Pharmaceutical composition for treatment of duodenal ulcers and preparation method of pharmaceutical composition

A technology of duodenal ulcer and composition, which is applied in the direction of drug combination, pharmaceutical formula, active ingredients of hydroxyl compounds, etc., can solve the problems of inability to eliminate pain, poor curative effect, long healing period, etc. Drug resistance, improved healing ability, fast onset effect

Pending Publication Date: 2019-06-21
GUANGZHOU PHGO BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are few medicines for treating duodenal ulcer on the market at present, and the cure period of these medicines is long, the curative effect is not good, and it cannot eliminate the patient's pain and improve the patient's discomfort in a short time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] The preparation method of this yolk immunoglobulin composition comprises:

[0023] (1) Bacteria after inactivation treatment are divided into 25-40% of cluster A type B hemolytic streptococci, 15-20% of Staphylococcus aureus, 10-15% of Pseudomonas aeruginosa, 10-15% of Escherichia coli, and Helicobacter pylori. 10-15% of Bacillus and 10-15% of Candida albicans are mixed to obtain a strain mixture; after dissolving the strain mixture, a composite antigen is obtained;

[0024] Further, after dissolving the bacterial strain mixture, the step of preparing the composite antigen comprises: mixing the dissolved bacterial strain mixture with Freund's adjuvant at a mass ratio of 1:0.5-1.5 to obtain a milky whole bacterial composite antigen, and then Milky whole bacteria compound antigen is pulverized and homogenized.

[0025] Further, the ratio of each colony in the preparation of the strain mixture is: 30-35% of cluster A type B hemolytic streptococcus, 16-19% of Staphylococcu...

Embodiment 1

[0047] The present embodiment provides a kind of pharmaceutical composition for the treatment of duodenal ulcer, which comprises:

[0048] Yolk immunoglobulin composition 6Kg, coptis 9Kg, honeysuckle vine 7Kg, dandelion 2Kg, borneol 5Kg, alum 7Kg, acetylsalicylic acid 7Kg, bletilla striata 2Kg and blood jerky 3Kg.

[0049] Its preparation method includes:

[0050] Mix coptis, honeysuckle, dandelion, bletilla striata and dried blood, mix with water according to the ratio of solid to liquid 1:7, and extract the medicinal solution by sonic vibration extraction method, the power of ultrasonic vibration extraction method is 120KHz, and the time is 42min;

[0051] After the medicinal solution is mixed with alum and borneol, it is concentrated to obtain an extract;

[0052] Then the extract is mixed with egg yolk immunoglobulin composition and acetylsalicylic acid, and dried in vacuum.

[0053] Wherein, the preparation method of yolk immunoglobulin composition comprises:

[0054] Ba...

Embodiment 2

[0057] The present embodiment provides a kind of pharmaceutical composition for the treatment of duodenal ulcer, which comprises:

[0058] Yolk immunoglobulin composition 10Kg, coptis 6Kg, honeysuckle 3Kg, dandelion 5Kg, borneol 8Kg, alum 3Kg, acetylsalicylic acid 3Kg, bletilla striata 5Kg and blood jellyfish 6Kg.

[0059] Its preparation method includes:

[0060] Mix coptis, honeysuckle, dandelion, bletilla striata and dried blood, mix with water according to the ratio of material to liquid 1:6, and extract the medicinal solution by sonic vibration extraction method, the power of ultrasonic vibration extraction method is 80KHz, and the time is 45min;

[0061] After the medicinal solution is mixed with alum and borneol, it is concentrated to obtain an extract;

[0062] Then the extract is mixed with egg yolk immunoglobulin composition and acetylsalicylic acid, and freeze-dried at low temperature to obtain the product.

[0063] Wherein, the preparation method of yolk immunogl...

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PUM

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Abstract

The invention provides a pharmaceutical composition for the treatment of duodenal ulcers and a preparation method of the pharmaceutical composition and relates to the field of drugs. The pharmaceutical composition comprises a yolk immunoglobulin composition, coptis chinensis, honeysuckle stem, dandelion, borneol, alum, acetylsalicylic acid, bletilla and sangusis draconis. The preparation method includes: mixing the coptis chinensis, honeysuckle stem, dandelion, bletilla and sangusis draconis with water according to the solid-liquid ratio of 1:6-8 and extracting liquid by an acoustic shock extraction method; mixing the liquid with the alum and borneol to obtain an extract after concentration; mixing the extract with the yolk immunoglobulin composition and acetylsalicylic acid before vacuumdrying. The pharmaceutical composition has the advantages of strong antibacterial and anti-inflammatory effect and good bactericidal effect on a variety of pathogenic bacteria, and is not easy to produce drug resistance, fast in treatment of the duodenal ulcers and good in curative effect for the treatment of the duodenal ulcers.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating duodenal ulcer and a preparation method thereof. Background technique [0002] Duodenal ulcer is one of the common diseases and frequently-occurring diseases among Chinese population, and it is a common type of peptic ulcer. Occurs in winter and spring when the climate changes greatly. Male incidence rate is significantly higher than female. It is closely related to abnormal gastric acid secretion, Helicobacter pylori infection, non-steroidal anti-inflammatory drugs, irregular life and diet, work and external pressure, smoking, drinking and mental and psychological factors. Duodenal ulcers mostly occur in the duodenal bulb, mostly in the anterior wall, followed by the posterior wall, inferior wall, and upper wall. [0003] Although there are fewer medicines for treating duodenal ulcer on the market at present, and such medicines have a long cu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/40A61K39/395A61P1/04A61P31/04A61K36/898A61K33/06A61K31/616A61K31/045
Inventor 蒙晓符美燕蒙永祥农定猛叶梦婕
Owner GUANGZHOU PHGO BIOTECH
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