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Method for optimizing infant brain T1 weighted magnetic resonance imaging

A magnetic resonance imaging and infant technology, which is applied in magnetic resonance measurement, measurement using nuclear magnetic resonance imaging system, measurement of magnetic variables, etc., to achieve the effects of short acquisition time, high isotropic resolution, and easy implementation.

Active Publication Date: 2019-08-16
ZHEJIANG UNIV
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Problems solved by technology

However, in addition to developing advanced image processing algorithms, improving image contrast during acquisition will also benefit subsequent analysis.

Method used

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  • Method for optimizing infant brain T1 weighted magnetic resonance imaging
  • Method for optimizing infant brain T1 weighted magnetic resonance imaging
  • Method for optimizing infant brain T1 weighted magnetic resonance imaging

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Embodiment

[0092] The optimization method described above for T1-weighted MRI of the infant brain was tested. Firstly, a Philips 3T MRI scanner (Achieva; Philips Healthcare, Best, The Netherlands) was used to collect "MIX" sequence images of the brains of 57 normally developing infants, and the spin-echo (spin-echo, SE) was solved using the ratio and least square method and inversion recovery (IR) signal equations to obtain T1 and PD maps respectively, and to normalize brain PD values ​​with the PD value of the lateral ventricle as the standard.

[0093] Regions of interest (ROI) were drawn manually on T1maps, including cortical gray matter (GM) and subcortical white matter (WM), and the average T1 value of the subcortical white matter was calculated for each infant brain as the infant The average T1 value of brain white matter; calculate the average PD value of subcortical white matter as the average PD value of infant brain white matter; calculate the average T1 value of cerebral corte...

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Abstract

The invention discloses a method for optimizing infant brain T1 weighted magnetic resonance imaging. The method includes, firstly, collecting T1 and PD mapping of the brain of infants aged 0-12 monthsto obtain the average T1 and PD values of the infants' white matter and infants' gray matter, and dividing the infants into three-month-old groups according to the characteristics of the relationshipbetween the T1 value of infants' white matter and the T1 value of gray matter; then, calculating the theoretical signal intensities of infants' white matter and gray matter in 3D T1 weighted images through Bloch simulation, and respectively determining an optimal theoretical TI optimization scheme for each group according to the contrast characteristics of infants' white matter / gray matter underdifferent TI; and finally, applying the optimal theoretical TI optimization scheme to the target infant's brain for 3D T1 weighted magnetic resonance imaging. According to the method, the blank of brain T1 weighted imaging optimization in the whole infant period from 0 to 12 months after birth is filled, the infants are divided into three-month-old groups according to the characteristics of the relationship between the T1 values of infants' white matter and the T1 value of infants' gray matter, and the optimal TI optimization schemes of different-month-old groups are respectively found, so that the T1 weighted imaging contrast of the infants' brain is obviously improved.

Description

technical field [0001] This application relates to the field of brain magnetic resonance imaging optimization, in particular to the optimization of infant brain T1 weighted imaging. Background technique [0002] Magnetic resonance imaging (MRI) of the infant brain is a safe and versatile method for examining infant brain structure, function, and disease during early development. However, poor imaging contrast of the infant brain and rapid changes in image contrast due to rapid brain development in the first year of life make anatomical demarcation and automated image analysis of infant brain imaging difficult. Due to the prolonged T1 relaxation time due to the immature development of white matter (white matter, WM) myelin sheath at birth, white matter and gray matter (grey matter, GM) ) contrast to that of the adult brain. In older infants, contrast is similar to that of adults, and this inversion is preceded by a period of similar WM and GM signals, usually between 3 and ...

Claims

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Application Information

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IPC IPC(8): A61B5/055
CPCA61B5/055G01R33/5602G01R33/50A61B5/0042A61B5/4064
Inventor 吴丹张祎刘婷婷张洪锡
Owner ZHEJIANG UNIV
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