Bifunctional probe for identifying iron ions and fluoride ions, preparation and application of bifunctional probe

A bifunctional, iron ion technology, applied in the field of bifunctional probes for identifying iron ions and fluoride ions, achieves the effects of high synthesis yield, simple synthesis steps and stable optical properties

Active Publication Date: 2019-06-18
UNIV OF JINAN
View PDF19 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, using the same fluorescent probe to detect iron ions and fluoride ions respectively is rarely reported. Patent CN104788344A discloses a dual-functional probe with anthracene as the parent, which can detect iron ions and fluoride ions
However, no probes based on Schiff base compounds with this function have been reported.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bifunctional probe for identifying iron ions and fluoride ions, preparation and application of bifunctional probe
  • Bifunctional probe for identifying iron ions and fluoride ions, preparation and application of bifunctional probe
  • Bifunctional probe for identifying iron ions and fluoride ions, preparation and application of bifunctional probe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Preparation of bifunctional probes

[0053] 0.204g 3-acetyl-4-hydroxycoumarin and 0.144g 8-aminoquinoline were dissolved in 60mL methanol solution, stirred and heated to reflux for 8h; after the reaction mixture was concentrated by rotary evaporation, it was separated by column chromatography (petroleum ether / acetic acid Ethyl ester=7:3, v / v), rotary evaporation, and vacuum drying to obtain pure product 4-hydroxyl-3-[1-(quinoline-8-imino)-methyl]-chromen-2-one , yield 84.9%. NMR characterization is as follows: 1 H NMR (400MHz, CDCl 3 )δ, 9.10(d, J=4.2Hz, 1H), 8.37(d, J=8.2Hz, 1H), 8.19(d, J=8.2Hz, 1H), 7.93-7.98(m, 1H), 7.71( d,J=4.2Hz,2H),7.58-7.65(m,2H),7.27-7.32(m,2H),2.77(s,3H). 13 C NMR (400MHz, CDCl 3 )δ, 150.92, 134.07, 129.11, 128.20, 126.46, 123.64, 122.39, 116.64, 77.22, 21.67.

Embodiment 2

[0054] Example 2: Investigation of the ability of the bifunctional probe of the present invention to recognize iron ions

[0055] The probe molecule (prepared in Example 1) was formulated into 2×10 -5 M in DMF solution, and then add 10equiv of various metal ions Fe 3+ ,Hg 2+ ,Al 3+ ,Mn 2+ ,Mg 2+ ,Zn 2+ , measure the UV-Vis absorption spectrum of the blank solution and the mixed solution, the results are as follows figure 1 shown. It was found experimentally that only by adding Fe 3+ , the original probe molecule's maximum absorption peak at 324nm had a significant blue shift to 296nm (Δλ=28nm), and the maximum absorption intensity also increased from 0.26 to 0.76 (2.9 times). However, other metal ions do not change significantly, indicating that the bifunctional probe molecule of the present invention can selectively recognize iron ions.

Embodiment 3

[0056] Example 3: Investigation of the ability of the bifunctional probe of the present invention to recognize fluoride ions

[0057] The probe molecules and iron ions (Fe 3+ ) at a molar ratio of 1:1 to form a probe-iron ion complex, and the probe-iron ion complex was prepared as 2×10 -5 DMF solution of M, add various anions F - , Cl - , Br - , HSO 4 - , measure the UV-Vis absorption spectrum of the solution, the results are as follows figure 2 As shown, it was found that when 10 equiv of fluoride ions were added, the absorption intensity decreased significantly, which was at the same level as the recognition intensity of the probe molecule, which indicated that the probe-iron ion complex could further selectively recognize fluoride ions.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a bifunctional probe for identifying iron ions and fluoride ions, a preparation and application of the bifunctional probe. The bifunctional probe is of a structure representedby a formula I described in the descriptions of the invention. The synthesis method of the bifunctional probe of the invention is simple and enables a high yield. The bifunctional probe can realize the detection of iron ions and fluoride ions and is reversible in the identification of the fluoride ions.

Description

technical field [0001] The invention relates to the technical field of ion detection, in particular to a bifunctional probe for identifying iron ions and fluorine ions and its preparation and application. Background technique [0002] Iron ions are indispensable substances in many physiological processes of human beings. It is the core part of hemoglobin, participates in the synthesis of hemoglobin, myoglobin, cytochrome, cytochrome oxidase, peroxidase and catalase in the process of oxygen transfer, and plays an important role in metabolic activities; however, After water or food is contaminated by iron ions, if the content is too high after drinking or eating and entering the human body, it will cause great damage to the heart, liver, and pancreas, and even cause life-threatening in severe cases. Therefore, whether it is the lack of iron or excessive intake will cause the disorder of the life system, the detection of iron ions is widely concerned by the medical and biochem...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64G01N21/33G01N21/78
Inventor 刘志莲张书香牟佳伟杨震冯子琦王兆萱于诗雨
Owner UNIV OF JINAN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap