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Enema for treating hand-foot-mouth disease in children

A technology of hand, foot and mouth disease and enema, which is applied in the field of medicine, can solve the problems of lack of large-scale clinical trial research, adverse reactions and reproductive toxicity, and low level of evidence, and achieve comprehensive drug efficacy and functions, balance of yin and yang, and reasonable dosage Effect

Inactive Publication Date: 2019-06-04
西安大兴医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that early use of interferon α spray or atomization and intravenous infusion of ribavirin may have a certain effect, but there is currently a lack of large-scale clinical trials, and the level of evidence is low
Moreover, ribavirin has relatively high adverse reactions and reproductive toxicity, and common antiviral drugs, such as acyclovir, ganciclovir, adenosine monophosphate, etc., are ineffective in the treatment of hand, foot and mouth disease infection virus.

Method used

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  • Enema for treating hand-foot-mouth disease in children
  • Enema for treating hand-foot-mouth disease in children

Examples

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preparation example Construction

[0047] The preparation method of the enema for the above-mentioned treatment of hand-foot-mouth disease is carried out according to the following steps:

[0048] Step 1: Mix the traditional Chinese medicine raw materials Radix Radix Isatidis, honeysuckle, forsythia, burdock seed, scrophulariae, bellflower, and raw licorice in the formula, add water 8 times the total amount of traditional Chinese medicine raw materials for the first time, soak for 1 hour, boil and then decoct for 2 hours. Filtrate and collect the filtrate; add water 7 times the total amount of Chinese medicine raw materials for the second time, decoct for 2 hours after boiling, filter, and combine the filtrate;

[0049] Step 2: Concentrate the combined filtrate from Step 1 to 3 times the amount of the finished product, let it stand for 24 hours, and obtain the supernatant by alcohol precipitation;

[0050] Step 3: Concentrate the supernatant from step 2 to the required amount of the finished product, filter, su...

Embodiment 1

[0058] An enema for treating hand, foot and mouth disease, the prepared enema is composed of the following traditional Chinese medicine raw materials by weight:

[0059] Banlangen: 15g, Honeysuckle: 10g, Forsythia: 10g, Burdock: 10g, Scrophulariaceae: 10g, Campanulaceae: 10g, Raw Licorice: 6g.

[0060] The enema preparation method is as follows:

[0061] Step (1): Take Radix Isatidis, Honeysuckle, Forsythia, Burdock, Scrophulariae, Campanulaceae, and Raw Licorice according to the formula, add 8 times the amount of water for the first time, soak for 1 hour, boil and decoct for 2 hours, filter, and collect filtrate. For the second time, add 7 times the amount of water of the total amount of raw materials, boil and decoct for 2 hours, filter, and combine the filtrate;

[0062] In step (2), the filtrate of step (1) is reduced to 3 times the amount of the finished product, left to stand for 24 hours, and the supernatant is obtained by alcohol precipitation;

[0063] In step (3),...

Embodiment 2

[0067] An enema for treating children's hand-foot-mouth disease, the prepared enema is composed of the following traditional Chinese medicine raw materials by weight:

[0068] Banlangen: 12g, Honeysuckle: 10g, Forsythia: 10g, Burdock: 10g, Scrophulariaceae: 10g, Campanulaceae: 10g, Raw Licorice: 6g.

[0069] The enema preparation method is as follows:

[0070] Step (1): Take Radix Isatidis, Honeysuckle, Forsythia, Burdock, Scrophulariae, Campanulaceae, and Raw Licorice according to the formula, add 8 times the amount of water for the first time, soak for 1 hour, boil and decoct for 2 hours, filter, and collect filtrate. For the second time, add 7 times the amount of water of the total amount of raw materials, boil and decoct for 2 hours, filter, and combine the filtrate;

[0071] In step (2), the filtrate of step (1) is reduced to 3 times the amount of the finished product, left to stand for 24 hours, and the supernatant is obtained by alcohol precipitation;

[0072] In ste...

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Abstract

The invention discloses an enema for treating hand-foot-mouth disease in children. The enema for treating the hand-foot-mouth disease in the children is prepared from the following traditional-Chinese-medicine raw materials in parts by weight: 10-20 parts of radix isatidis, 6-15 parts of honeysuckle flowers, 6-15 parts of fructus forsythiae, 6-12 parts of great burdock achene, 9-15 parts of radixscrophulariae, 9-15 parts of radix platycodonis, and 2-10 parts of raw liquorice roots. The enema for treating the hand-foot-mouth disease in the children pays attention to traditional Chinese medicine theories. The enema for treating the hand-foot-mouth disease in the children adopts the radix isatidis as the sovereign drug by putting the effects of clearing away heat and detoxifying of the radixisatidis at an important position. The honeysuckle flowers with the effects of removing heat from Qi and eliminating toxic heat from the blood, as well as the fructus forsythiae with the effects of effecting relaxing upper Jiao so as to purge the heart of pathogenic fire, removing blood knot and eliminating Qi retention, as used together as the minister drugs. The radix scrophulariae with the effects of purging pathogenic fire, nourishing Yin, clearing away heat and cooling the blood, the great burdock achene with the effects of dispelling pathogenetic wind and heat, as well as the radix platycodonis with the effects of ventilating lung Qi and expelling pus, are used as the assistant drug. The raw liquorice roots with the effects of clearing away heat, detoxifying and regulating herbal properties are used as the envoy drug. The drugs synergistically take an effect, thereby achieving the effects of relieving exterior syndromes and clearing away internal heat. Thus, the enema for treating the hand-foot-mouth disease in the children is capable of effectively treating the hand-foot-mouth disease in the children, as well as relieving exterior syndromes and clearing away internal heat.

Description

technical field [0001] The invention belongs to medicine in the field of medicine, in particular to a medicine for treating hand, foot and mouth disease, in particular to an enema for treating children's hand, foot and mouth disease. Background technique [0002] Hand foot and mouth disease (Hand foot and mouth disease, HFMD) is a common infectious disease in children caused by enterovirus (EV) infection. 100,000 to 205.06 / 100,000, and the reported case fatality rate in recent years is between 6.46 / 100,000 and 51.00 / 100,000. As a common acute rash infectious disease in children, it mostly occurs in children under 5 years old. Clinically, it is characterized by maculopapular rash and herpes on the hands and feet, oral herpes, ulcers, and fever. In a small number of cases, serious complications such as heart, lung, and brain may occur. [0003] Ordinary HFMD manifests as sudden onset, fever, herpes and ulcers in the oral cavity (pharynx, hard palate, cheeks, gums, tongue, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/808A61K9/00A61P31/14
Inventor 李萌萌荆亚瑞王晓娟李振斌贺建军郑炳真
Owner 西安大兴医院
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