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Jet flow power control for object sorting

An object, jet technology, used in fluid controllers, laboratory containers, analytical materials, etc., to solve problems such as preventing sorting, damaging cells or objects and heater elements

Pending Publication Date: 2019-08-09
INTERUNIVERSITAIR MICRO ELECTRONICS CENT (IMEC VZW) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Excessive power may damage cells or objects and heater elements, and may even prevent correct sorting

Method used

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  • Jet flow power control for object sorting
  • Jet flow power control for object sorting
  • Jet flow power control for object sorting

Examples

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Embodiment Construction

[0048] The present invention will be described with respect to particular embodiments and with reference to certain drawings but the invention is not limited thereto but only by the claims. The drawings described are only schematic and non-limiting. In the drawings, the size of some of the elements may be exaggerated and not drawn on scale for illustrative purposes. The dimensions and relative dimensions do not correspond to actual reductions for the practice of the invention.

[0049] Furthermore, the terms first, second etc. in the description and claims are used to distinguish between similar elements and not necessarily to describe a sequence in time, space, order or any other way. It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments of the invention described herein are capable of operation in sequences other than described or illustrated herein.

[0050] Furthermore, the terms top, below and similar ...

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PUM

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Abstract

A microfluidic actuator (100) for selecting objects in a fluid stream comprising a plurality of objects is described. The actuator (100) comprises an object detection means (101) adapted for, upon arrival of an object, identifying whether an object is an object of interest. It further comprises a heater (113) adapted for generating a jet flow for deflecting an object of interest from the fluid stream and a controller (104) for activating the heater (113) as function of the detection of an object of interest using a nucleation signal. The controller (104) is adapted for obtaining temperature information of the heater (113) and for adjusting a nucleation signal for the heater (113) taking into account the obtained temperature information.

Description

technical field [0001] The present invention relates to the field of microfluidic actuation. More specifically, it relates to a system and method for controlling the power supply of a microbubble jet generator. Background technique [0002] A microfluidic cell sorter is a device that sorts and classifies particles, such as cells, in a flow and sends them in different directions (eg, different channels or outlets) under predetermined factors or conditions. For example, the sorter may send particles with a predetermined fluorophore attached to them toward the sorting outlet upon detection of their fluorescence, and send other particles to a different channel. Cells flowing in a microfluidic chip can be sorted by applying force to them as they pass through a sorter, for example with precisely timed jets. After a cell of interest is detected (eg, as the cell passes through the detection zone) a short pulse is applied to the actuator. The resulting jet deflects passing cells t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01L7/00G01N15/10G01N15/14
CPCB01L3/502761B01L7/54B01L2200/0652B01L2200/147B01L2300/0864B01L2300/1827B01L2400/0442G01N2015/1006G01N15/147G01N15/149G01N15/10G01N2015/1028
Inventor K·J·H·G·德韦斯刘诚迅
Owner INTERUNIVERSITAIR MICRO ELECTRONICS CENT (IMEC VZW)