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Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost

A nucleation and ice crystal technology, applied in the directions of drying gas arrangement, drying, drying machine, etc., can solve problems such as increasing the inhomogeneity between bottles of freeze-dried products

Pending Publication Date: 2019-08-09
MILLROCK TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As the shelves of the freeze dryer are continuously cooled, the time lag between the first vial freezing and the last vial freezing creates vial-to-vial temperature differences, which increases vial-to-vial inhomogeneity in the freeze-dried product

Method used

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  • Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost
  • Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost
  • Controlled nucleation during freezing step of freeze drying cycle using pressure differential ice crystals distribution from condensed frost

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Embodiment Construction

[0021] as in figure 1 As shown, the apparatus 10 for carrying out the method of the present invention comprises a lyophilizer 12 having one or more shelves 14 for supporting vials of product to be lyophilized. The condensation chamber 16 is connected to the lyophilizer 12 through a vapor port 18 having an isolation valve 20 of any suitable configuration between the condensation chamber 16 and the lyophilizer 12 . Preferably, the isolation valve 20 is constructed as a bi-directional sealed vacuum.

[0022] The vacuum pump 22 is connected to the condensing chamber 16 by a valve 21 between them and of any suitable configuration. Condensate chamber 16 has fill valve 24 and vent valve 27 and filter 28 with any suitable structure, and freeze dryer 12 has control valve 25 and release valve 26 with any suitable structure.

[0023] As an illustrative example, the operation of apparatus 10 according to one embodiment of the method of the present invention is as follows:

[0024] 1. ...

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Abstract

A method of controlling and enhancing the nucleation of product in a freeze dryer is provided, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freezedryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separated from the product chamber and connected thereto by a vapor port. The opening of thevapor port into the product chamber when the condenser chamber has a pressure that is greater than that of the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.

Description

[0001] Divisional Application Instructions [0002] This application is the application date of September 18, 2014, the application number is 201480076298.2, and the invention title is "Controlled nucleation of ice crystal distribution using differential pressure from condensate frost in the freezing process of freeze-drying cycle". Divisional application. [0003] CROSS-REFERENCE TO RELATED APPLICATIONS [0004] This application claims priority to US patent application Ser. No. 14 / 205,802, filed March 12, 2014, which is hereby incorporated by reference in its entirety. [0005] This application is a continuation-in-part of US Patent Application No. 13 / 572,978, filed on August 13, 2012, the entire contents of which are hereby incorporated by reference. technical field [0006] The present invention relates to a method for controlling nucleation in the freezing step of a freeze-drying cycle, and more particularly to a method for triggering spontaneous nucleation of all bot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F26B5/06F26B21/14
CPCF26B5/06
Inventor 凌伟佳
Owner MILLROCK TECH
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