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Isoflavone eye drop liquid and preparation method and application thereof

A technology of eye drops and isoflavones, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effect of high stability and great application prospects

Inactive Publication Date: 2019-07-02
GUANGDONG WHOLEWIN TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, there is no report of making soy isoflavones into eye drops for the treatment of retinoblastoma and / or macular degeneration

Method used

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  • Isoflavone eye drop liquid and preparation method and application thereof
  • Isoflavone eye drop liquid and preparation method and application thereof
  • Isoflavone eye drop liquid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～6

[0026] Prepare isoflavone eye drops with different component contents, as shown in Table 1:

[0027] Table 1 Embodiment 1~6 eye drop formula

[0028]

[0029] According to the technical scheme of the present invention, the optional auxiliary materials for preparing isoflavone eye drops are not limited to the ones listed in the above table, and can also have the following multiple options:

[0030] Use an osmotic pressure regulator to adjust the osmolality of the finished eye drops to be 280-330mOsmol / kg; the osmotic pressure regulator is one of sodium chloride, potassium chloride, glucose, boric acid, borax, glycerin, mannitol or Various.

[0031] Use a pH regulator to adjust the pH of the finished eye drops to 5.0 to 7.0; the pH regulator is disodium hydrogen phosphate-sodium dihydrogen phosphate buffer, potassium dihydrogen phosphate-dipotassium hydrogen phosphate buffer, boric acid-borax One or more of buffer, sodium hydroxide, sodium bicarbonate, citric acid, sodium c...

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PUM

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Abstract

The invention discloses an isoflavone eye drop liquid and a preparation method and an application thereof. The isoflavone eye drop liquid includes the following components: 0.001%-0.1% (w / v) of soy isoflavones, 0.3-0.7% (w / v) of a cosolvent, 0.001%-0.1% (w / v) of an antibacterial agent, 0.1%-2% (w / v) of [belta]-nicotinamide mononucleotide, an osmotic pressure regulator, a pH regulator, with the balance being injection water. The eye drop liquid of the invention has good efficacy of inhibiting ocular tumors of children such as retinoblastoma and ocular neovascularization such as fundus maculopathy, has no stimulus, is safe, is high in stability, and has great application prospects.

Description

technical field [0001] The invention belongs to the technical field of ophthalmic preparations, and more specifically, relates to an isoflavone eye drop and its preparation method and application Background technique [0002] Isoflavones, also known as soybean isoflavones, are phenolic compounds based on benzochromone rings formed by cyclization of cinnamoyl-CoA side chains during the metabolism of phenylalanine in plants. Its 3-phenyl derivatives Isoflavones are plant secondary metabolites. Soy isoflavones can prevent menopausal syndrome, prevent and improve osteoporosis, prevent cardiovascular disease, prevent Alzheimer's disease, beautify, and delay aging; studies have found that soy isoflavones have effects on breast cancer, colon cancer, lung cancer, prostate cancer and skin Cancer and leukemia have obvious therapeutic effect, soy isoflavones can also prevent ovarian cancer, colon cancer, gastric cancer and prostate cancer. [0003] Retinoblastoma (Rb) and macular deg...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K47/38A61K47/32A61K31/352A61P27/02A61P35/00
CPCA61K9/0048A61K9/08A61K31/352A61K47/32A61K47/38A61P27/02A61P35/00
Inventor 吴绮峰
Owner GUANGDONG WHOLEWIN TECH
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