Pyrone compounds and applications of compounds in resisting pseudomonas aeruginosa biofilm

A kind of technology of Pseudomonas aeruginosa and compound, which is applied in the application field of pyrone compounds and their anti-Pseudomonas aeruginosa biofilm

Active Publication Date: 2019-08-23
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, no drugs that can effectively inhibit the biofilm formation of Pseudomonas aeruginosa have been reported.

Method used

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  • Pyrone compounds and applications of compounds in resisting pseudomonas aeruginosa biofilm
  • Pyrone compounds and applications of compounds in resisting pseudomonas aeruginosa biofilm
  • Pyrone compounds and applications of compounds in resisting pseudomonas aeruginosa biofilm

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Experimental program
Comparison scheme
Effect test

Embodiment

[0026] This embodiment synthetic general formula is as the compound shown in formula II:

[0027]

[0028] in:

[0029] R=2,4-2NO 2 , 2,6-2Cl, 3,5-2CF 3 , 2,4-2Cl.

[0030] The synthesis method is:

[0031] A: In a 250mL three-necked flask, mix appropriate amounts of 1,3-cyclohexanedione, malononitrile and aromatic aldehydes with different substituents in a 1:1:1 mole ratio and heat until dissolved;

[0032] B: add a catalytic amount of 4-dimethylaminopyridine, and heat to reflux for 3-4 hours;

[0033] C: After cooling, a solid precipitates, and it is filtered with suction, and the solid is recrystallized with absolute ethanol to finally obtain a pure product.

[0034] Structure Identification:

[0035] The molecular weight, structure and purity of the series of new pyran compounds synthesized above were identified by nuclear magnetic resonance (NMR). The chemical structure identification results of nuclear magnetic resonance can be found in Figure 1-4 .

[0036] ...

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PUM

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Abstract

The invention relates to novel pyrone compounds and applications of the compounds in resisting a pseudomonas aeruginosa biofilm. The compounds have a structural formula represented by a formula I shown in the description, and in the formula, R=2,4-2NO2, 2,6-2Cl or 3,5-2CF3. The applications include an application of the compounds in preparation of a medicine resistant to the pseudomonas aeruginosabiofilm and an application of the compounds in preparation of a medicine resistant to pseudomonas aeruginosa infection.

Description

technical field [0001] The present invention relates to pyrone compound and its anti-pseudomonas aeruginosa biofilm application. Background technique [0002] Pseudomonas aeruginosa is widely distributed in human skin, digestive tract and respiratory tract, etc. When the body's resistance decreases, it can cause infection. It is a common pathogen of hospital infection, especially on the surface of artificial implants and urinary catheters. It can protect bacteria from the attack of the body's immune cells, which is an important reason why it is difficult to completely eliminate Pseudomonas aeruginosa clinically and bacterial drug resistance. In addition, since Pseudomonas aeruginosa belongs to Gram-negative bacteria, and the biofilm formation mechanism of common clinical Gram-positive bacteria such as Staphylococcus is quite different, drugs that can inhibit the biofilm of Gram-positive bacteria may not be effective for Pseudomonas aeruginosa. impact on the formation of mon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/74A01N43/16A01P1/00A61K31/352A61P31/04
CPCC07D311/74A01N43/16A61K31/352A61P31/04
Inventor 李明凯苏珊尹鹏硕李洲朋陈光辉王仪昆曲迪薛小燕
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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