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New uses for gemfibrozil

A technology of gemfibrozil and a drug, applied in the field of glioma treatment, can solve the problem that adjuvant treatment has not yet been reported, and achieve the effect of improving the treatment effect and enhancing the killing effect.

Active Publication Date: 2022-01-18
葛鹏飞
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0006] Although gemfibrozil has been used to treat hyperlipidemia for many years, its adjuvant therapy for tumors, especially for glioma, has not been reported yet

Method used

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  • New uses for gemfibrozil
  • New uses for gemfibrozil
  • New uses for gemfibrozil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Gemfibrozil enhances the therapeutic effect of temozolomide on glioma

[0029] 1. Reagents:

[0030] Gemfibrozil was purchased from Selleck Company, and used to prepare the required concentration with DMSO.

[0031] Temozolomide was purchased from Sigma.

[0032] Human glioma U251 and U273 cells were purchased from Shanghai Jikai Biotechnology Company.

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Abstract

The new use of gemfibrozil relates to the field of glioma treatment. Application of the gemfibrozil of the present invention in improving the therapeutic effect of temozolomide on glioma. The application of the gemfibrozil of the present invention in enhancing the killing effect of temozolomide on glioma cells. A pharmaceutical composition for preventing and / or treating glioma of the present invention, the pharmaceutical composition contains gemfibrozil and temozolomide. It has been proved by experiments that gemfibrozil can improve the therapeutic effect of temozolomide on glioma, has synergistic effect of temozolomide on killing glioma cells, and can enhance the killing effect of temozolomide on glioma cells. The preparation of gemfibrozil and temozolomide into a drug for preventing and / or treating glioma can improve the therapeutic effect of temozolomide on glioma. The application of gemfibrozil in the preparation of drugs for the prevention and / or treatment of glioma opens up a new application of gemfibrozil, and provides a new therapy and treatment plan for the treatment of the chronic disease of glioma.

Description

technical field [0001] The invention relates to the technical field of glioma treatment, in particular to a new application of gemfibrozil. Background technique [0002] Glioma is the most common primary malignant intracranial tumor. It can be found in all age groups, mostly in adults, and there is no significant difference in incidence between men and women. It has the characteristics of high disability rate, high recurrence rate and high mortality rate. The treatment of glioma mainly adopts surgical resection, postoperative radiotherapy and chemotherapy, but the average postoperative survival period of patients with glioma grade III and IV (high grade) according to the WHO classification is not more than 1 year, even after surgery Treatment with radiotherapy and the current first-line chemotherapy drug Temozolomide (TMZ) can only prolong the average survival time by about half a year. Therefore, there is still a lack of effective methods for the treatment of high-grade gl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61K31/4188A61P35/00
CPCA61K31/192A61K31/4188A61P35/00A61K2300/00
Inventor 葛鹏飞孟繁开
Owner 葛鹏飞
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