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Composition containing total gingerol and preparation method of composition

A composition, the technology of total gingerol, applied in the field of medicinal chemistry, achieves the effect of remarkable drug effect, cheap price and high quality

Active Publication Date: 2019-08-20
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no external preparation for rheumatic pain with gingerol as the active ingredient

Method used

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  • Composition containing total gingerol and preparation method of composition
  • Composition containing total gingerol and preparation method of composition
  • Composition containing total gingerol and preparation method of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the present invention takes ginger as the preparation of raw material total gingerol

[0022] (1) Extraction: Take ginger (15% of the total gingerol content in ginger) slices, add acetone to reflux for extraction for 1 hour, and extract 3 times in total, each time the mass-volume ratio of ginger to acetone is 1kg:4L, combine the extracts, and evaporate to dryness , get extract;

[0023] (2) Purification: Take the extract, load it on a normal phase silica gel column, the mass ratio of the extract to silica gel is 1:7, and use a mixture of petroleum ether / ethyl acetate to elute with a gradient of 1ml / min, the initial elution When the volume ratio of sherwood oil and ethyl acetate was 5:1, the elution was finished after 2h, and the volume ratio of sherwood oil and ethyl acetate was 1.5:1 when the elution was finished, and the eluate was collected and evaporated to dryness to obtain total ginger phenol. After testing: the sum of the contents of 6-gingerol, 8...

Embodiment 2

[0024] Embodiment 2: the present invention is the preparation of the total gingerol of raw material with dried ginger

[0025] (1) Extraction: Take dried ginger (the total gingerol content in dried ginger is 25%) and grind into powder, add ether and cold-soak for extraction for 96 hours, extract 4 times in total, each time the mass-volume ratio of dried ginger and ether is 1kg: 3L, combine and extract liquid, evaporated to dryness, to obtain extract;

[0026] (2) Purification: Take the extract, load it on a normal phase silica gel column, the mass ratio of the extract to silica gel is 1:15, and use the petroleum ether / ethyl acetate mixture to elute with a gradient of 1ml / min, and the initial elution When the volume ratio of sherwood oil and ethyl acetate was 4.5:1, the elution was finished after 2h, and the volume ratio of sherwood oil and ethyl acetate was 2:1 when the elution was finished, and the eluate was collected and evaporated to dryness to obtain total ginger phenol....

Embodiment 3

[0027] Embodiment 3: the present invention takes ginger oleoresin as the preparation of raw material total gingerol

[0028] (1) Extraction: Get ginger oleoresin (total gingerol content 30% in ginger oleoresin), add dichloromethane cold soaking to extract 60h, extract altogether 2 times, each time ginger oleoresin and dichloromethane volume ratio are 1L: 4L, combined extracts, evaporated to dryness, to obtain extract;

[0029] (2) Purification: Take the extract and load it on a normal-phase silica gel column. The mass ratio of the extract to silica gel is 1:10, and it is eluted with a mixture of petroleum ether / acetone at a rate of 1ml / min. The volume ratio of ether and acetone is 6:1, and the elution is finished after 2h. When the elution is finished, the volume ratio of sherwood oil and acetone is 1:1. The eluate is collected and evaporated to dryness to obtain total gingerols; The sum of the contents of 6-gingerol, 8-gingerol and 10-gingerol in gingerol is greater than 80%...

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Abstract

The invention relates to a composition having effect of relieving pain. According to the composition, total gingerol is used as an active component, pharmaceutically acceptable auxiliary materials orauxiliary components are added, and a preparation is prepared, wherein the total content of 6-gingerol, 8-gingerol and 10-gingerol in the total gingerol is greater than 50%. The composition having theeffect of relieving pain is good in transdermal absorption effects, notable in medicine effects, convenient to use, and free from stimulation to stomach and intestines. A preparation method of the active component namely the total gingerol is simple in operation steps, the used raw materials are low in price, the obtained total gingerol is high in quality, and the total gingerol is free from special smell of fresh ginger, and is suitable for being used as an active component of an external preparation.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to a composition containing total gingerol and a preparation method thereof. Background technique [0002] Rheumatoid arthritis (RA) is a chronic systemic disease with unknown etiology, mainly inflammatory synovitis. Its pathogenesis may be related to heredity, infection, sex hormones, etc. The pathology of RA arthritis mainly includes the proliferation of synovial lining cells, the infiltration of a large number of inflammatory cells in the interstitium, the neogenesis of microvessels, the formation of pannus, and the destruction of cartilage and bone tissue. Rheumatoid arthritis is a common acute or chronic inflammation of connective tissue. Commonly said rheumatoid arthritis is one of the main manifestations of rheumatic fever, clinically characterized by joint and muscle migratory soreness, redness and pain. It is related to group A beta-hemolytic streptococcal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P29/00A61P19/02A61P19/08A61P19/04A61P21/00
CPCA61K36/9068A61K9/0014A61K47/32A61P29/00A61P19/02A61P19/08A61P19/04A61P21/00A61K2236/33A61K2236/39A61K2236/55A61K2236/35A61K2236/333
Inventor 周先礼单连海黄帅
Owner SOUTHWEST JIAOTONG UNIV
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