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Higher acetate compound, and solid dialysis agent using same

A technology of acetate compounds and solid state, which is applied in the field of advanced acetate compounds, which can solve the problems of lack of formulation stability and no reports of acetate compounds, etc., achieve excellent formulation stability, reduce acetic acid odor, and inhibit curing Effect

Active Publication Date: 2022-02-18
TOMITA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no report of an acetate compound capable of inhibiting the decomposition of glucose by itself without relying on pharmaceutical methods.
In addition, solid dialysis agents containing acetic acid also have disadvantages such as solidification due to storage, coloring, pH changes when dissolved in water, etc., and lack of formulation stability.
There has been no report on such an acetate compound having the effect of improving the stability of the formulation.

Method used

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  • Higher acetate compound, and solid dialysis agent using same
  • Higher acetate compound, and solid dialysis agent using same
  • Higher acetate compound, and solid dialysis agent using same

Examples

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preparation example Construction

[0109] The "solid dialysis agent" refers to a solid raw material used for the preparation of a dialysate. The solid dialysis agent of the present invention contains the above-mentioned higher acetate compound. The above-mentioned higher acetate compound can reduce the odor of acetic acid, and thus can suppress the deterioration of the work environment when clinically preparing dialysate. In addition, the above-mentioned higher acetate compound can also inhibit the decomposition of glucose, so when glucose is contained in the solid dialysis agent of the present invention, glucose can be stabilized. In addition, the solid dialysis agent of the present invention can suppress changes in pH due to storage, curing, coloring, and dissolution in water by including the above-mentioned higher acetate compound, and thus can also have excellent formulation stability.

[0110] [Types of solid dialysis agents]

[0111] The solid dialysis agent of the present invention can be used in the p...

Embodiment

[0140] Hereinafter, the present invention will be described concretely with reference to examples. However, the present invention is not construed as being limited to the following Examples.

Embodiment 1

[0143]Put 20.0 kg of glacial acetic acid, 24.6 kg of anhydrous sodium acetate, and 18.3 kg of purified water into a filter drier (manufacturer: TANABE WILLTEC Co., Ltd., model: TR25F), and stir while heating until the product temperature reaches 105°C. A mixture of dissolved glacial acetic acid and anhydrous sodium acetate was obtained. Stirring was continued while maintaining the temperature to evaporate and concentrate about 9 kg of the mixed liquid, and then the heating was stopped. Then, while continuing to stir, it cooled until the product temperature became 42 degreeC, and dried under reduced pressure at -96--98kPa with stirring until the product temperature exceeded 60 degreeC. The total time for drying under reduced pressure is 150 minutes. For the first 60 minutes from the start of drying under reduced pressure, the temperature of the jacket heat medium is kept at 50-55°C, and for the next 90 minutes, the temperature of the jacket heat medium is kept Periodically con...

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Abstract

An object of the present invention is to provide an acetate compound capable of reducing the smell of acetic acid and suppressing the decomposition of glucose even if it coexists with glucose. In the high-level acetate compound comprising acetic acid-sodium acetate mixed crystals, in X-ray powder diffraction measurement, diffraction peak A is observed at the position of 2θ=8.8°±0.2°, and observed at the position of 2θ=22.3°±0.2° To the diffraction peak B, the ratio Ia / Ib of the integrated intensity Ia of the diffraction peak A and the integrated intensity Ib of the diffraction peak B is less than 1.447, the compound can effectively inhibit the volatilization of acetic acid, can reduce the smell of acetic acid, and even with glucose Coexistence can also inhibit the breakdown of glucose.

Description

technical field [0001] The present invention relates to higher-order acetate compounds comprising acetic acid-sodium acetate mixed crystals. More specifically, the present invention relates to a higher acetate compound comprising acetic acid-sodium acetate mixed crystals, capable of reducing the odor of acetic acid, and capable of inhibiting the decomposition of glucose even if it coexists with glucose. Furthermore, the present invention relates to a solid dialysis agent using the higher acetate compound. Background technique [0002] Among hemodialysates, bicarbonate dialysates using sodium bicarbonate are the mainstream in order to correct the acid-base balance, and acid must also be added in order to make the dialysate neutral. In addition, if the electrolyte components contained in the bicarbonate dialysate are coexisted and circulated in the same container, carbon dioxide will be generated in the container and become very unstable. Therefore, as a dialysis agent used i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C53/08A61K47/04A61K47/12A61K47/26C07C51/43C07C53/10
CPCC07C51/43C07C53/08C07C53/10C07B2200/13A61P7/08C07C51/41A61K47/12A61K47/26
Inventor 吉本由典菊石纯也
Owner TOMITA PHARMA