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Soapberry in-situ gel preparation for treating candida albicans vaginitis and preparing method thereof

A candida-resistant, in-situ gel technology, which is applied in the direction of antifungal agents, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problem of low purity of saponins, achieve simple preparation, reduce Relapse rate, the effect of prolonging the effective residence time of drugs

Inactive Publication Date: 2019-08-16
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the water extraction and alcohol precipitation method is the most common application, but the purity of the saponins is not high

Method used

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  • Soapberry in-situ gel preparation for treating candida albicans vaginitis and preparing method thereof
  • Soapberry in-situ gel preparation for treating candida albicans vaginitis and preparing method thereof
  • Soapberry in-situ gel preparation for treating candida albicans vaginitis and preparing method thereof

Examples

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preparation example Construction

[0042] Preparation of Sapindus water extraction and fermentation concentrate:

[0043] Grind the dried Sapindus fruit peel to 20-60 mesh, extract the powder and water at a mass ratio of 1:3 for 6 hours at 40°C, and filter to obtain the first filtrate and filter residue. Under the same temperature conditions, extract the filter residue with water at a ratio of 1:2 for 4 hours, filter to obtain the second filtrate, discard the filter residue, and combine the two filtrates to obtain the crude filtrate of Sapindus saponin. The crude filtrate was centrifuged at 6000r / min for 10min to obtain the aqueous extract of Sapindus chinensis, which was concentrated 6 times in an evaporation device to obtain the concentrated solution of Sapindus saponin. Wine dry yeast was selected as the fermentation strain, and it was fermented at 30°C for 4 days with 1.0% inoculum to obtain the concentrated liquid of Sapindus water extraction fermentation.

Embodiment 1

[0045]This implementation provides a preparation method of Sapindia in situ gel preparation for the treatment of Candida albicans vaginitis, wherein the Sapindia in situ gel preparation includes the following components by weight: 50 parts of Sapindia in situ Fermentation concentrate (20mg / mL is recorded as saponin), 20 parts of poloxamer 407, 3 parts of poloxamer 188, 2 parts of polyethylene glycol 400, distilled water to make up to 100 parts, Sapindus in situ gel The concentration of Sapindus saponin in the preparation is 10 mg / mL.

[0046] The preparation method of the Sapindus in situ gel preparation of the present embodiment is as follows:

[0047] At 4°C, weigh polyethylene glycol 400 in parts by weight and dissolve it in 50 parts of sapindus water-extracted fermentation concentrate, mix well, add poloxamer 407 and poloxamer 188 to swell completely, continue to add distilled water To 100 parts, after mixing, obtain Sapindus in situ gel preparation.

Embodiment 2

[0049] This implementation provides a method for preparing a Sapindia in situ gel preparation for the treatment of Candida albicans vaginitis, wherein the Sapindia in situ gel preparation includes the following components by weight: Sapindiae water extraction fermentation concentration 50 parts of solution (30 mg / mL is recorded as saponin), 20 parts of poloxamer 407, 3 parts of poloxamer 188, 2 parts of polyethylene glycol 400, distilled water to make up to 100 parts, Sapindus in situ gel The concentration of Sapindus saponin in the preparation is 15mg / mL.

[0050] The preparation method of the Sapindus in situ gel preparation of the present embodiment is as follows:

[0051] At 5°C, weigh polyethylene glycol 400 in parts by weight and dissolve it in 50 parts of sapindus water-extracted fermentation concentrate, mix well, add poloxamer 407 and poloxamer 188 to swell completely, continue to add distilled water To 100 parts, after mixing, obtain Sapindus in situ gel preparation...

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Abstract

The invention relates to a soapberry in-situ gel preparation for treating candida albicans vaginitis and a preparing method thereof, and belongs to the technical field of gynecological medication. Thepreparing method comprises the steps: preparing a water extraction fermentation concentrate of soapberry, preparing a water extract fermentation liquid with a proper concentration according to the saponin content, and preparing a temperature-sensitive gel from the water extract fermentation liquid, wherein the effective residence time in vagina is ensured. The soapberry in-situ gel preparation has the advantages of simple production, little toxic and side effects, and significant effect against candida albicans, and can avoid the potential drug resistance threat of azole antifungal agents, has wide soapberry sources and convenient material taking.

Description

technical field [0001] The invention relates to the technical field of gynecological medicines, in particular to a Sapindus in situ gel preparation for treating Candida albicans vaginitis and a preparation method thereof. Background technique [0002] Candida albicans is an opportunistic pathogen, and candidiasis is an infection caused by Candida species that may occur in the skin, eyes, oral cavity, esophagus, gastrointestinal tract, vagina, and vascular system. Vulvovaginal candidiasis (VVC) is a common female vaginal disease. According to statistics, worldwide, VVC is the most common fungal infection in humans, more than 75% of women have at least one attack in their lifetime, and 5%-8% of women will have repeated attacks. Vulvovaginitis candidiasis (VVC) is clinically manifested as itching, pain, and burning sensations in vaginal and vulvar tissues, and increased vaginal discharge, thereby affecting women's quality of life. [0003] Currently, azole antifungals, delive...

Claims

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Application Information

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IPC IPC(8): A61K36/77A61K9/06A61K47/10A61P15/02A61P31/10A61K131/00
CPCA61K9/0034A61K9/06A61K36/77A61K47/10A61K2236/19A61K2236/331A61K2236/39A61P15/02A61P31/10
Inventor 邱金丹李璐魏敏平于航谢云飞郭亚辉成玉梁姚卫蓉
Owner JIANGNAN UNIV
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