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Substance for lowering blood pressure and preparation method and application thereof

A technology for fat-soluble substances and seeds, which can be used in medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, which can solve problems such as side effects and achieve good safety effects.

Inactive Publication Date: 2019-05-24
徐爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antihypertensive drugs usually need to be used in combination to enhance the antihypertensive effect, but long-term use still has various side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0024] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, heat to 120°C under 0.01atm vacuum to recover ethanol; then add 5kg of ether as unsaponifiable extractant for extraction, separate the upper layer extract, and heat to 85°C under 0.01atm vacuum to recover the extractant , to obtain 400g liquid substance, namely the present invention Hevea brasiliensis The unsaponifiable matter of the fat-soluble part of the seed.

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Embodiment 2

[0029] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0030] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 440g remaining liquid matter and be exactly the present invention Hevea brasiliensis The unsaponifiable matter...

Embodiment 3

[0035] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds, and the fat-soluble substance of 15kg seeds is extruded.

[0036] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 450g remaining liquid matter and be exactly the present invention Hevea brasiliensi...

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Abstract

The invention discloses a substance for lowering blood pressure and a preparation method and application thereof. The substance is the unsaponifiable matter of the fat-soluble substance of the seeds of Hevea brasiliensis. The preparation method includes: using the fat-soluble substance extracted from the seeds of Hevea brasiliensis as the raw material, subjecting the raw material to saponification, and performing separation and purification to obtain the substance which does not participate in the saponification. The substance used for lowering the blood pressure of patients with hypertensionis applicable to drugs, health-care food and food and free of side effects.

Description

technical field [0001] The invention discloses a substance for lowering blood pressure, an application and a preparation method thereof, and belongs to the fields of medicine and food. Background technique [0002] The number of people with high blood pressure and high blood pressure in my country has exceeded 330 million, and one out of every three adults suffers from high blood pressure. At present, there are about 130 million people with high blood pressure in my country who do not know that they have high blood pressure. Even among those who receive treatment, as many as 75% of them have not reached the control standard. According to the results recently released by the Center for Chronic Disease Prevention and Control of the Chinese Center for Disease Control and Prevention, the prevalence of hypertension in my country is showing a younger trend. Among young men aged 25 to 34, the prevalence of hypertension is as high as 20.4%. [0003] High blood pressure is a serious...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P9/12A61K131/00
Inventor 徐爽
Owner 徐爽
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