Imidazole compound of 1,3,4-oxadiazolyl (thiadiazolyl) and preparation method and application of compound

A compound and imidazole technology, applied in the field of imidazole compounds and their preparation, can solve problems such as hindering normal growth, development, and affecting human economic benefits

Active Publication Date: 2019-06-28
GUIZHOU UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Plant diseases lead to a series of morphological, physiological and biochemical pathological changes in plants under the influ...

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  • Imidazole compound of 1,3,4-oxadiazolyl (thiadiazolyl) and preparation method and application of compound
  • Imidazole compound of 1,3,4-oxadiazolyl (thiadiazolyl) and preparation method and application of compound
  • Imidazole compound of 1,3,4-oxadiazolyl (thiadiazolyl) and preparation method and application of compound

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Embodiment 1

[0066] Below by embodiment the present invention will be further described. It should be understood that the methods described in the examples of the present invention are only used to illustrate the present invention, rather than to limit the present invention, and any simple improvement to the preparation method of the present invention under the premise of the concept of the present invention belongs to the protection scope of the present invention. All raw materials and solvents used in the examples are commercially available products.

[0067] Preparation of intermediate 5-trifluoromethyl-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester (3):

[0068] Reference [Zhou, L.; Wang, P.Y.; Zhou, J.; Shao, W.B.; Fang, H.S.; Wu, Z.B.; Yang, S. *Antimicrobial activities of pyridinium-tailored pyrazoles bearing 1,3,4-oxadiazole scaffolds .J.Saudi Chem.Soc.,2017,21,852-860]. In a 250mL three-neck flask with a condenser and a thermometer, add ethyl trifluoroacetoacetate (186.03mmo...

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Abstract

The invention relates to an imidazole compound of 1,3,4-oxadiazolyl (thiadiazolyl) and a preparation method and application of the compound. The compound has a structure shown as a general formula (I)and a good inhibition effect on plant pathogenic bacteria such as xanthomonas oryzae pv.oryzae, xanthomonas axonopodis pv.citri and pseudomonas syringae pv.actinidiae.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to an imidazole compound containing 1,3,4-oxa(thia)diazolyl and its preparation method and application. Background technique [0002] For a long time, plant diseases have been an important factor affecting the economic increase of crops. Plant diseases lead to a series of morphological, physiological and biochemical pathological changes in plants under the influence of biological or abiotic factors, hindering the normal growth and development process, thereby affecting human economic benefits. Therefore, designing and synthesizing green small-molecule pesticides with high activity is an important part of the current research and development of new pesticides. Since thioether compounds and azole compounds containing 1,3,4-oxa(thia)diazolyl groups exhibit broad-spectrum biological activities against agricultural bacteria, commercialized agents include the agricultural fun...

Claims

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Application Information

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IPC IPC(8): C07D413/14A01N43/824A01P1/00A01P3/00
Inventor 王培义张飞陆帮明罗敏李清宝赵高山刘洪武杨松
Owner GUIZHOU UNIV
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