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Tooth extraction socket repairing bracket having antibacterial activity and preparation method

A technology of antibacterial activity and antibacterial drugs, applied in the field of biomaterial preparation, can solve the problems of affecting blood supply, increasing operation difficulty and operation time, and easy secondary infection, so as to prevent tooth extraction socket infection, reduce operation difficulty and operation time, Facilitates a slow release effect

Active Publication Date: 2019-08-06
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the practice of the inventors of the present disclosure found that secondary infection is easy to occur in the tooth extraction socket and the complex environment of the oral cavity, resulting in failure of bone repair
At the same time, the conventional site preservation technique needs to cover the surface of the filling material with a barrier membrane and free the normal mucosa for suture fixation, which not only increases the difficulty and operation time of the operation, but also excessive tissue stripping will affect the local blood supply, which will further aggravate the bone resorption of alveolar ridge

Method used

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  • Tooth extraction socket repairing bracket having antibacterial activity and preparation method
  • Tooth extraction socket repairing bracket having antibacterial activity and preparation method
  • Tooth extraction socket repairing bracket having antibacterial activity and preparation method

Examples

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preparation example Construction

[0032] Another embodiment of the present disclosure provides a method for preparing the above-mentioned repair scaffold, comprising the following steps:

[0033] The first collagen solution is vacuum freeze-dried to obtain a collagen sponge, and the collagen sponge is squeezed to obtain a dense collagen film;

[0034] The collagen-hydroxyapatite suspension is prepared by using collagen, calcium hydroxide and phosphoric acid, the second collagen solution and the material containing the broad-spectrum antibacterial are added to the collagen-hydroxyapatite suspension, and the mixed solution is obtained after mixing evenly;

[0035] The mixture is injected into the mold, the mold is filled with the mixture, the mold mouth is covered with a dense collagen film, and vacuum freeze-drying is performed;

[0036] The mold is a tool that contains a pit in the shape of the extraction socket, such as figure 2 shown.

[0037] In one or more examples of this embodiment, the conditions for...

Embodiment 1

[0059] (1) Take 100 mL of an acid-extracted collagen solution with a mass concentration of 5 mg / mL, inject it into a 10 cm × 10 cm × 1 cm polytetrafluoroethylene mold, freeze at -20 ° C for 4 hours, and then perform vacuum freeze drying for 48 hours, and the vacuum degree is 100Pa , to obtain a collagen sponge.

[0060] (2) Put the collagen sponge on the stainless steel base of the press, apply a force of 300 kg, and maintain the pressure for 5 minutes to obtain a dense collagen film, which is used as the cone bottom of the repair material for the extraction socket.

[0061] (3) Measure 50 mL of silk fibroin solution with a mass concentration of 80 mg / mL, add minocycline hydrochloride to make its concentration 50 mg / mL, fully stir at 100 rpm for 60 min, and then place it in a 60°C water bath for heating Allow 60 hours to form a gel, then cool to room temperature and set aside.

[0062] (4) Take 100 mL of a collagen solution with a mass concentration of 5 mg / mL, weigh 0.36 g o...

Embodiment 2

[0065] (1) Take 100mL of acid-extracted collagen solution with a mass concentration of 10mg / mL, inject it into a 10cm×10cm×1cm polytetrafluoroethylene mold, freeze at -80°C for 4 hours, and then vacuum freeze-dry for 48 hours, with a vacuum degree of 150Pa , to obtain a collagen sponge.

[0066] (2) Put the collagen sponge on the stainless steel base of the press, apply a force of 500 kg, and maintain the pressure for 5 minutes to obtain a dense collagen film, which is used as the cone bottom of the dental socket repair bracket.

[0067] (3) measure the silk fibroin solution whose mass concentration is 60mg / mL, add minocycline hydrochloride, and make its concentration be

[0068] 10 mg / mL, fully stirred at 150 rpm for 120 min, then placed in a 45° C. water bath for heating for 24 hours to form a gel, and then cooled to room temperature for use.

[0069] (4) Take 100 mL of collagen solution with a mass concentration of 10%, weigh 2.2 g of calcium hydroxide, fully disperse it i...

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Abstract

The invention provides a tooth extraction socket repairing bracket having antibacterial activity and a preparation method. The repairing bracket adopts a conical structure which can be matched with atooth extraction socket; the conical structure is formed by solidification of repairing materials; a layer of collagen dense film is adhered to the conical bottom of the conical structure; the repairing material comprises a collagen-hydroxylapatite composite material, collagen, and minocycline hydrochloride, wherein the mass ratio of the collagen-hydroxylapatite composite material to the collagento broad spectrum antibiotic drugs is (1-6) to (0-6) to (0.1-1.5), and the collagen is not 0; and the collagen dense film is obtained through the steps of performing freeze drying on a collagen solution and performing extrusion. The repairing bracket disclosed by the invention can realize stuffing of the tooth extraction socket in one step, and can prevent infection.

Description

technical field [0001] The present disclosure belongs to the field of biological material preparation, and relates to a tooth extraction socket repair bracket with antibacterial activity and a preparation method. Background technique [0002] The statements herein merely provide background information related to the present disclosure and do not necessarily constitute prior art. [0003] Clinically, when the teeth cannot be retained due to periodontitis, dental caries, etc., the affected tooth needs to be extracted. After the affected tooth is extracted, an extraction socket is left. Organization and ossification leading to self-healing of the extraction socket. Because most of the extraction sockets have a chronic inflammatory process, the extraction wound is in direct contact with the oral cavity, and bad irritants such as saliva and bacteria in the mouth can easily enter the extraction socket and cause wound infection. At the same time, during the self-healing process of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/24A61L27/54A61L27/56
CPCA61L27/46A61L27/24A61L27/54A61L27/56A61L2300/406A61L2300/204A61L2300/602C08L89/00
Inventor 谈万业孙明霞于璐刘超汝璐彭化海吕志磊曹延文
Owner SHANDONG UNIV QILU HOSPITAL
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