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A kind of solidifying solution that can regulate the injectability of calcium phosphate bone cement and its preparation method and application

A calcium phosphate bone cement, injectable technology, applied in medical science, prosthesis, etc., can solve problems such as easy liquid-solid separation, decrease in compressive strength, increase in fluidity, etc., and achieve good injectability and compressive strength , active chemical properties, the effect of improving the compressive strength

Active Publication Date: 2021-06-11
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to epidemiological surveys, the compressive strength of cancellous bone is between 20-45MPa, and the compressive strength of calcium phosphate bone cement after curing is generally between 20-30MPa; at the same time, in clinical minimally invasive surgery, calcium phosphate Bone cement has the disadvantage of easy liquid-solid separation during injection, resulting in low raw material utilization
In order for calcium phosphate bone cement to be applied in the repair of cancellous bone defects, the injectability and compressive strength of calcium phosphate bone cement paste must be improved. Some studies have introduced a second phase into the solid phase of bone cement, such as nano ZrO 2 , carbon fiber and other reinforced bone cement, but because there is no chemical bond formed between the second phase and the solid phase, liquid phase, and cured product, it cannot play the role of connecting the solid-liquid phase. Although the compressive strength has been significantly improved, the bone cement liquid The phenomenon of solid separation still exists; some scholars also introduce viscous stabilizers such as chitosan and modified starch into the liquid phase to make the slurry form a hydrogel to increase the fluidity of the bone cement slurry, but the experimental results show that the compressive strength The strength has decreased by 10-20%. This is because the stabilizer increases the fluidity of the bone cement paste, the bone cement is difficult to solidify and form, and the calcium-deficient hydroxyapatite grains of the product are too small to form a cross network, resulting in a decrease in compressive strength. decline

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 1.984g of α-tricalcium phosphate powder and 0.016g of β-tricalcium phosphate powder as solid phase. Dissolve 7% citric acid monohydrate, 8% disodium hydrogen phosphate dodecahydrate, 1% ascorbic acid and 1% dextran sulfate sodium salt in deionized water with a mass fraction of 7%, completely dissolve at 40°C with a magnetic stirrer, Prepared into a solidified solution. Calcium phosphate bone cement was obtained by uniformly blending 0.8mL solidified solution and 2g solid phase powder.

[0027] The bone cement has good slurry cohesion during the extrusion injection process, no liquid-solid separation phenomenon occurs, the injectability is 88.3%, the slurry pH is 4.9, the curing time is 11min, the compressive strength is 36.2MPa, and the cured product has Osteoinductive calcium-deficient hydroxyapatite.

Embodiment 2

[0029] Weigh 0.7936g α-tricalcium phosphate powder and 0.0064g β-tricalcium phosphate powder as solid phase. Dissolve 7% citric acid monohydrate, 8% disodium hydrogen phosphate dodecahydrate, 6% ascorbic acid and 1% itaconic acid in deionized water, dissolve completely at 40°C with a magnetic stirrer, and prepare a solidified liquid. Calcium phosphate bone cement was obtained by uniformly mixing 0.36mL of solidified liquid and 0.8g of solid phase powder.

[0030] The bone cement has good slurry cohesion during the extrusion injection process, no liquid-solid separation phenomenon occurs, the injectability is 81.7%, the slurry pH is 4.5, the curing time is 7min, the compressive strength is 38.9MPa, and the cured product has Osteoinductive calcium-deficient hydroxyapatite.

Embodiment 3

[0032] Weigh 1.984g of α-tricalcium phosphate powder and 0.016g of β-tricalcium phosphate powder as solid phase. Dissolve 7% citric acid monohydrate, 8% disodium hydrogen phosphate dodecahydrate and 1% dextran sulfate sodium salt in deionized water with a mass fraction of 7%, dissolve completely at 40°C with a magnetic stirrer, and prepare a solidified solution . Calcium phosphate bone cement was obtained by uniformly mixing 0.7mL of solidified solution and 2g of solid phase powder.

[0033] The bone cement has good cohesion in the extrusion injection process, no liquid-solid separation phenomenon, the injectability is 80.6%, the slurry pH is 4.8, the curing time is 11.5min, the compressive strength is 34.6MPa, and the cured product is An osteoinductive mixture of calcium-deficient hydroxyapatite and octacalcium phosphate.

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Abstract

The invention discloses a solidifying liquid capable of regulating the injectability of calcium phosphate bone cement and its preparation method and application. The mass percentage of the solidifying liquid composition is as follows: citric acid monohydrate 6-8%, hydrogen phosphate dodecahydrate Disodium 7-9%, the total amount of acidic organic components is not more than 10%, and the balance is water. Compared with the prior art, the technology of the present invention has the following advantages: the method for preparing the solidified liquid in the present invention is simple, fast and efficient; The strength is good; in addition, in the actual use process, adding acidic organic components, such as one of different contents of ascorbic acid, dextran sulfate sodium salt, itaconic acid or a combination thereof, can obtain a compressive strength of 20 The liquid-phase formula of bone cement in the range of ‑40MPa can customize bone cement with high injectability and different compressive strength on demand.

Description

technical field [0001] The invention relates to a solidifying solution capable of regulating the injectability of calcium phosphate bone cement, a preparation method and application thereof, and belongs to the technical field of calcium phosphate bone cement. Background technique [0002] Bone cement is an important material for bone defect treatment and prosthesis fixation. It is easy to operate. When using it, the solid phase and liquid phase are mixed in a certain proportion and then filled into the damaged part. The solid phase and liquid phase react and gradually harden. Fixation on the prosthesis can ensure immediate postoperative stability and allow early postoperative weight bearing. Bone cement mainly includes polymethyl methacrylate (PMMA), calcium sulfate (CaSO 4 0.5H 2 O) and calcium phosphate (CPC) bone cement, wherein PMMA bone cement has poor biocompatibility, is non-degradable, and the monomer is toxic. A large amount of heat is released during the polymeri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/50
Inventor 董寅生潘娅妮占韵
Owner SOUTHEAST UNIV