Bone tissue engineering stent

A bone tissue engineering and metal-based technology, which is applied in the field of degradable bone tissue engineering scaffolds, can solve the problems of influence on mechanical properties, limited improvement of mechanical properties of scaffolds, difficulty in meeting mechanical performance requirements of bone tissue scaffolds, etc., and achieve good mechanical properties , improve mechanical properties, and repair large bone defects

Pending Publication Date: 2019-06-28
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Chinese patent document whose publication number is CN103845762A discloses a method for laser preparing porous bone scaffold and adding zinc oxide to improve performance, but it only adds a small amount of ZnO powder to the raw material of β-TCP to make porous scaffold, which has great influence on scaffold mechanics. The improvement of performance is limited; and the Chinese patent document whose publication number is CN104258458A discloses a kind of biodegradable open-pore porous zinc and zinc alloy biomaterial, although it is mentioned that the material can be used as a new generation of degradable bone tissue engineering scaffold, but the development The mechanical properties of zinc materials with holes will be greatly affected; the above two tissue engineering scaffolds containing zinc-based metals are still difficult to meet the mechanical performance requirements of large bone defects on bone tissue scaffolds

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Bone tissue engineering stent
  • Bone tissue engineering stent
  • Bone tissue engineering stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A preferred structure of the bone tissue engineering scaffold of the present invention is as follows: figure 1 As shown, its grid-shaped support 11 is cylindrical, with a diameter of 1-5cm and a height of 2-10cm. There are four cylindrical support columns 12 inside the support, with a diameter of 0.3-0.8mm, more preferably 0.4 -0.6mm, the positions of the supporting columns can be arranged symmetrically or arbitrarily, the shape of the grid 13 of the cylindrical support is square, the diagonal length of the grid is 0.5-2mm, and its size is based on the porous zinc-based metal ball and β - It is desirable that TCP particles do not come out. According to actual needs, the internal support column 12 in this embodiment may also be absent. Further, the hollow grid-shaped bracket 11 and its internal support column 12 may be made of pure titanium or titanium alloy with excellent mechanical properties, but they can also be It can be made of degradable zinc-based metal material...

Embodiment 2

[0060] For a large bone defect of the femoral shaft with a length of about 5 cm, a cylindrical mesh-like scaffold was first designed according to the shape of the bone defect, and the outer layer of the scaffold and the inner support column were prepared with TC4 titanium alloy as the raw material. The scaffold was designed to be 3.5 cm in diameter and 5 cm in height. Sub-cylindrical, the grid holes of the bracket are designed as square or rhombus, with a long diameter of 0.5mm, or the grid holes are designed as circular, with a diameter of 0.5mm, and 4 supporting columns with a diameter of 0.5mm are arranged inside. Then select Zn-1Sr alloy (Sr1wt.%, ultimate tensile strength UTS=160MPa, yield strength YS=120MPa, elongation>30%) to prepare porous zinc-based solid metal balls, and the diameter of the metal balls is 0.5-5mm. The laser ablation method is used to drill holes on Zn-1Sr metal balls with a diameter of 0.2mm and a porosity of 60%-90%. Select commercially available β-T...

Embodiment 3

[0066] For a patient with proximal humeral tumor resection, a spherical bone defect with a diameter of about 3 cm remained after surgery. First, a spherical mesh scaffold was designed according to the shape of the bone defect, and Zn-0.8Li-0.1Mg alloy (Li0.8wt.%, Mg0.1wt.%, UTS=680MPa, YS=540MPa, elongation 10%) was used as the raw material. The design of the outer bracket and the inner support column, the size of the bracket is based on the shape of the paste and bone defect. The bracket is designed as a spherical bracket with a diameter of 3cm. The grid holes of the bracket are designed to be square or diamond-shaped with a long diameter of 0.5mm, or the grid holes are designed to be circular with a diameter of 0.5mm. There are three supports with a diameter of 0.5mm inside. column. Then choose Zn-0.8Mg alloy (Mg0.8wt.%, UTS=370MPa, YS=300MPa, elongation 10%) to prepare zinc-based metal balls (diameter ranging from 0.5-5mm). Use laser ablation to drill holes on Zn-0.8Mg me...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a bone tissue engineering stent. The bone tissue engineering stent comprises a hollow latticed stent and a porous zinc-based metal ball, wherein the hollow latticed stent is filled with the porous zinc-based metal ball, the porous zinc-based metal ball can be a solid ball of which the surface is provided with hole grooves and also be a fluffy ball formed by rolling a metalwire; the stent is also provided with internal supporting columns to provide an excellent mechanical property; the stent can be filled with beta-TCP particles to be enriched in bone marrow mesenchymlstem cells. Combined with the latticed stent prepared from titanium or zinc-based metal and the internal supporting columns of the latticed stent, the bone tissue engineering stent with the excellentmechanical property is prepared, the porous zinc-based metal ball in the bone tissue engineering stent can promote osteogenic differentiation, inhibit osteoclast differentiation, promote the regeneration and ingrowth of bone tissue while providing the support, and then is replaced by the bone tissue during degradation, and the beta-TCP particles can be enriched in the bone marrow mesenchyml stem cells and promote bone repair. The bone tissue engineering stent can be applied to the large-segment bone defect of a weight-bearing part, promote bone tissue regeneration on the basis of mechanical support, and achieve the curative effect of repairing the large-segment bone defect.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and relates to a bone tissue engineering support, in particular to a degradable bone tissue engineering support capable of promoting bone repair. Background technique [0002] Medical inert metal materials represented by stainless steel, titanium alloys, cobalt-based alloys, and nickel-titanium shape memory alloys are the earliest medical materials used in the human body. Good capacity and other characteristics, it has become the largest and most widely used medical biomaterial in clinical practice. However, after centuries of use, people are not satisfied with the traditional properties of medical inert metal materials. Traditional medical inert materials also have some inherent defects, such as the stress shielding effect caused by the high elastic modulus of medical inert metal materials in orthopedic applications, and long-term complications of cardiovascular stents such as stent thrombos...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/91A61F2/88
Inventor 贾博曲新华
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap