, sudden decline in cognitive ability, etc. Signs include rapid heart rate, deep breathing, mildly abnormal blood pressure, edema of the face or limbs, and cyanosis of the lips....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61P39/00A23L33/135
Inventor 何昆仑贾倩赵晓静刘继轩贾志龙石金龙张曼丽陈卉宁王依慧
Owner GENERAL HOSPITAL OF PLA
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