Protein markers for Sjögren's syndrome in saliva and uses thereof

A technology for Sjögren's syndrome and protein, applied in biological tests, instruments, measuring devices, etc., can solve the problems of insufficient protein identification depth, lack of diagnostic accuracy and evaluation, etc.
CN110082540BActive Publication Date: 2020-08-04THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2020-08-04

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Abstract

The invention relates to a protein marker for sicca syndrome in saliva and application of the protein marker. Particularly, the invention relates to application of a protein identification reagent inpreparation of a reagent for diagnosing the sicca syndrome in a subject. Protin is selected from a combination of acylamino acid release enzyme, 1,4-glucose formyl transfer enzyme, Calumenin, C-C motif chemotatic factor ligand 28, activation-induced cytidine deaminase, alpha collagen 1 chain, carboxypeptidase D, carboxypeptidase E, cysteine proteinase inhibitor C, cathepsin L, DnaJ heat shock protein family (Hsp40) member C3, furan paired basic amino acid lyase, HtrA serine peptidase 1, kallikrein correlated peptidase 11, trypsin 3, proteasome subunit-4, proteasome subunit 9, antichymotrypsinand vimentin.
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Description

technical field

[0001] The invention relates to the field of biotechnology, more specifically to a protein marker of Sjögren's syndrome in saliva and its application in early diagnosis. Background technique

[0002] Sjögren's syndrome (SS) is a chronic autoimmune disease that mainly invades exocrine glands. It can be divided into primary and secondary types. Clinically, salivary gland and lacrimal gland involvement are the main clinical manifestations. Primary Sjogren's syndrome refers to Sjögren's syndrome without another diagnosed autoimmune disease. Secondary Sjögren's syndrome refers to Sjögren's syndrome combined with another autoimmune disease such as rheumatoid arthritis and systemic lupus erythematosus. The global prevalence of Sjögren's syndrome is between 0.5-2.0%, with 90% being female (see, e.g., S. Gonzalez, H. Sung, D. Sepulveda, M. Gonzalez, C. Molina, Oral manifestations and their treatment in Sjogren's syndrome, Oral diseases, 20(2014) 153-161). About 5%-...

Claims

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